Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension
The objective of this cross‐sectional study was to investigate risk markers indicating the presence of albuminuria in patients with hypertension in rural sub‐Saharan Africa (SSA). Urine albumin‐creatinine ratio, glycated hemoglobin (HbA1c), blood pressure, anthropometry, and other patient characteri...
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| Veröffentlicht in: | The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2016-01, Vol.18 (1), p.27-30 |
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| container_title | The journal of clinical hypertension (Greenwich, Conn.) |
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| creator | Rasmussen, Jon B. Nordin, Lovisa S. Thomsen, Jakúp A. Rossing, Peter Bygbjerg, Ib C. Christensen, Dirk L. |
| description | The objective of this cross‐sectional study was to investigate risk markers indicating the presence of albuminuria in patients with hypertension in rural sub‐Saharan Africa (SSA). Urine albumin‐creatinine ratio, glycated hemoglobin (HbA1c), blood pressure, anthropometry, and other patient characteristics including medications were assessed. We identified 160 patients with hypertension, of whom 68 (42.5%) were co‐diagnosed with diabetes mellitus (DM). Among the included participants, 57 (35.6%) had albuminuria (microalbuminuria [n=43] and macroalbuminuria [n=14]). A backward multivariate logistic regression model identified age (per 10‐year increment) (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.03–1.95), HbA1c >53 compared with |
| doi_str_mv | 10.1111/jch.12662 |
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Urine albumin‐creatinine ratio, glycated hemoglobin (HbA1c), blood pressure, anthropometry, and other patient characteristics including medications were assessed. We identified 160 patients with hypertension, of whom 68 (42.5%) were co‐diagnosed with diabetes mellitus (DM). Among the included participants, 57 (35.6%) had albuminuria (microalbuminuria [n=43] and macroalbuminuria [n=14]). A backward multivariate logistic regression model identified age (per 10‐year increment) (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.03–1.95), HbA1c >53 compared with <48 mmol/mol (OR, 3.81; 95% CI, 1.74–8.35), and treatment with dihydropyridine calcium channel blockers (OR, 2.59; 95% CI, 1.09–6.16) as the variables significantly associated with albuminuria. Only dysregulated DM and age were the conventional risk markers that seemed to suggest albuminuria among patients with hypertension in rural SSA.</description><identifier>ISSN: 1524-6175</identifier><identifier>ISSN: 1751-7176</identifier><identifier>EISSN: 1751-7176</identifier><identifier>DOI: 10.1111/jch.12662</identifier><identifier>PMID: 26307089</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Aged ; Albuminuria - blood ; Albuminuria - diagnosis ; Albuminuria - physiopathology ; Albuminuria - urine ; Biomarkers - blood ; Biomarkers - urine ; Blood Pressure - physiology ; Cross-Sectional Studies ; Female ; Glycated Hemoglobin - analysis ; Humans ; Hypertension - blood ; Hypertension - physiopathology ; Hypertension - urine ; Male ; Middle Aged ; Original Paper ; Risk ; Rural Population ; Zambia</subject><ispartof>The journal of clinical hypertension (Greenwich, Conn.), 2016-01, Vol.18 (1), p.27-30</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4852-f1076823331d609b114d7cd6a7068aa1fdddae3b0d0d0f8ee753c470cde350903</citedby><cites>FETCH-LOGICAL-c4852-f1076823331d609b114d7cd6a7068aa1fdddae3b0d0d0f8ee753c470cde350903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031992/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031992/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,1432,27915,27916,45565,45566,46400,46824,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26307089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasmussen, Jon B.</creatorcontrib><creatorcontrib>Nordin, Lovisa S.</creatorcontrib><creatorcontrib>Thomsen, Jakúp A.</creatorcontrib><creatorcontrib>Rossing, Peter</creatorcontrib><creatorcontrib>Bygbjerg, Ib C.</creatorcontrib><creatorcontrib>Christensen, Dirk L.</creatorcontrib><title>Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension</title><title>The journal of clinical hypertension (Greenwich, Conn.)</title><addtitle>J Clin Hypertens (Greenwich)</addtitle><description>The objective of this cross‐sectional study was to investigate risk markers indicating the presence of albuminuria in patients with hypertension in rural sub‐Saharan Africa (SSA). Urine albumin‐creatinine ratio, glycated hemoglobin (HbA1c), blood pressure, anthropometry, and other patient characteristics including medications were assessed. We identified 160 patients with hypertension, of whom 68 (42.5%) were co‐diagnosed with diabetes mellitus (DM). Among the included participants, 57 (35.6%) had albuminuria (microalbuminuria [n=43] and macroalbuminuria [n=14]). A backward multivariate logistic regression model identified age (per 10‐year increment) (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.03–1.95), HbA1c >53 compared with <48 mmol/mol (OR, 3.81; 95% CI, 1.74–8.35), and treatment with dihydropyridine calcium channel blockers (OR, 2.59; 95% CI, 1.09–6.16) as the variables significantly associated with albuminuria. Only dysregulated DM and age were the conventional risk markers that seemed to suggest albuminuria among patients with hypertension in rural SSA.</description><subject>Aged</subject><subject>Albuminuria - blood</subject><subject>Albuminuria - diagnosis</subject><subject>Albuminuria - physiopathology</subject><subject>Albuminuria - urine</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Blood Pressure - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Glycated Hemoglobin - analysis</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Risk</subject><subject>Rural Population</subject><subject>Zambia</subject><issn>1524-6175</issn><issn>1751-7176</issn><issn>1751-7176</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EoqWw4AWQl7BIa8eJnWyQohEwoCJQC-rS8tg3M-4k9mAng-btuWVKBQvshf8-nXt9DiEvOTvnOC5u7eacl1KWj8gpVzUvFFfyMe7rsiok3pyQZznfMlYL0bKn5KSUginWtKdkuoY9JDPQRQx7CJOPAQ9XPm_pZ5O2kDK9ntdryJMPa_o1QYZggcaedsNqHn2Ykze0S0BvwGxpN0bEruY7xa5P3pqQ6Y2fNnR52EGaIGSs8Jw86c2Q4cX9eka-v3_3bbEsLr98-LjoLgtbNXVZ9Jwp2ZRCCO4ka1ecV05ZJ41isjGG9845A2LFHM6-AVC1sJVi1oGoWcvEGXl71N3NqxGcxf9hY3qX_GjSQUfj9b8vwW_0Ou51wwRv2xIFXt8LpPhjRhP06LOFYTAB4pw1Wluhx6KuEH1zRG2KOSfoH8pwpu9S0piS_p0Ssq_-7uuB_BMLAhdH4Kcf4PB_Jf1psTxK_gLfiZ48</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Rasmussen, Jon B.</creator><creator>Nordin, Lovisa S.</creator><creator>Thomsen, Jakúp A.</creator><creator>Rossing, Peter</creator><creator>Bygbjerg, Ib C.</creator><creator>Christensen, Dirk L.</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201601</creationdate><title>Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension</title><author>Rasmussen, Jon B. ; Nordin, Lovisa S. ; Thomsen, Jakúp A. ; Rossing, Peter ; Bygbjerg, Ib C. ; Christensen, Dirk L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4852-f1076823331d609b114d7cd6a7068aa1fdddae3b0d0d0f8ee753c470cde350903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Albuminuria - blood</topic><topic>Albuminuria - diagnosis</topic><topic>Albuminuria - physiopathology</topic><topic>Albuminuria - urine</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Blood Pressure - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Glycated Hemoglobin - analysis</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - urine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Risk</topic><topic>Rural Population</topic><topic>Zambia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasmussen, Jon B.</creatorcontrib><creatorcontrib>Nordin, Lovisa S.</creatorcontrib><creatorcontrib>Thomsen, Jakúp A.</creatorcontrib><creatorcontrib>Rossing, Peter</creatorcontrib><creatorcontrib>Bygbjerg, Ib C.</creatorcontrib><creatorcontrib>Christensen, Dirk L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasmussen, Jon B.</au><au>Nordin, Lovisa S.</au><au>Thomsen, Jakúp A.</au><au>Rossing, Peter</au><au>Bygbjerg, Ib C.</au><au>Christensen, Dirk L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension</atitle><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle><addtitle>J Clin Hypertens (Greenwich)</addtitle><date>2016-01</date><risdate>2016</risdate><volume>18</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>1524-6175</issn><issn>1751-7176</issn><eissn>1751-7176</eissn><abstract>The objective of this cross‐sectional study was to investigate risk markers indicating the presence of albuminuria in patients with hypertension in rural sub‐Saharan Africa (SSA). Urine albumin‐creatinine ratio, glycated hemoglobin (HbA1c), blood pressure, anthropometry, and other patient characteristics including medications were assessed. We identified 160 patients with hypertension, of whom 68 (42.5%) were co‐diagnosed with diabetes mellitus (DM). Among the included participants, 57 (35.6%) had albuminuria (microalbuminuria [n=43] and macroalbuminuria [n=14]). A backward multivariate logistic regression model identified age (per 10‐year increment) (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.03–1.95), HbA1c >53 compared with <48 mmol/mol (OR, 3.81; 95% CI, 1.74–8.35), and treatment with dihydropyridine calcium channel blockers (OR, 2.59; 95% CI, 1.09–6.16) as the variables significantly associated with albuminuria. Only dysregulated DM and age were the conventional risk markers that seemed to suggest albuminuria among patients with hypertension in rural SSA.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>26307089</pmid><doi>10.1111/jch.12662</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Albuminuria - blood Albuminuria - diagnosis Albuminuria - physiopathology Albuminuria - urine Biomarkers - blood Biomarkers - urine Blood Pressure - physiology Cross-Sectional Studies Female Glycated Hemoglobin - analysis Humans Hypertension - blood Hypertension - physiopathology Hypertension - urine Male Middle Aged Original Paper Risk Rural Population Zambia |
| title | Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension |
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