Higher arterial stiffness is associated with lower cognitive performance in patients with hypertension
Cognitive impairment and elevated arterial stiffness have been described in patients with arterial hypertension, but their association has not been well studied. We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with...
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| Veröffentlicht in: | The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2018-01, Vol.20 (1), p.22-30 |
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| creator | Muela, Henrique C.S. Costa‐Hong, Valeria A. Yassuda, Mônica S. Moraes, Natália C. Memória, Claudia M. Machado, Michel F. Bor‐Seng‐Shu, Edson Nogueira, Ricardo C. Mansur, Alfredo J. Massaro, Ayrton R. Nitrini, Ricardo Macedo, Thiago A. Bortolotto, Luiz A. |
| description | Cognitive impairment and elevated arterial stiffness have been described in patients with arterial hypertension, but their association has not been well studied. We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with normotension. We evaluated 211 patients (69 with normotension and 142 with hypertension). Patients were age matched and distributed according to their blood pressure: normotension, hypertension stage 1, and hypertension stage 2. Cognitive function was assessed using the Mini‐Mental State Examination, Montreal Cognitive Assessment, and a battery of neuropsychological evaluations that assessed six main cognitive domains. Pulse wave velocity was measured using a Complior device, and carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. The hypertension stage 2 group had higher arterial stiffness and worse performance either by Mini‐Mental State Examination (26.8±2.1 vs 27.3±2.1 vs 28.0±2.0, P=.003) or the Montreal Cognitive Assessment test (23.4±3.5 vs 24.9±2.9 vs 25.6±3.0, P |
| doi_str_mv | 10.1111/jch.13129 |
| format | Article |
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We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with normotension. We evaluated 211 patients (69 with normotension and 142 with hypertension). Patients were age matched and distributed according to their blood pressure: normotension, hypertension stage 1, and hypertension stage 2. Cognitive function was assessed using the Mini‐Mental State Examination, Montreal Cognitive Assessment, and a battery of neuropsychological evaluations that assessed six main cognitive domains. Pulse wave velocity was measured using a Complior device, and carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. The hypertension stage 2 group had higher arterial stiffness and worse performance either by Mini‐Mental State Examination (26.8±2.1 vs 27.3±2.1 vs 28.0±2.0, P=.003) or the Montreal Cognitive Assessment test (23.4±3.5 vs 24.9±2.9 vs 25.6±3.0, P<.001). On multivariable regression analysis, augmentation index, intima‐media thickness, and pulse wave velocity were the variables mainly associated with lower cognitive performance at different cognitive domains. Cognitive impairment in different domains was associated with higher arterial stiffness.</description><identifier>ISSN: 1524-6175</identifier><identifier>EISSN: 1751-7176</identifier><identifier>DOI: 10.1111/jch.13129</identifier><identifier>PMID: 29106057</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adult ; Arterial Stiffness ; Blood Pressure Determination - methods ; Brazil ; Cognition - physiology ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; cognitive impairment ; Correlation of Data ; Cross-Sectional Studies ; Female ; Humans ; hypertension ; Hypertension - complications ; Hypertension - diagnosis ; Hypertension - psychology ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Neuropsychological Tests ; Original Paper ; Pulse Wave Analysis ; pulse wave velocity ; Vascular Stiffness</subject><ispartof>The journal of clinical hypertension (Greenwich, Conn.), 2018-01, Vol.20 (1), p.22-30</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4159-704ed5a9e97f91edb72c6c982361464c76d39c7ae36d8b14472e3cde076241b63</citedby><cites>FETCH-LOGICAL-c4159-704ed5a9e97f91edb72c6c982361464c76d39c7ae36d8b14472e3cde076241b63</cites><orcidid>0000-0002-0071-9555</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031309/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031309/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29106057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muela, Henrique C.S.</creatorcontrib><creatorcontrib>Costa‐Hong, Valeria A.</creatorcontrib><creatorcontrib>Yassuda, Mônica S.</creatorcontrib><creatorcontrib>Moraes, Natália C.</creatorcontrib><creatorcontrib>Memória, Claudia M.</creatorcontrib><creatorcontrib>Machado, Michel F.</creatorcontrib><creatorcontrib>Bor‐Seng‐Shu, Edson</creatorcontrib><creatorcontrib>Nogueira, Ricardo C.</creatorcontrib><creatorcontrib>Mansur, Alfredo J.</creatorcontrib><creatorcontrib>Massaro, Ayrton R.</creatorcontrib><creatorcontrib>Nitrini, Ricardo</creatorcontrib><creatorcontrib>Macedo, Thiago A.</creatorcontrib><creatorcontrib>Bortolotto, Luiz A.</creatorcontrib><title>Higher arterial stiffness is associated with lower cognitive performance in patients with hypertension</title><title>The journal of clinical hypertension (Greenwich, Conn.)</title><addtitle>J Clin Hypertens (Greenwich)</addtitle><description>Cognitive impairment and elevated arterial stiffness have been described in patients with arterial hypertension, but their association has not been well studied. We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with normotension. We evaluated 211 patients (69 with normotension and 142 with hypertension). Patients were age matched and distributed according to their blood pressure: normotension, hypertension stage 1, and hypertension stage 2. Cognitive function was assessed using the Mini‐Mental State Examination, Montreal Cognitive Assessment, and a battery of neuropsychological evaluations that assessed six main cognitive domains. Pulse wave velocity was measured using a Complior device, and carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. The hypertension stage 2 group had higher arterial stiffness and worse performance either by Mini‐Mental State Examination (26.8±2.1 vs 27.3±2.1 vs 28.0±2.0, P=.003) or the Montreal Cognitive Assessment test (23.4±3.5 vs 24.9±2.9 vs 25.6±3.0, P<.001). On multivariable regression analysis, augmentation index, intima‐media thickness, and pulse wave velocity were the variables mainly associated with lower cognitive performance at different cognitive domains. Cognitive impairment in different domains was associated with higher arterial stiffness.</description><subject>Adult</subject><subject>Arterial Stiffness</subject><subject>Blood Pressure Determination - methods</subject><subject>Brazil</subject><subject>Cognition - physiology</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>cognitive impairment</subject><subject>Correlation of Data</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - psychology</subject><subject>Male</subject><subject>Mental Status and Dementia Tests</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Original Paper</subject><subject>Pulse Wave Analysis</subject><subject>pulse wave velocity</subject><subject>Vascular Stiffness</subject><issn>1524-6175</issn><issn>1751-7176</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vEzEQhi1ERT_gwB9APsJhW8_aa8cXJBTRhqoSFzhbjnc262pjB9tplH-P2y0VHJiLR55Hz4z0EvIe2CXUurp34yVwaPUrcgaqg0aBkq9r37WikfXnlJznfM9Yx7lmb8hpq4FJ1qkzMqz8ZsREbSqYvJ1oLn4YAuZMfaY25-i8LdjTgy8jneKhsi5ugi_-AekO0xDT1gaH1Ae6s8VjKHmGx2MdFwzZx_CWnAx2yvju-b0gP6-__liumrvvN9-WX-4aJ6DTjWIC-85q1GrQgP1atU46vWi5BCGFU7Ln2imLXPaLNQihWuSuR6ZkK2At-QX5PHt3-_UWe1evSXYyu-S3Nh1NtN78Owl-NJv4YBaMA2e6Cj4-C1L8tcdczNZnh9NkA8Z9NqAlMK64eEQ_zahLMeeEw8saYOYxF1NzMU-5VPbD33e9kH-CqMDVDBz8hMf_m8ztcjUrfwP2xZok</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Muela, Henrique C.S.</creator><creator>Costa‐Hong, Valeria A.</creator><creator>Yassuda, Mônica S.</creator><creator>Moraes, Natália C.</creator><creator>Memória, Claudia M.</creator><creator>Machado, Michel F.</creator><creator>Bor‐Seng‐Shu, Edson</creator><creator>Nogueira, Ricardo C.</creator><creator>Mansur, Alfredo J.</creator><creator>Massaro, Ayrton R.</creator><creator>Nitrini, Ricardo</creator><creator>Macedo, Thiago A.</creator><creator>Bortolotto, Luiz A.</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0071-9555</orcidid></search><sort><creationdate>201801</creationdate><title>Higher arterial stiffness is associated with lower cognitive performance in patients with hypertension</title><author>Muela, Henrique C.S. ; Costa‐Hong, Valeria A. ; Yassuda, Mônica S. ; Moraes, Natália C. ; Memória, Claudia M. ; Machado, Michel F. ; Bor‐Seng‐Shu, Edson ; Nogueira, Ricardo C. ; Mansur, Alfredo J. ; Massaro, Ayrton R. ; Nitrini, Ricardo ; Macedo, Thiago A. ; Bortolotto, Luiz A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4159-704ed5a9e97f91edb72c6c982361464c76d39c7ae36d8b14472e3cde076241b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Arterial Stiffness</topic><topic>Blood Pressure Determination - methods</topic><topic>Brazil</topic><topic>Cognition - physiology</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>cognitive impairment</topic><topic>Correlation of Data</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - psychology</topic><topic>Male</topic><topic>Mental Status and Dementia Tests</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Original Paper</topic><topic>Pulse Wave Analysis</topic><topic>pulse wave velocity</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muela, Henrique C.S.</creatorcontrib><creatorcontrib>Costa‐Hong, Valeria A.</creatorcontrib><creatorcontrib>Yassuda, Mônica S.</creatorcontrib><creatorcontrib>Moraes, Natália C.</creatorcontrib><creatorcontrib>Memória, Claudia M.</creatorcontrib><creatorcontrib>Machado, Michel F.</creatorcontrib><creatorcontrib>Bor‐Seng‐Shu, Edson</creatorcontrib><creatorcontrib>Nogueira, Ricardo C.</creatorcontrib><creatorcontrib>Mansur, Alfredo J.</creatorcontrib><creatorcontrib>Massaro, Ayrton R.</creatorcontrib><creatorcontrib>Nitrini, Ricardo</creatorcontrib><creatorcontrib>Macedo, Thiago A.</creatorcontrib><creatorcontrib>Bortolotto, Luiz A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muela, Henrique C.S.</au><au>Costa‐Hong, Valeria A.</au><au>Yassuda, Mônica S.</au><au>Moraes, Natália C.</au><au>Memória, Claudia M.</au><au>Machado, Michel F.</au><au>Bor‐Seng‐Shu, Edson</au><au>Nogueira, Ricardo C.</au><au>Mansur, Alfredo J.</au><au>Massaro, Ayrton R.</au><au>Nitrini, Ricardo</au><au>Macedo, Thiago A.</au><au>Bortolotto, Luiz A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher arterial stiffness is associated with lower cognitive performance in patients with hypertension</atitle><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle><addtitle>J Clin Hypertens (Greenwich)</addtitle><date>2018-01</date><risdate>2018</risdate><volume>20</volume><issue>1</issue><spage>22</spage><epage>30</epage><pages>22-30</pages><issn>1524-6175</issn><eissn>1751-7176</eissn><abstract>Cognitive impairment and elevated arterial stiffness have been described in patients with arterial hypertension, but their association has not been well studied. We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with normotension. We evaluated 211 patients (69 with normotension and 142 with hypertension). Patients were age matched and distributed according to their blood pressure: normotension, hypertension stage 1, and hypertension stage 2. Cognitive function was assessed using the Mini‐Mental State Examination, Montreal Cognitive Assessment, and a battery of neuropsychological evaluations that assessed six main cognitive domains. Pulse wave velocity was measured using a Complior device, and carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. The hypertension stage 2 group had higher arterial stiffness and worse performance either by Mini‐Mental State Examination (26.8±2.1 vs 27.3±2.1 vs 28.0±2.0, P=.003) or the Montreal Cognitive Assessment test (23.4±3.5 vs 24.9±2.9 vs 25.6±3.0, P<.001). On multivariable regression analysis, augmentation index, intima‐media thickness, and pulse wave velocity were the variables mainly associated with lower cognitive performance at different cognitive domains. Cognitive impairment in different domains was associated with higher arterial stiffness.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>29106057</pmid><doi>10.1111/jch.13129</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0071-9555</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE; Wiley Online Library Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Adult Arterial Stiffness Blood Pressure Determination - methods Brazil Cognition - physiology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology cognitive impairment Correlation of Data Cross-Sectional Studies Female Humans hypertension Hypertension - complications Hypertension - diagnosis Hypertension - psychology Male Mental Status and Dementia Tests Middle Aged Neuropsychological Tests Original Paper Pulse Wave Analysis pulse wave velocity Vascular Stiffness |
| title | Higher arterial stiffness is associated with lower cognitive performance in patients with hypertension |
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