Prehypertension is a comorbid state with autonomic and metabolic dysfunction
We aimed to elucidate the role of autonomic dysfunction in the context of complex metabolic and cardiovascular changes in subjects with prehypertension. We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR...
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| Veröffentlicht in: | The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2018-02, Vol.20 (2), p.273-279 |
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| container_title | The journal of clinical hypertension (Greenwich, Conn.) |
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| creator | Jung, Mi‐Hyang Ihm, Sang‐Hyun Lee, Dong‐Hyeon Choi, Young Chung, Woo‐Baek Jung, Hae Ok Hong, Kyung‐Soon Youn, Ho‐Joong |
| description | We aimed to elucidate the role of autonomic dysfunction in the context of complex metabolic and cardiovascular changes in subjects with prehypertension. We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR) after peak exercise to quantitatively measure autonomic dysfunction. Of the 556 participants, 279 individuals had prehypertension and the remaining 277 had optimal BP. HRR was significantly lower in the prehypertension group (36.0 ± 14.5 bpm) than in the optimal BP group (39.3 ± 14.7 bpm, P = .009). The prehypertension group more frequently demonstrated features of metabolic disturbances and subclinical target organ damage. Among the various baseline cardiovascular and metabolic factors assessed, resting systolic BP and high‐density lipoprotein cholesterol level were independent determinants of HRR (both P |
| doi_str_mv | 10.1111/jch.13180 |
| format | Article |
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We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR) after peak exercise to quantitatively measure autonomic dysfunction. Of the 556 participants, 279 individuals had prehypertension and the remaining 277 had optimal BP. HRR was significantly lower in the prehypertension group (36.0 ± 14.5 bpm) than in the optimal BP group (39.3 ± 14.7 bpm, P = .009). The prehypertension group more frequently demonstrated features of metabolic disturbances and subclinical target organ damage. Among the various baseline cardiovascular and metabolic factors assessed, resting systolic BP and high‐density lipoprotein cholesterol level were independent determinants of HRR (both P < .05). Autonomic dysfunction coexists with prehypertension and is closely linked to changes in systolic BP and lipid metabolism.</description><identifier>ISSN: 1524-6175</identifier><identifier>EISSN: 1751-7176</identifier><identifier>DOI: 10.1111/jch.13180</identifier><identifier>PMID: 29316211</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>autonomic nervous system ; Autonomic Nervous System Diseases - complications ; Autonomic Nervous System Diseases - diagnosis ; Autonomic Nervous System Diseases - physiopathology ; Blood Pressure - physiology ; Cardiovascular Effects of Hypertension ; Cardiovascular System - physiopathology ; Cholesterol, HDL - blood ; Correlation of Data ; Cross-Sectional Studies ; exercise test ; Exercise Test - methods ; Female ; heart rate ; Heart Rate - physiology ; Humans ; Male ; Metabolic Diseases - complications ; Metabolic Diseases - diagnosis ; Metabolic Diseases - physiopathology ; metabolic syndrome ; Middle Aged ; Original Paper ; prehypertension ; Prehypertension - complications ; Prehypertension - diagnosis ; Prehypertension - metabolism ; Prehypertension - physiopathology ; Republic of Korea - epidemiology</subject><ispartof>The journal of clinical hypertension (Greenwich, Conn.), 2018-02, Vol.20 (2), p.273-279</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4150-b9f8bdac8acf0be3d7518c199ffc3efa990c97b5b0ec07a8d43e2d45df0d81213</citedby><cites>FETCH-LOGICAL-c4150-b9f8bdac8acf0be3d7518c199ffc3efa990c97b5b0ec07a8d43e2d45df0d81213</cites><orcidid>0000-0003-0224-5178 ; 0000-0001-5017-5421</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030957/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030957/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29316211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Mi‐Hyang</creatorcontrib><creatorcontrib>Ihm, Sang‐Hyun</creatorcontrib><creatorcontrib>Lee, Dong‐Hyeon</creatorcontrib><creatorcontrib>Choi, Young</creatorcontrib><creatorcontrib>Chung, Woo‐Baek</creatorcontrib><creatorcontrib>Jung, Hae Ok</creatorcontrib><creatorcontrib>Hong, Kyung‐Soon</creatorcontrib><creatorcontrib>Youn, Ho‐Joong</creatorcontrib><title>Prehypertension is a comorbid state with autonomic and metabolic dysfunction</title><title>The journal of clinical hypertension (Greenwich, Conn.)</title><addtitle>J Clin Hypertens (Greenwich)</addtitle><description>We aimed to elucidate the role of autonomic dysfunction in the context of complex metabolic and cardiovascular changes in subjects with prehypertension. We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR) after peak exercise to quantitatively measure autonomic dysfunction. Of the 556 participants, 279 individuals had prehypertension and the remaining 277 had optimal BP. HRR was significantly lower in the prehypertension group (36.0 ± 14.5 bpm) than in the optimal BP group (39.3 ± 14.7 bpm, P = .009). The prehypertension group more frequently demonstrated features of metabolic disturbances and subclinical target organ damage. Among the various baseline cardiovascular and metabolic factors assessed, resting systolic BP and high‐density lipoprotein cholesterol level were independent determinants of HRR (both P < .05). Autonomic dysfunction coexists with prehypertension and is closely linked to changes in systolic BP and lipid metabolism.</description><subject>autonomic nervous system</subject><subject>Autonomic Nervous System Diseases - complications</subject><subject>Autonomic Nervous System Diseases - diagnosis</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular Effects of Hypertension</subject><subject>Cardiovascular System - physiopathology</subject><subject>Cholesterol, HDL - blood</subject><subject>Correlation of Data</subject><subject>Cross-Sectional Studies</subject><subject>exercise test</subject><subject>Exercise Test - methods</subject><subject>Female</subject><subject>heart rate</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Diseases - complications</subject><subject>Metabolic Diseases - diagnosis</subject><subject>Metabolic Diseases - physiopathology</subject><subject>metabolic syndrome</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>prehypertension</subject><subject>Prehypertension - complications</subject><subject>Prehypertension - diagnosis</subject><subject>Prehypertension - metabolism</subject><subject>Prehypertension - physiopathology</subject><subject>Republic of Korea - epidemiology</subject><issn>1524-6175</issn><issn>1751-7176</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFPwyAUx4nR6Jwe_AKmRz1UobQrXEzMok6zRA96JhQeDtOWCdRl3150avQgF-Dx4_de_ggdEXxG0jp_UYszQgnDW2hE6orkNakn2-lcFWU-SZU9tB_CC8YVpRzvor2CUzIpCBmh-YOHxXoJPkIfrOszGzKZKdc531idhSgjZCsbF5kcoutdZ1Ume511EGXj2nTT62CGXsX0-QDtGNkGOPzax-jp-upxOsvn9ze308t5rkpS4bzhhjVaKiaVwQ1QnUZminBujKJgJOdY8bqpGgwK15LpkkKhy0obrBkpCB2ji413OTQdaAV99LIVS2876dfCSSv-vvR2IZ7dm2CYYl7VSXDyJfDudYAQRWeDgraVPbghCMIZrxgteZHQ0w2qvAvBg_lpQ7D4SF-k9MVn-ok9_j3XD_kddwLON8DKtrD-3yTuprON8h1iF5GD</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Jung, Mi‐Hyang</creator><creator>Ihm, Sang‐Hyun</creator><creator>Lee, Dong‐Hyeon</creator><creator>Choi, Young</creator><creator>Chung, Woo‐Baek</creator><creator>Jung, Hae Ok</creator><creator>Hong, Kyung‐Soon</creator><creator>Youn, Ho‐Joong</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0224-5178</orcidid><orcidid>https://orcid.org/0000-0001-5017-5421</orcidid></search><sort><creationdate>201802</creationdate><title>Prehypertension is a comorbid state with autonomic and metabolic dysfunction</title><author>Jung, Mi‐Hyang ; Ihm, Sang‐Hyun ; Lee, Dong‐Hyeon ; Choi, Young ; Chung, Woo‐Baek ; Jung, Hae Ok ; Hong, Kyung‐Soon ; Youn, Ho‐Joong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4150-b9f8bdac8acf0be3d7518c199ffc3efa990c97b5b0ec07a8d43e2d45df0d81213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>autonomic nervous system</topic><topic>Autonomic Nervous System Diseases - complications</topic><topic>Autonomic Nervous System Diseases - diagnosis</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Blood Pressure - physiology</topic><topic>Cardiovascular Effects of Hypertension</topic><topic>Cardiovascular System - physiopathology</topic><topic>Cholesterol, HDL - blood</topic><topic>Correlation of Data</topic><topic>Cross-Sectional Studies</topic><topic>exercise test</topic><topic>Exercise Test - methods</topic><topic>Female</topic><topic>heart rate</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Diseases - complications</topic><topic>Metabolic Diseases - diagnosis</topic><topic>Metabolic Diseases - physiopathology</topic><topic>metabolic syndrome</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>prehypertension</topic><topic>Prehypertension - complications</topic><topic>Prehypertension - diagnosis</topic><topic>Prehypertension - metabolism</topic><topic>Prehypertension - physiopathology</topic><topic>Republic of Korea - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Mi‐Hyang</creatorcontrib><creatorcontrib>Ihm, Sang‐Hyun</creatorcontrib><creatorcontrib>Lee, Dong‐Hyeon</creatorcontrib><creatorcontrib>Choi, Young</creatorcontrib><creatorcontrib>Chung, Woo‐Baek</creatorcontrib><creatorcontrib>Jung, Hae Ok</creatorcontrib><creatorcontrib>Hong, Kyung‐Soon</creatorcontrib><creatorcontrib>Youn, Ho‐Joong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Mi‐Hyang</au><au>Ihm, Sang‐Hyun</au><au>Lee, Dong‐Hyeon</au><au>Choi, Young</au><au>Chung, Woo‐Baek</au><au>Jung, Hae Ok</au><au>Hong, Kyung‐Soon</au><au>Youn, Ho‐Joong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prehypertension is a comorbid state with autonomic and metabolic dysfunction</atitle><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle><addtitle>J Clin Hypertens (Greenwich)</addtitle><date>2018-02</date><risdate>2018</risdate><volume>20</volume><issue>2</issue><spage>273</spage><epage>279</epage><pages>273-279</pages><issn>1524-6175</issn><eissn>1751-7176</eissn><abstract>We aimed to elucidate the role of autonomic dysfunction in the context of complex metabolic and cardiovascular changes in subjects with prehypertension. We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR) after peak exercise to quantitatively measure autonomic dysfunction. Of the 556 participants, 279 individuals had prehypertension and the remaining 277 had optimal BP. HRR was significantly lower in the prehypertension group (36.0 ± 14.5 bpm) than in the optimal BP group (39.3 ± 14.7 bpm, P = .009). The prehypertension group more frequently demonstrated features of metabolic disturbances and subclinical target organ damage. Among the various baseline cardiovascular and metabolic factors assessed, resting systolic BP and high‐density lipoprotein cholesterol level were independent determinants of HRR (both P < .05). Autonomic dysfunction coexists with prehypertension and is closely linked to changes in systolic BP and lipid metabolism.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>29316211</pmid><doi>10.1111/jch.13180</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0224-5178</orcidid><orcidid>https://orcid.org/0000-0001-5017-5421</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | autonomic nervous system Autonomic Nervous System Diseases - complications Autonomic Nervous System Diseases - diagnosis Autonomic Nervous System Diseases - physiopathology Blood Pressure - physiology Cardiovascular Effects of Hypertension Cardiovascular System - physiopathology Cholesterol, HDL - blood Correlation of Data Cross-Sectional Studies exercise test Exercise Test - methods Female heart rate Heart Rate - physiology Humans Male Metabolic Diseases - complications Metabolic Diseases - diagnosis Metabolic Diseases - physiopathology metabolic syndrome Middle Aged Original Paper prehypertension Prehypertension - complications Prehypertension - diagnosis Prehypertension - metabolism Prehypertension - physiopathology Republic of Korea - epidemiology |
| title | Prehypertension is a comorbid state with autonomic and metabolic dysfunction |
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