Antibody-Dependent Natural Killer Cell Activation After Ebola Vaccination

Abstract Background Antibody Fc-mediated functions, such as antibody-dependent cellular cytotoxicity, contribute to vaccine-induced protection against viral infections. Fc-mediated function of anti-Ebola glycoprotein (GP) antibodies suggest that Fc-dependent activation of effector cells, including n...

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Veröffentlicht in:	The Journal of infectious diseases 2021-04, Vol.223 (7), p.1171-1182
Hauptverfasser:	Wagstaffe, Helen R, Clutterbuck, Elizabeth A, Bockstal, Viki, Stoop, Jeroen N, Luhn, Kerstin, Douoguih, Macaya, Shukarev, Georgi, Snape, Matthew D, Pollard, Andrew J, Riley, Eleanor M, Goodier, Martin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Viral - blood Antibody-Dependent Cell Cytotoxicity CD16 antigen Cell activation Cell differentiation Cytotoxicity Ebola Vaccines - immunology Ebola virus Ebolavirus Ebolavirus - immunology Effector cells Glycoproteins - immunology Hemorrhagic Fever, Ebola - prevention & control Humans Immune response Immunization Killer Cells, Natural - immunology Major and Brief Reports Natural killer cells Phenotypes Vaccination Vaccines Vaccinia Viral Proteins - immunology γ-Interferon
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