Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies

Neuronal loss in specific brain regions and neurons with intracellular inclusions termed Lewy bodies are the pathologic hallmark in both Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies comprise of aggregated intracellular vesicles and proteins and α‐synuclein is report...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2017-01, Vol.27 (1), p.3-12
Hauptverfasser:	Power, John H. T., Barnes, Olivia L., Chegini, Fariba
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over alpha synuclein alpha-Synuclein - analysis Apoptosis Biomarkers Cell Death Cell Nucleus - ultrastructure confocal microscopy Dementia Electron Transport Complex IV - analysis Female Humans immunohistochemistry Lewy Bodies - pathology Lewy Body Disease - pathology Male microtubules Microtubules - ultrastructure Middle Aged Mitochondria Mitochondria - ultrastructure Nerve Degeneration - pathology Nerve Tissue Proteins - analysis neurodegeneration Neurons - metabolism Neurons - pathology Parkinson Disease - pathology Parkinson's disease Superoxide Dismutase - analysis
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