Genetic alterations related to BRAF‐FGFR genes and dysregulated MAPK/ERK/mTOR signaling in adult pilocytic astrocytoma

Pilocytic astrocytomas occur rarely in adults and show aggressive tumor behavior. However, their underlying molecular‐genetic events are largely uncharacterized. Hence, 59 adult pilocytic astrocytoma (APA) cases of classical histology were studied (MIB‐1 LI: 1%–5%). Analysis of BRAF alterations usin...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2017-09, Vol.27 (5), p.580-589
Hauptverfasser:	Pathak, Pankaj, Kumar, Anupam, Jha, Prerana, Purkait, Suvendu, Faruq, Mohammed, Suri, Ashish, Suri, Vaishali, Sharma, Mehar C., Sarkar, Chitra
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Methylisoborneol Activation Adult adult pilocytic astrocytoma Adults Age Age Factors Astrocytoma Astrocytoma - genetics Astrocytoma - metabolism Astrocytoma - pathology BRAF Extracellular signal-regulated kinase Female FGFR1 Fibroblast growth factor receptor 1 Fibroblast growth factor receptors Histology Humans Immunoreactivity low grade glioma Male MAP kinase MAP Kinase Signaling System MAPK/ERK Middle Aged mTOR Mutation Polymerase chain reaction Proto-Oncogene Proteins B-raf - genetics Receptor, Fibroblast Growth Factor, Type 1 - genetics Retrospective Studies Signal Transduction Statistical analysis TOR protein TOR Serine-Threonine Kinases - metabolism Tumors Young Adult
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