Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer

Background. The present study is aimed at providing systematic insight into the composition and expression of transfer RNA (tRNA) derivative transcription in high-grade serous ovarian cancer (HGSOC). Methods. tRNA derivative expression profiles in three pairs of HGSOC and adjacent normal ovarian tis...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.5594081-5594081
Hauptverfasser:	Chen, Buze, Liu, Sicong, Wang, Haihong, Li, Guilin, Lu, Xiaoyuan, Xu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Algorithms Biomarkers Biosynthesis Cancer Cancer therapies Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - pathology Derivatives Development and progression Diabetes mellitus Down-Regulation - genetics Elongation Encyclopedias Fatty acids Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Ontology Gene Regulatory Networks Genes Genetic aspects Genetic transcription Genomes Glucagon Glycan Health aspects Humans Insulin Insulin resistance Leukocyte migration Leukocytes Metabolism Middle Aged Molecular Sequence Annotation Mucin Neoplasm Grading Oncology, Experimental Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Pathogenesis Physiological aspects Principal components analysis Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Roles Signal transduction Signaling Starch Statistical analysis Sucrose Therapeutic targets Transcription Transfer RNA tRNA Up-Regulation - genetics
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