A randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-D-aspartate receptor blockade in healthy veterans

The kynurenine pathway (KP) is a strategic metabolic system that combines regulation of neuronal excitability via glutamate receptor function and neuroinflammation via other KP metabolites. This pathway has great promise in treatment of depression and suicidality. The KP modulator AV-101 (4-chloroky...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2021-03, Vol.46 (4), p.820-827
Hauptverfasser:	Murphy, Nicholas, Ramakrishnan, Nithya, Vo-Le, Bylinda, Vo-Le, Brittany, Smith, Mark A, Iqbal, Tabish, Swann, Alan C, Mathew, Sanjay J, Lijffijt, Marijn
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical trials Double-blind studies EEG Excitability Glutamic acid receptors Glycine Inflammation Mental depression Metabolites N-Methyl-D-aspartic acid receptors Placebos Quinolinic acid Suicides & suicide attempts
Online-Zugang:	Volltext
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