Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon

Oral administration of curcumin has been shown to inhibit pulmonary fibrosis (PF) despite its extremely low bioavailability. In this study, we investigated the mechanisms underlying the anti-PF effect of curcumin in focus on intestinal endocrine. In bleomycin- and SiO 2 -treated mice, curcumin (75,...

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Veröffentlicht in:	Acta pharmacologica Sinica 2021-03, Vol.42 (3), p.422-435
Hauptverfasser:	Miao, Yu-meng, Zhang, Ya-jing, Qiao, Si-miao, Xia, Yu-feng, Wei, Zhi-feng, Dai, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Bioavailability Biomedical and Life Sciences Biomedicine Bleomycin c-Met protein Colon Colon - cytology Colon - drug effects Colon - metabolism Curcumin Curcumin - administration & dosage Curcumin - therapeutic use Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Digestive system Epithelial cells Female Fibroblasts Fibroblasts - metabolism Fibrosis Gastrointestinal tract Growth factors Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Humans Immunology Internal Medicine Intestine Lung - drug effects Lung - metabolism Lung - pathology Lung diseases Macrophages Macrophages - metabolism Medical Microbiology Mice Mice, Inbred ICR Monocytes Oral administration Pharmacology/Toxicology PPAR gamma - metabolism Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - metabolism Pulmonary fibrosis Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology RAW 264.7 Cells Silicon dioxide Transcription factors Up-Regulation - drug effects Vaccine
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