Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation

Macrophages acquire anti-inflammatory and proresolving functions to facilitate resolution of inflammation and promote tissue repair. While alternatively activated macrophages (AAMs), also referred to as M2 macrophages, polarized by type 2 (Th2) cytokines IL-4 or IL-13 contribute to the suppression o...

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Veröffentlicht in:	Cell death and differentiation 2021-04, Vol.28 (4), p.1301-1316
Hauptverfasser:	Snodgrass, Ryan G., Benatzy, Yvonne, Schmid, Tobias, Namgaladze, Dmitry, Mainka, Malwina, Schebb, Nils Helge, Lütjohann, Dieter, Brüne, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/2 13/31 13/89 38/39 38/91 631/250/1933 631/250/256/2515 631/45/287/1197 82/58 82/80 Apoptosis Arachidonate 15-lipoxygenase Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - metabolism Biochemistry Biomedical and Life Sciences Cell activation Cell Biology Cell Cycle Analysis Cholesterol Cholesterol - metabolism Cytokines Cytokines - genetics Cytokines - metabolism Fluorocarbons - pharmacology Gene Expression Gene Expression Profiling Humans Immune clearance Inflammation Interleukin 1 Interleukin 1 receptor antagonist Interleukin 13 Interleukin 4 Intermediates Lanosterol Life Sciences Lipid Metabolism Lipoxygenase Liver X receptors Lymphocytes T Lysosomes Macrophages Macrophages - immunology Macrophages - metabolism Npc1 protein Phagocytosis Protein Binding Receptor mechanisms RNA, Small Interfering - genetics Stem Cells Sterol regulatory element-binding protein Sterols Sulfonamides - pharmacology Transcriptomes Wound healing
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