Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice
Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not been investigated. We exposed mice to no-observed-adverse-effect...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2021, Vol.83(3), pp.542-548 |
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| creator | MAEDA, Mizuki KITAUCHI, Sayaka HIRANO, Tetsushi IKENAKA, Yoshinori NISHI, Misaki SHODA, Asuka MURATA, Midori MANTANI, Youhei TABUCHI, Yoshiaki YOKOYAMA, Toshifumi HOSHI, Nobuhiko |
| description | Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not been investigated. We exposed mice to no-observed-adverse-effect level (NOAEL) doses of clothianidin (CLO) during the fetal and lactational period, and then evaluated the neurobehavioral effects in juvenile and adult mice. Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. These results suggest that fetal and lactational exposure to CLO may inhibit neurogenesis and cause different behavioral abnormalities at different developmental stages. |
| doi_str_mv | 10.1292/jvms.20-0721 |
| format | Article |
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We exposed mice to no-observed-adverse-effect level (NOAEL) doses of clothianidin (CLO) during the fetal and lactational period, and then evaluated the neurobehavioral effects in juvenile and adult mice. Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. These results suggest that fetal and lactational exposure to CLO may inhibit neurogenesis and cause different behavioral abnormalities at different developmental stages.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.20-0721</identifier><identifier>PMID: 33518607</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Anxiety ; behavioral test ; clothianidin ; Dentate gyrus ; developmental stage ; Developmental stages ; fetal and lactational exposure ; Fetuses ; Hippocampus ; Juveniles ; Locomotor activity ; Neurogenesis ; Pesticides ; Toxicology</subject><ispartof>Journal of Veterinary Medical Science, 2021, Vol.83(3), pp.542-548</ispartof><rights>2021 by the Japanese Society of Veterinary Science</rights><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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Vet. Med. Sci.</addtitle><description>Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not been investigated. We exposed mice to no-observed-adverse-effect level (NOAEL) doses of clothianidin (CLO) during the fetal and lactational period, and then evaluated the neurobehavioral effects in juvenile and adult mice. Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. These results suggest that fetal and lactational exposure to CLO may inhibit neurogenesis and cause different behavioral abnormalities at different developmental stages.</description><subject>Anxiety</subject><subject>behavioral test</subject><subject>clothianidin</subject><subject>Dentate gyrus</subject><subject>developmental stage</subject><subject>Developmental stages</subject><subject>fetal and lactational exposure</subject><subject>Fetuses</subject><subject>Hippocampus</subject><subject>Juveniles</subject><subject>Locomotor activity</subject><subject>Neurogenesis</subject><subject>Pesticides</subject><subject>Toxicology</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkk2LFDEQhhtR3HX15lkCXhTsNR_9MbkI67KrwuBe9BzSSfV0DT3JmKQb_dH-B9Mz46CXhFBP3velqoriJaPXjEv-fjvv4jWnJW05e1RcMlG1ZVsJ-bi4pJI1ZctrelE8i3FLKWdVI58WF0LUbNXQ9rL4fQ9Jj0Q7S0Ztkk7oXX7Dz72PUwCSPEkDEOdL30UIM9hS2xlChBL6HkwiI8wwkjdfH27u1m-J9RGI74-fwDs0PqHzaMkeYkKDFogZfRpQO7ToCLoBO0wx01PwG3AQMR7yoLOTgUgsZqMALpEOBj2jD0vgzvmw0yMmzIhOB0O7RPH7XWYzEpPe5Fr2yByQHRp4Xjzp9Rjhxem-Kr7f3327_VyuHz59ub1Zl6ahdSorxmthOONVw2rGQLDc1aajuqtaKinVPRMdNFUlLUjJq9Y0LfRSUy4oGC7FVfHhqLufuh1YkwPl0GofcKfDL-U1qv8rDge18bNaUV5XdJUFXp8Egv8x5c6prZ9CnkxUeZytlLJZ0Uy9O1Im-BgD9GcHRtWyHGpZDsWpWpYj46_-TXWG_25DBj4ege2hd2dAhzy5EY5qK6HEcpxUz0Uz6KDAiT85W9RP</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>MAEDA, Mizuki</creator><creator>KITAUCHI, Sayaka</creator><creator>HIRANO, Tetsushi</creator><creator>IKENAKA, Yoshinori</creator><creator>NISHI, Misaki</creator><creator>SHODA, Asuka</creator><creator>MURATA, Midori</creator><creator>MANTANI, Youhei</creator><creator>TABUCHI, Yoshiaki</creator><creator>YOKOYAMA, Toshifumi</creator><creator>HOSHI, Nobuhiko</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20210301</creationdate><title>Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice</title><author>MAEDA, Mizuki ; KITAUCHI, Sayaka ; HIRANO, Tetsushi ; IKENAKA, Yoshinori ; NISHI, Misaki ; SHODA, Asuka ; MURATA, Midori ; MANTANI, Youhei ; TABUCHI, Yoshiaki ; YOKOYAMA, Toshifumi ; HOSHI, Nobuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-41253c212461511e311346b0ab470900af13be6449de99247c67ef9a0230ec293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anxiety</topic><topic>behavioral test</topic><topic>clothianidin</topic><topic>Dentate gyrus</topic><topic>developmental stage</topic><topic>Developmental stages</topic><topic>fetal and lactational exposure</topic><topic>Fetuses</topic><topic>Hippocampus</topic><topic>Juveniles</topic><topic>Locomotor activity</topic><topic>Neurogenesis</topic><topic>Pesticides</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAEDA, Mizuki</creatorcontrib><creatorcontrib>KITAUCHI, Sayaka</creatorcontrib><creatorcontrib>HIRANO, Tetsushi</creatorcontrib><creatorcontrib>IKENAKA, Yoshinori</creatorcontrib><creatorcontrib>NISHI, Misaki</creatorcontrib><creatorcontrib>SHODA, Asuka</creatorcontrib><creatorcontrib>MURATA, Midori</creatorcontrib><creatorcontrib>MANTANI, Youhei</creatorcontrib><creatorcontrib>TABUCHI, Yoshiaki</creatorcontrib><creatorcontrib>YOKOYAMA, Toshifumi</creatorcontrib><creatorcontrib>HOSHI, Nobuhiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAEDA, Mizuki</au><au>KITAUCHI, Sayaka</au><au>HIRANO, Tetsushi</au><au>IKENAKA, Yoshinori</au><au>NISHI, Misaki</au><au>SHODA, Asuka</au><au>MURATA, Midori</au><au>MANTANI, Youhei</au><au>TABUCHI, Yoshiaki</au><au>YOKOYAMA, Toshifumi</au><au>HOSHI, Nobuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. 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| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Anxiety behavioral test clothianidin Dentate gyrus developmental stage Developmental stages fetal and lactational exposure Fetuses Hippocampus Juveniles Locomotor activity Neurogenesis Pesticides Toxicology |
| title | Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice |
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