Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation
The ability of neural stem cells (NSCs) to switch between quiescence and proliferation is crucial for brain development and homeostasis. Increasing evidence suggests that variants of histone lysine methyltransferases including KMT5A are associated with neurodevelopmental disorders. However, the func...
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| Veröffentlicht in: | EMBO reports 2021-04, Vol.22 (4), p.e50994-n/a |
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| creator | Huang, Jiawen Gujar, Mahekta R Deng, Qiannan Y Chia, Sook Li, Song Tan, Patrick Sung, Wing-Kin Wang, Hongyan |
| description | The ability of neural stem cells (NSCs) to switch between quiescence and proliferation is crucial for brain development and homeostasis. Increasing evidence suggests that variants of histone lysine methyltransferases including KMT5A are associated with neurodevelopmental disorders. However, the function of KMT5A/Pr-set7/SETD8 in the central nervous system is not well established. Here, we show that
Drosophila
Pr-Set7 is a novel regulator of NSC reactivation. Loss of function of
pr-set7
causes a delay in NSC reactivation and loss of H4K20 monomethylation in the brain. Through NSC-specific
in vivo
profiling, we demonstrate that Pr-set7 binds to the promoter region of
cyclin-dependent kinase 1
(
cdk1
) and Wnt pathway transcriptional co-activator
earthbound1/jerky
(
ebd1
). Further validation indicates that Pr-set7 is required for the expression of
cdk1
and
ebd1
in the brain. Similar to Pr-set7, Cdk1 and Ebd1 promote NSC reactivation. Finally, overexpression of Cdk1 and Ebd1 significantly suppressed NSC reactivation defects observed in
pr-set7
-depleted brains. Therefore, Pr-set7 promotes NSC reactivation by regulating Wnt signaling and cell cycle progression. Our findings may contribute to the understanding of mammalian KMT5A/PR-SET7/SETD8 during brain development.
Synopsis
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.
Histone monomethyl transferase Pr-set7 promotes cell cycle re-entry of
Drosophila
neural stem cells from quiescence.
Pr-set7 binds to the promoter region of Cdk1 and the Wnt pathway transcriptional co-activator Ebd1 in neural stem cells.
Pr-set7 functions upstream of cdk1 and ebd1 to promote neural stem cell reactivation.
Graphical Abstract
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1. |
| doi_str_mv | 10.15252/embr.202050994 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8024890</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2509293131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5134-8abf028c86f3cb4ecfe894c2dca9b684d611e16ed1d74e92ec3ec23334b90a163</originalsourceid><addsrcrecordid>eNqFkc9rFDEcxYMotq6evcmAFy_Tza_JJh6EWtdWaFG0BW8hk_lOmzKTrEmmsv-9aXfdVkEkh28gn-_jvTyEXhJ8QBra0DmMbTygmOIGK8UfoX3ChaoZWcjH2zul5PseepbSNca4UQv5FO0x1oiGErKPLk5cysFDNayTK2OEfLUecjQ-9RBNgupLrBPkxfzb8vyDrFYxjCFDqjxM0QxVyjBWFoahimBsdjcmu-Cfoye9GRK82M4Zuvi4PD86qU8_H386OjytbUMYr6Vpe0yllaJntuVge5CKW9pZo1oheScIASKgI92Cg6JgGVjKGOOtwoYINkPvNrqrqR2hs-CL80GvohtNXOtgnP7zxbsrfRlutMSUS4WLwJutQAw_JkhZjy7dxjEewpR0oSQRCgtZ0Nd_oddhir7E07R8PlWMlDND8w1lY0gpQr8zQ7C-q0zfVqZ3lZWNVw8z7PjfHRXg7Qb46QZY_09PL8_ef32ojjfLqez5S4j3rv9l6BfRWbTZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509293131</pqid></control><display><type>article</type><title>Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><creator>Huang, Jiawen ; Gujar, Mahekta R ; Deng, Qiannan ; Y Chia, Sook ; Li, Song ; Tan, Patrick ; Sung, Wing-Kin ; Wang, Hongyan</creator><creatorcontrib>Huang, Jiawen ; Gujar, Mahekta R ; Deng, Qiannan ; Y Chia, Sook ; Li, Song ; Tan, Patrick ; Sung, Wing-Kin ; Wang, Hongyan</creatorcontrib><description>The ability of neural stem cells (NSCs) to switch between quiescence and proliferation is crucial for brain development and homeostasis. Increasing evidence suggests that variants of histone lysine methyltransferases including KMT5A are associated with neurodevelopmental disorders. However, the function of KMT5A/Pr-set7/SETD8 in the central nervous system is not well established. Here, we show that
Drosophila
Pr-Set7 is a novel regulator of NSC reactivation. Loss of function of
pr-set7
causes a delay in NSC reactivation and loss of H4K20 monomethylation in the brain. Through NSC-specific
in vivo
profiling, we demonstrate that Pr-set7 binds to the promoter region of
cyclin-dependent kinase 1
(
cdk1
) and Wnt pathway transcriptional co-activator
earthbound1/jerky
(
ebd1
). Further validation indicates that Pr-set7 is required for the expression of
cdk1
and
ebd1
in the brain. Similar to Pr-set7, Cdk1 and Ebd1 promote NSC reactivation. Finally, overexpression of Cdk1 and Ebd1 significantly suppressed NSC reactivation defects observed in
pr-set7
-depleted brains. Therefore, Pr-set7 promotes NSC reactivation by regulating Wnt signaling and cell cycle progression. Our findings may contribute to the understanding of mammalian KMT5A/PR-SET7/SETD8 during brain development.
Synopsis
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.
Histone monomethyl transferase Pr-set7 promotes cell cycle re-entry of
Drosophila
neural stem cells from quiescence.
Pr-set7 binds to the promoter region of Cdk1 and the Wnt pathway transcriptional co-activator Ebd1 in neural stem cells.
Pr-set7 functions upstream of cdk1 and ebd1 to promote neural stem cell reactivation.
Graphical Abstract
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.</description><identifier>ISSN: 1469-221X</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.15252/embr.202050994</identifier><identifier>PMID: 33565211</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Brain ; CDC2 Protein Kinase ; Cell cycle ; Cell proliferation ; Central nervous system ; Drosophila ; EMBO09 ; EMBO27 ; EMBO34 ; Fruit flies ; Histone methyltransferase ; Histone-Lysine N-Methyltransferase - genetics ; Histone-Lysine N-Methyltransferase - metabolism ; Histones ; Homeostasis ; Insects ; Kinases ; Lysine ; Methyltransferase ; neural stem cell ; Neural stem cells ; Neural Stem Cells - metabolism ; Neurodevelopmental disorders ; Pr‐set7 ; quiescence ; reactivation ; Stem cells ; Transcription ; Wnt protein</subject><ispartof>EMBO reports, 2021-04, Vol.22 (4), p.e50994-n/a</ispartof><rights>The Author(s) 2021</rights><rights>2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license</rights><rights>2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5134-8abf028c86f3cb4ecfe894c2dca9b684d611e16ed1d74e92ec3ec23334b90a163</citedby><cites>FETCH-LOGICAL-c5134-8abf028c86f3cb4ecfe894c2dca9b684d611e16ed1d74e92ec3ec23334b90a163</cites><orcidid>0000-0002-5340-2770 ; 0000-0003-4623-1878</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024890/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024890/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,41120,42189,45574,45575,46409,46833,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33565211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jiawen</creatorcontrib><creatorcontrib>Gujar, Mahekta R</creatorcontrib><creatorcontrib>Deng, Qiannan</creatorcontrib><creatorcontrib>Y Chia, Sook</creatorcontrib><creatorcontrib>Li, Song</creatorcontrib><creatorcontrib>Tan, Patrick</creatorcontrib><creatorcontrib>Sung, Wing-Kin</creatorcontrib><creatorcontrib>Wang, Hongyan</creatorcontrib><title>Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>The ability of neural stem cells (NSCs) to switch between quiescence and proliferation is crucial for brain development and homeostasis. Increasing evidence suggests that variants of histone lysine methyltransferases including KMT5A are associated with neurodevelopmental disorders. However, the function of KMT5A/Pr-set7/SETD8 in the central nervous system is not well established. Here, we show that
Drosophila
Pr-Set7 is a novel regulator of NSC reactivation. Loss of function of
pr-set7
causes a delay in NSC reactivation and loss of H4K20 monomethylation in the brain. Through NSC-specific
in vivo
profiling, we demonstrate that Pr-set7 binds to the promoter region of
cyclin-dependent kinase 1
(
cdk1
) and Wnt pathway transcriptional co-activator
earthbound1/jerky
(
ebd1
). Further validation indicates that Pr-set7 is required for the expression of
cdk1
and
ebd1
in the brain. Similar to Pr-set7, Cdk1 and Ebd1 promote NSC reactivation. Finally, overexpression of Cdk1 and Ebd1 significantly suppressed NSC reactivation defects observed in
pr-set7
-depleted brains. Therefore, Pr-set7 promotes NSC reactivation by regulating Wnt signaling and cell cycle progression. Our findings may contribute to the understanding of mammalian KMT5A/PR-SET7/SETD8 during brain development.
Synopsis
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.
Histone monomethyl transferase Pr-set7 promotes cell cycle re-entry of
Drosophila
neural stem cells from quiescence.
Pr-set7 binds to the promoter region of Cdk1 and the Wnt pathway transcriptional co-activator Ebd1 in neural stem cells.
Pr-set7 functions upstream of cdk1 and ebd1 to promote neural stem cell reactivation.
Graphical Abstract
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.</description><subject>Animals</subject><subject>Brain</subject><subject>CDC2 Protein Kinase</subject><subject>Cell cycle</subject><subject>Cell proliferation</subject><subject>Central nervous system</subject><subject>Drosophila</subject><subject>EMBO09</subject><subject>EMBO27</subject><subject>EMBO34</subject><subject>Fruit flies</subject><subject>Histone methyltransferase</subject><subject>Histone-Lysine N-Methyltransferase - genetics</subject><subject>Histone-Lysine N-Methyltransferase - metabolism</subject><subject>Histones</subject><subject>Homeostasis</subject><subject>Insects</subject><subject>Kinases</subject><subject>Lysine</subject><subject>Methyltransferase</subject><subject>neural stem cell</subject><subject>Neural stem cells</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neurodevelopmental disorders</subject><subject>Pr‐set7</subject><subject>quiescence</subject><subject>reactivation</subject><subject>Stem cells</subject><subject>Transcription</subject><subject>Wnt protein</subject><issn>1469-221X</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFkc9rFDEcxYMotq6evcmAFy_Tza_JJh6EWtdWaFG0BW8hk_lOmzKTrEmmsv-9aXfdVkEkh28gn-_jvTyEXhJ8QBra0DmMbTygmOIGK8UfoX3ChaoZWcjH2zul5PseepbSNca4UQv5FO0x1oiGErKPLk5cysFDNayTK2OEfLUecjQ-9RBNgupLrBPkxfzb8vyDrFYxjCFDqjxM0QxVyjBWFoahimBsdjcmu-Cfoye9GRK82M4Zuvi4PD86qU8_H386OjytbUMYr6Vpe0yllaJntuVge5CKW9pZo1oheScIASKgI92Cg6JgGVjKGOOtwoYINkPvNrqrqR2hs-CL80GvohtNXOtgnP7zxbsrfRlutMSUS4WLwJutQAw_JkhZjy7dxjEewpR0oSQRCgtZ0Nd_oddhir7E07R8PlWMlDND8w1lY0gpQr8zQ7C-q0zfVqZ3lZWNVw8z7PjfHRXg7Qb46QZY_09PL8_ef32ojjfLqez5S4j3rv9l6BfRWbTZ</recordid><startdate>20210407</startdate><enddate>20210407</enddate><creator>Huang, Jiawen</creator><creator>Gujar, Mahekta R</creator><creator>Deng, Qiannan</creator><creator>Y Chia, Sook</creator><creator>Li, Song</creator><creator>Tan, Patrick</creator><creator>Sung, Wing-Kin</creator><creator>Wang, Hongyan</creator><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>C6C</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5340-2770</orcidid><orcidid>https://orcid.org/0000-0003-4623-1878</orcidid></search><sort><creationdate>20210407</creationdate><title>Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation</title><author>Huang, Jiawen ; Gujar, Mahekta R ; Deng, Qiannan ; Y Chia, Sook ; Li, Song ; Tan, Patrick ; Sung, Wing-Kin ; Wang, Hongyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5134-8abf028c86f3cb4ecfe894c2dca9b684d611e16ed1d74e92ec3ec23334b90a163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Brain</topic><topic>CDC2 Protein Kinase</topic><topic>Cell cycle</topic><topic>Cell proliferation</topic><topic>Central nervous system</topic><topic>Drosophila</topic><topic>EMBO09</topic><topic>EMBO27</topic><topic>EMBO34</topic><topic>Fruit flies</topic><topic>Histone methyltransferase</topic><topic>Histone-Lysine N-Methyltransferase - genetics</topic><topic>Histone-Lysine N-Methyltransferase - metabolism</topic><topic>Histones</topic><topic>Homeostasis</topic><topic>Insects</topic><topic>Kinases</topic><topic>Lysine</topic><topic>Methyltransferase</topic><topic>neural stem cell</topic><topic>Neural stem cells</topic><topic>Neural Stem Cells - metabolism</topic><topic>Neurodevelopmental disorders</topic><topic>Pr‐set7</topic><topic>quiescence</topic><topic>reactivation</topic><topic>Stem cells</topic><topic>Transcription</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Jiawen</creatorcontrib><creatorcontrib>Gujar, Mahekta R</creatorcontrib><creatorcontrib>Deng, Qiannan</creatorcontrib><creatorcontrib>Y Chia, Sook</creatorcontrib><creatorcontrib>Li, Song</creatorcontrib><creatorcontrib>Tan, Patrick</creatorcontrib><creatorcontrib>Sung, Wing-Kin</creatorcontrib><creatorcontrib>Wang, Hongyan</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jiawen</au><au>Gujar, Mahekta R</au><au>Deng, Qiannan</au><au>Y Chia, Sook</au><au>Li, Song</au><au>Tan, Patrick</au><au>Sung, Wing-Kin</au><au>Wang, Hongyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation</atitle><jtitle>EMBO reports</jtitle><stitle>EMBO Rep</stitle><addtitle>EMBO Rep</addtitle><date>2021-04-07</date><risdate>2021</risdate><volume>22</volume><issue>4</issue><spage>e50994</spage><epage>n/a</epage><pages>e50994-n/a</pages><issn>1469-221X</issn><eissn>1469-3178</eissn><abstract>The ability of neural stem cells (NSCs) to switch between quiescence and proliferation is crucial for brain development and homeostasis. Increasing evidence suggests that variants of histone lysine methyltransferases including KMT5A are associated with neurodevelopmental disorders. However, the function of KMT5A/Pr-set7/SETD8 in the central nervous system is not well established. Here, we show that
Drosophila
Pr-Set7 is a novel regulator of NSC reactivation. Loss of function of
pr-set7
causes a delay in NSC reactivation and loss of H4K20 monomethylation in the brain. Through NSC-specific
in vivo
profiling, we demonstrate that Pr-set7 binds to the promoter region of
cyclin-dependent kinase 1
(
cdk1
) and Wnt pathway transcriptional co-activator
earthbound1/jerky
(
ebd1
). Further validation indicates that Pr-set7 is required for the expression of
cdk1
and
ebd1
in the brain. Similar to Pr-set7, Cdk1 and Ebd1 promote NSC reactivation. Finally, overexpression of Cdk1 and Ebd1 significantly suppressed NSC reactivation defects observed in
pr-set7
-depleted brains. Therefore, Pr-set7 promotes NSC reactivation by regulating Wnt signaling and cell cycle progression. Our findings may contribute to the understanding of mammalian KMT5A/PR-SET7/SETD8 during brain development.
Synopsis
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.
Histone monomethyl transferase Pr-set7 promotes cell cycle re-entry of
Drosophila
neural stem cells from quiescence.
Pr-set7 binds to the promoter region of Cdk1 and the Wnt pathway transcriptional co-activator Ebd1 in neural stem cells.
Pr-set7 functions upstream of cdk1 and ebd1 to promote neural stem cell reactivation.
Graphical Abstract
Histone monomethyl transferase Pr-set7 is required for
Drosophila
neural stem cells to exit from quiescence. Pr-set7 promotes stem cell reactivation by upregulating the cell cycle regulator Cdk1 and the Wnt pathway transcriptional co-activator Ebd1.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33565211</pmid><doi>10.15252/embr.202050994</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-5340-2770</orcidid><orcidid>https://orcid.org/0000-0003-4623-1878</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Wiley Online Library All Journals; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Animals Brain CDC2 Protein Kinase Cell cycle Cell proliferation Central nervous system Drosophila EMBO09 EMBO27 EMBO34 Fruit flies Histone methyltransferase Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones Homeostasis Insects Kinases Lysine Methyltransferase neural stem cell Neural stem cells Neural Stem Cells - metabolism Neurodevelopmental disorders Pr‐set7 quiescence reactivation Stem cells Transcription Wnt protein |
| title | Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation |
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