Risk factors of left atrial appendage thrombus in patients with non-valvular atrial fibrillation
To investigate the risk factors of left atrial appendage thrombus (LAAT) in patients with non-valvular atrial fibrillation (AF). We collected the clinical data of patients with non-valvular AF who underwent transesophageal echocardiography (TEE) at the Zhongda Hospital of Southeast University betwee...
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| Veröffentlicht in: | Open medicine (Warsaw, Poland) Poland), 2021-03, Vol.16 (1), p.361-366 |
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| creator | Liu, Yaowu Zhu, Didi Xiao, Yunyun Zhu, Yeqian Zhou, Qianxing Ren, Liqun Chen, Long |
| description | To investigate the risk factors of left atrial appendage thrombus (LAAT) in patients with non-valvular atrial fibrillation (AF).
We collected the clinical data of patients with non-valvular AF who underwent transesophageal echocardiography (TEE) at the Zhongda Hospital of Southeast University between January 2016 and June 2019. The patients were divided into two groups, LAAT and non-LAAT. We performed comparative analysis, receiver operating characteristic (ROC) curve analysis and logistic regression analysis to estimate the risk factors of LAAT.
A total of 442 patients with non-valvular AF were enrolled in the study. LAAT was detected by TEE in 20 cases (4.7%). Compared with patients without LAAT, patients with LAAT had higher CHA
DS
-VASc scores (3 vs 2,
= 0.001), higher values of D-dimer (180.0 vs 90.0 μg/L,
= 0.003), larger LA anteroposterior diameters (50.5 vs 41.0 mm,
< 0.001) and higher ratios of non-paroxysmal AF (85.0% vs 23.6%,
< 0.001). ROC curve analysis revealed that the cutoff value of LA anteroposterior diameter was 49.5 mm. After adjusting for other confounders, logistic regression analysis showed that enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independently associated with higher risks of LAAT (OR = 7.28, 95% CI: 2.36-22.47; OR = 8.89, 95% CI: 2.33-33.99, respectively). The proportions of LAAT in patients with larger LA (anteroposterior diameter ≥49.5 mm), non-paroxysmal AF and both larger LA and non-paroxysmal AF were 30% (12/40), 15.2% (17/112) and 39.1% (9/23), respectively.
Enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independent risk factors of LAAT in non-valvular AF patients. |
| doi_str_mv | 10.1515/med-2021-0009 |
| format | Article |
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We collected the clinical data of patients with non-valvular AF who underwent transesophageal echocardiography (TEE) at the Zhongda Hospital of Southeast University between January 2016 and June 2019. The patients were divided into two groups, LAAT and non-LAAT. We performed comparative analysis, receiver operating characteristic (ROC) curve analysis and logistic regression analysis to estimate the risk factors of LAAT.
A total of 442 patients with non-valvular AF were enrolled in the study. LAAT was detected by TEE in 20 cases (4.7%). Compared with patients without LAAT, patients with LAAT had higher CHA
DS
-VASc scores (3 vs 2,
= 0.001), higher values of D-dimer (180.0 vs 90.0 μg/L,
= 0.003), larger LA anteroposterior diameters (50.5 vs 41.0 mm,
< 0.001) and higher ratios of non-paroxysmal AF (85.0% vs 23.6%,
< 0.001). ROC curve analysis revealed that the cutoff value of LA anteroposterior diameter was 49.5 mm. After adjusting for other confounders, logistic regression analysis showed that enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independently associated with higher risks of LAAT (OR = 7.28, 95% CI: 2.36-22.47; OR = 8.89, 95% CI: 2.33-33.99, respectively). The proportions of LAAT in patients with larger LA (anteroposterior diameter ≥49.5 mm), non-paroxysmal AF and both larger LA and non-paroxysmal AF were 30% (12/40), 15.2% (17/112) and 39.1% (9/23), respectively.
Enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independent risk factors of LAAT in non-valvular AF patients.</description><identifier>ISSN: 2391-5463</identifier><identifier>EISSN: 2391-5463</identifier><identifier>DOI: 10.1515/med-2021-0009</identifier><identifier>PMID: 33869773</identifier><language>eng</language><publisher>Poland: De Gruyter</publisher><subject>atrial fibrillation ; Blood clots ; Cardiac arrhythmia ; left atrial appendage thrombus ; Regression analysis ; Risk factors</subject><ispartof>Open medicine (Warsaw, Poland), 2021-03, Vol.16 (1), p.361-366</ispartof><rights>2021 Yaowu Liu et al., published by De Gruyter.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Yaowu Liu ., published by De Gruyter 2021 Yaowu Liu et al., published by De Gruyter</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-a914dafe7692c58f0d27eaa45dcd0a65e0821fe2cbc60789f3fd7f38ba982bb23</citedby><cites>FETCH-LOGICAL-c500t-a914dafe7692c58f0d27eaa45dcd0a65e0821fe2cbc60789f3fd7f38ba982bb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024551/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024551/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27924,27925,53791,53793,67158,68942</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33869773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yaowu</creatorcontrib><creatorcontrib>Zhu, Didi</creatorcontrib><creatorcontrib>Xiao, Yunyun</creatorcontrib><creatorcontrib>Zhu, Yeqian</creatorcontrib><creatorcontrib>Zhou, Qianxing</creatorcontrib><creatorcontrib>Ren, Liqun</creatorcontrib><creatorcontrib>Chen, Long</creatorcontrib><title>Risk factors of left atrial appendage thrombus in patients with non-valvular atrial fibrillation</title><title>Open medicine (Warsaw, Poland)</title><addtitle>Open Med (Wars)</addtitle><description>To investigate the risk factors of left atrial appendage thrombus (LAAT) in patients with non-valvular atrial fibrillation (AF).
We collected the clinical data of patients with non-valvular AF who underwent transesophageal echocardiography (TEE) at the Zhongda Hospital of Southeast University between January 2016 and June 2019. The patients were divided into two groups, LAAT and non-LAAT. We performed comparative analysis, receiver operating characteristic (ROC) curve analysis and logistic regression analysis to estimate the risk factors of LAAT.
A total of 442 patients with non-valvular AF were enrolled in the study. LAAT was detected by TEE in 20 cases (4.7%). Compared with patients without LAAT, patients with LAAT had higher CHA
DS
-VASc scores (3 vs 2,
= 0.001), higher values of D-dimer (180.0 vs 90.0 μg/L,
= 0.003), larger LA anteroposterior diameters (50.5 vs 41.0 mm,
< 0.001) and higher ratios of non-paroxysmal AF (85.0% vs 23.6%,
< 0.001). ROC curve analysis revealed that the cutoff value of LA anteroposterior diameter was 49.5 mm. After adjusting for other confounders, logistic regression analysis showed that enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independently associated with higher risks of LAAT (OR = 7.28, 95% CI: 2.36-22.47; OR = 8.89, 95% CI: 2.33-33.99, respectively). The proportions of LAAT in patients with larger LA (anteroposterior diameter ≥49.5 mm), non-paroxysmal AF and both larger LA and non-paroxysmal AF were 30% (12/40), 15.2% (17/112) and 39.1% (9/23), respectively.
Enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independent risk factors of LAAT in non-valvular AF patients.</description><subject>atrial fibrillation</subject><subject>Blood clots</subject><subject>Cardiac arrhythmia</subject><subject>left atrial appendage thrombus</subject><subject>Regression analysis</subject><subject>Risk factors</subject><issn>2391-5463</issn><issn>2391-5463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkd1rHCEUxYfS0IQ0j30tQp-n9WPUkUKhhH4EAoWSPJs7o-66dcepOhvy39ftJmkCBcGL_jzHe0_TvCH4PeGEf9ha01JMSYsxVi-aE8oUaXkn2Msn9XFzlvOmEoQzqSR-1Rwz1gslJTtpbn76_As5GEtMGUWHgnUFQUkeAoJ5tpOBlUVlneJ2WDLyE5qheDuVjG59WaMpTu0Owm4JkB7eOT8kH0Ll4vS6OXIQsj2730-b669frs6_t5c_vl2cf75sR45xaUGRzoCzUig68t5hQ6UF6LgZDQbBLe4pcZaOwyiw7JVjzkjH-gFUT4eBstPm4qBrImz0nPwW0p2O4PXfg5hWGlLxY7DaKKimTHTEuI4CBmBmGERvgFJFLa5anw5a8zLUEY-12wThmejzm8mv9SrudI9pxzmpAu_uBVL8vdhc9CYuaar9a9opKWidf1ep9kCNKeacrHt0IFjv89XVQu_z1ft8K__26bce6Yc0K_DxANxCKDYZu0rLXS3-uf9XmAjC6voDNLO24A</recordid><startdate>20210303</startdate><enddate>20210303</enddate><creator>Liu, Yaowu</creator><creator>Zhu, Didi</creator><creator>Xiao, Yunyun</creator><creator>Zhu, Yeqian</creator><creator>Zhou, Qianxing</creator><creator>Ren, Liqun</creator><creator>Chen, Long</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210303</creationdate><title>Risk factors of left atrial appendage thrombus in patients with non-valvular atrial fibrillation</title><author>Liu, Yaowu ; Zhu, Didi ; Xiao, Yunyun ; Zhu, Yeqian ; Zhou, Qianxing ; Ren, Liqun ; Chen, Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-a914dafe7692c58f0d27eaa45dcd0a65e0821fe2cbc60789f3fd7f38ba982bb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>atrial fibrillation</topic><topic>Blood clots</topic><topic>Cardiac arrhythmia</topic><topic>left atrial appendage thrombus</topic><topic>Regression analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yaowu</creatorcontrib><creatorcontrib>Zhu, Didi</creatorcontrib><creatorcontrib>Xiao, Yunyun</creatorcontrib><creatorcontrib>Zhu, Yeqian</creatorcontrib><creatorcontrib>Zhou, Qianxing</creatorcontrib><creatorcontrib>Ren, Liqun</creatorcontrib><creatorcontrib>Chen, Long</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Open medicine (Warsaw, Poland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yaowu</au><au>Zhu, Didi</au><au>Xiao, Yunyun</au><au>Zhu, Yeqian</au><au>Zhou, Qianxing</au><au>Ren, Liqun</au><au>Chen, Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors of left atrial appendage thrombus in patients with non-valvular atrial fibrillation</atitle><jtitle>Open medicine (Warsaw, Poland)</jtitle><addtitle>Open Med (Wars)</addtitle><date>2021-03-03</date><risdate>2021</risdate><volume>16</volume><issue>1</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>2391-5463</issn><eissn>2391-5463</eissn><abstract>To investigate the risk factors of left atrial appendage thrombus (LAAT) in patients with non-valvular atrial fibrillation (AF).
We collected the clinical data of patients with non-valvular AF who underwent transesophageal echocardiography (TEE) at the Zhongda Hospital of Southeast University between January 2016 and June 2019. The patients were divided into two groups, LAAT and non-LAAT. We performed comparative analysis, receiver operating characteristic (ROC) curve analysis and logistic regression analysis to estimate the risk factors of LAAT.
A total of 442 patients with non-valvular AF were enrolled in the study. LAAT was detected by TEE in 20 cases (4.7%). Compared with patients without LAAT, patients with LAAT had higher CHA
DS
-VASc scores (3 vs 2,
= 0.001), higher values of D-dimer (180.0 vs 90.0 μg/L,
= 0.003), larger LA anteroposterior diameters (50.5 vs 41.0 mm,
< 0.001) and higher ratios of non-paroxysmal AF (85.0% vs 23.6%,
< 0.001). ROC curve analysis revealed that the cutoff value of LA anteroposterior diameter was 49.5 mm. After adjusting for other confounders, logistic regression analysis showed that enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independently associated with higher risks of LAAT (OR = 7.28, 95% CI: 2.36-22.47; OR = 8.89, 95% CI: 2.33-33.99, respectively). The proportions of LAAT in patients with larger LA (anteroposterior diameter ≥49.5 mm), non-paroxysmal AF and both larger LA and non-paroxysmal AF were 30% (12/40), 15.2% (17/112) and 39.1% (9/23), respectively.
Enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independent risk factors of LAAT in non-valvular AF patients.</abstract><cop>Poland</cop><pub>De Gruyter</pub><pmid>33869773</pmid><doi>10.1515/med-2021-0009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | De Gruyter Open Access Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | atrial fibrillation Blood clots Cardiac arrhythmia left atrial appendage thrombus Regression analysis Risk factors |
| title | Risk factors of left atrial appendage thrombus in patients with non-valvular atrial fibrillation |
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