Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis
Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-desi...
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| Veröffentlicht in: | Heart failure reviews 2021-05, Vol.26 (3), p.577-585 |
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| creator | Wobbe, Bastian Wagner, Juliane Szabó, Dorottya Kata Rostás, Ildikó Farkas, Nelli Garami, András Balaskó, Márta Hartmann, Petra Solymár, Margit Tenk, Judit Ottóffy, Máté Nagy, Arnold Habon, Tamás Hegyi, Péter Czopf, László |
| description | Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL;
p
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| doi_str_mv | 10.1007/s10741-020-10057-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8024232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2465438724</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-9b27219a1ebb4c6bd42b83e53b74bd1d7657ce0d38de8f6682612d7b44623ca3</originalsourceid><addsrcrecordid>eNp9UctuFDEQtBCIhMAPcECWuHAx8WvGMxyQUMRLipRLcrb86Mk68owX27PS_j1eNoTHIRfbra6q7nIh9JrR94xSdV4YVZIRyilpdaeIeoJOWacEUYLzp-0tBk4kk-oEvSjljlIqR0mfoxMhuJR915-ichNrNlM4nDWkBYeCLdQKGdeNWbAPa4YaXKsgm-0eTynjXYrrDCTtIMdkPHhs3FoBb8DkiicTYiPhbROEpZYP2OAZqiFmMXFfQnmJnk0mFnh1f5-h6y-fry--kcurr98vPl0SJ5WsZLRccTYaBtZK11svuR0EdMIqaT3zqu-UA-rF4GGY-n7gPeNe2eaMC2fEGfp4lN2udgbv2i7ZRL3NYTZ5r5MJ-t_OEjb6Nu30QLnkgjeBd_cCOf1YoVQ9h-IgRrNAWovm7QulGBSXDfr2P-hdWnPz21AdHRkde3oQ5EeUy6mUDNPDMozqQ6T6GKlukepfkWrVSG_-tvFA-Z1hA4gjoLTWcgv5z-xHZH8C_06u_A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509109602</pqid></control><display><type>article</type><title>Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis</title><source>SpringerLink Journals</source><creator>Wobbe, Bastian ; Wagner, Juliane ; Szabó, Dorottya Kata ; Rostás, Ildikó ; Farkas, Nelli ; Garami, András ; Balaskó, Márta ; Hartmann, Petra ; Solymár, Margit ; Tenk, Judit ; Ottóffy, Máté ; Nagy, Arnold ; Habon, Tamás ; Hegyi, Péter ; Czopf, László</creator><creatorcontrib>Wobbe, Bastian ; Wagner, Juliane ; Szabó, Dorottya Kata ; Rostás, Ildikó ; Farkas, Nelli ; Garami, András ; Balaskó, Márta ; Hartmann, Petra ; Solymár, Margit ; Tenk, Judit ; Ottóffy, Máté ; Nagy, Arnold ; Habon, Tamás ; Hegyi, Péter ; Czopf, László</creatorcontrib><description>Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL;
p
< 0.001), weight loss (difference in means 1.592 kg, 95% CI 1.039 to 2.144 kg;
p
< 0.001) and lower incidences of worsening heart failure (OR 0.63, 95% CI 0.43 to 0.94,
p
= 0.022) and rehospitalization for heart failure (OR 0.54, 95% CI 0.36 to 0.82,
p
= 0.003) without a difference in renal impairment (OR 1.386, 95% CI 0.870 to 2.209;
p
= 0.169) or all-cause mortality (OR 1.13, 95% CI 0.75 to 1.71,
p
= 0.546). UF increases fluid removal and weight loss and reduces rehospitalization and the risk of worsening heart failure in congestive patients, suggesting ultrafiltration as a safe and effective treatment option for volume-overloaded heart failure patients.</description><identifier>ISSN: 1382-4147</identifier><identifier>EISSN: 1573-7322</identifier><identifier>DOI: 10.1007/s10741-020-10057-7</identifier><identifier>PMID: 33244656</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiology ; Clinical trials ; Congestive heart failure ; Diuretics ; Heart failure ; Medicine ; Medicine & Public Health ; Meta-analysis ; Patients ; Ultrafiltration</subject><ispartof>Heart failure reviews, 2021-05, Vol.26 (3), p.577-585</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9b27219a1ebb4c6bd42b83e53b74bd1d7657ce0d38de8f6682612d7b44623ca3</citedby><cites>FETCH-LOGICAL-c474t-9b27219a1ebb4c6bd42b83e53b74bd1d7657ce0d38de8f6682612d7b44623ca3</cites><orcidid>0000-0001-9565-0732</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10741-020-10057-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10741-020-10057-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33244656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wobbe, Bastian</creatorcontrib><creatorcontrib>Wagner, Juliane</creatorcontrib><creatorcontrib>Szabó, Dorottya Kata</creatorcontrib><creatorcontrib>Rostás, Ildikó</creatorcontrib><creatorcontrib>Farkas, Nelli</creatorcontrib><creatorcontrib>Garami, András</creatorcontrib><creatorcontrib>Balaskó, Márta</creatorcontrib><creatorcontrib>Hartmann, Petra</creatorcontrib><creatorcontrib>Solymár, Margit</creatorcontrib><creatorcontrib>Tenk, Judit</creatorcontrib><creatorcontrib>Ottóffy, Máté</creatorcontrib><creatorcontrib>Nagy, Arnold</creatorcontrib><creatorcontrib>Habon, Tamás</creatorcontrib><creatorcontrib>Hegyi, Péter</creatorcontrib><creatorcontrib>Czopf, László</creatorcontrib><title>Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis</title><title>Heart failure reviews</title><addtitle>Heart Fail Rev</addtitle><addtitle>Heart Fail Rev</addtitle><description>Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL;
p
< 0.001), weight loss (difference in means 1.592 kg, 95% CI 1.039 to 2.144 kg;
p
< 0.001) and lower incidences of worsening heart failure (OR 0.63, 95% CI 0.43 to 0.94,
p
= 0.022) and rehospitalization for heart failure (OR 0.54, 95% CI 0.36 to 0.82,
p
= 0.003) without a difference in renal impairment (OR 1.386, 95% CI 0.870 to 2.209;
p
= 0.169) or all-cause mortality (OR 1.13, 95% CI 0.75 to 1.71,
p
= 0.546). UF increases fluid removal and weight loss and reduces rehospitalization and the risk of worsening heart failure in congestive patients, suggesting ultrafiltration as a safe and effective treatment option for volume-overloaded heart failure patients.</description><subject>Cardiology</subject><subject>Clinical trials</subject><subject>Congestive heart failure</subject><subject>Diuretics</subject><subject>Heart failure</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>Ultrafiltration</subject><issn>1382-4147</issn><issn>1573-7322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UctuFDEQtBCIhMAPcECWuHAx8WvGMxyQUMRLipRLcrb86Mk68owX27PS_j1eNoTHIRfbra6q7nIh9JrR94xSdV4YVZIRyilpdaeIeoJOWacEUYLzp-0tBk4kk-oEvSjljlIqR0mfoxMhuJR915-ichNrNlM4nDWkBYeCLdQKGdeNWbAPa4YaXKsgm-0eTynjXYrrDCTtIMdkPHhs3FoBb8DkiicTYiPhbROEpZYP2OAZqiFmMXFfQnmJnk0mFnh1f5-h6y-fry--kcurr98vPl0SJ5WsZLRccTYaBtZK11svuR0EdMIqaT3zqu-UA-rF4GGY-n7gPeNe2eaMC2fEGfp4lN2udgbv2i7ZRL3NYTZ5r5MJ-t_OEjb6Nu30QLnkgjeBd_cCOf1YoVQ9h-IgRrNAWovm7QulGBSXDfr2P-hdWnPz21AdHRkde3oQ5EeUy6mUDNPDMozqQ6T6GKlukepfkWrVSG_-tvFA-Z1hA4gjoLTWcgv5z-xHZH8C_06u_A</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Wobbe, Bastian</creator><creator>Wagner, Juliane</creator><creator>Szabó, Dorottya Kata</creator><creator>Rostás, Ildikó</creator><creator>Farkas, Nelli</creator><creator>Garami, András</creator><creator>Balaskó, Márta</creator><creator>Hartmann, Petra</creator><creator>Solymár, Margit</creator><creator>Tenk, Judit</creator><creator>Ottóffy, Máté</creator><creator>Nagy, Arnold</creator><creator>Habon, Tamás</creator><creator>Hegyi, Péter</creator><creator>Czopf, László</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9565-0732</orcidid></search><sort><creationdate>20210501</creationdate><title>Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis</title><author>Wobbe, Bastian ; 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This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL;
p
< 0.001), weight loss (difference in means 1.592 kg, 95% CI 1.039 to 2.144 kg;
p
< 0.001) and lower incidences of worsening heart failure (OR 0.63, 95% CI 0.43 to 0.94,
p
= 0.022) and rehospitalization for heart failure (OR 0.54, 95% CI 0.36 to 0.82,
p
= 0.003) without a difference in renal impairment (OR 1.386, 95% CI 0.870 to 2.209;
p
= 0.169) or all-cause mortality (OR 1.13, 95% CI 0.75 to 1.71,
p
= 0.546). UF increases fluid removal and weight loss and reduces rehospitalization and the risk of worsening heart failure in congestive patients, suggesting ultrafiltration as a safe and effective treatment option for volume-overloaded heart failure patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33244656</pmid><doi>10.1007/s10741-020-10057-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9565-0732</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Cardiology Clinical trials Congestive heart failure Diuretics Heart failure Medicine Medicine & Public Health Meta-analysis Patients Ultrafiltration |
| title | Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis |
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