Serial Analysis of Circulating Tumor Cells in Metastatic Breast Cancer Receiving First-Line Chemotherapy

Abstract Background We examined the prognostic significance of circulating tumor cell (CTC) dynamics during treatment in metastatic breast cancer (MBC) patients receiving first-line chemotherapy. Methods Serial CTC data from 469 patients (2202 samples) were used to build a novel latent mixture model...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2021-04, Vol.113 (4), p.443-452
Hauptverfasser:	Magbanua, Mark Jesus M, Hendrix, Laura H, Hyslop, Terry, Barry, William T, Winer, Eric P, Hudis, Clifford, Toppmeyer, Deborah, Carey, Lisa Anne, Partridge, Ann H, Pierga, Jean-Yves, Fehm, Tanja, Vidal-Martínez, José, Mavroudis, Dimitrios, Garcia-Saenz, Jose A, Stebbing, Justin, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, Antelo, María Luisa, Mattos-Arruda, Leticia De, Generali, Daniele, Caldas, Carlos, Munzone, Elisabetta, Dirix, Luc, Delson, Amy L, Burstein, Harold J, Qadir, Misbah, Ma, Cynthia, Scott, Janet H, Bidard, François-Clément, Park, John W, Rugo, Hope S
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Chemotherapy Clinical trials Criteria Female Humans Metastases Metastasis Neoplastic Cells, Circulating - pathology Patients Prognosis Progression-Free Survival Proportional Hazards Models Reproducibility of Results Retrospective Studies Statistical analysis Statistical methods Survival Treatment Outcome Tumor cells Tumors
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