Overlapping Vitamin A Interventions with Provitamin A Carotenoids and Preformed Vitamin A Cause Excessive Liver Retinol Stores in Male Mongolian Gerbils

Vitamin A (VA) deficiency is a public health problem in some countries. Fortification, supplementation, and increased provitamin A consumption through biofortification are efficacious, but monitoring is needed due to risk of excessive VA intake when interventions overlap. Two studies in 28–36-d-old...

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Veröffentlicht in:	The Journal of nutrition 2020-11, Vol.150 (11), p.2912-2923
Hauptverfasser:	Sowa, Margaret, Mourao, Luciana, Sheftel, Jesse, Kaeppler, Mikayla, Simons, Gabrielle, Grahn, Michael, Davis, Christopher R, von Lintig, Johannes, Simon, Philipp W, Pixley, Kevin V, Tanumihardjo, Sherry A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animal models Animals Biofortification biofortified maize Carotene Carotenoids Carotenoids - administration & dosage Carotenoids - adverse effects Carotenoids - metabolism Carotenoids - pharmacokinetics Carrots Consumption Corn Cytochrome Cytochrome P450 Cytochromes P450 Daucus carota Depletion Diet Dietary intake Dietary supplements Dioxygenase Dose-Response Relationship, Drug Drug Interactions Editor's Choice Factorial design Food fortification Food intake fortification Gene expression Gerbillinae high carotene carrots High-performance liquid chromatography Homeobox Intestine Liquid chromatography Liver Liver - chemistry Liver - metabolism Male Nutrient deficiency Original s Oxygenase Public health Retinene Stores Vitamin A Vitamin A - administration & dosage Vitamin A - adverse effects Vitamin A - pharmacokinetics vitamin A status Vitamin deficiency Zea mays β-Carotene
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