Masking by hypokalemia—primary aldosteronism with undetectable aldosterone

Primary aldosteronism is the most common cause of secondary hypertension; however, the dynamic regulation of aldosterone by potassium is less well studied and current diagnostic recommendations are imprecise. We describe a young man who presented with resistant hypertension and severe hypokalemia. T...

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Veröffentlicht in:Clinical Kidney Journal 2021-04, Vol.14 (4), p.1269-1271
Hauptverfasser: Boyle, Rebecca A, Baker, Jessica E, Charu, Vivek, Rainey, William E, Bhalla, Vivek
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container_issue 4
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container_title Clinical Kidney Journal
container_volume 14
creator Boyle, Rebecca A
Baker, Jessica E
Charu, Vivek
Rainey, William E
Bhalla, Vivek
description Primary aldosteronism is the most common cause of secondary hypertension; however, the dynamic regulation of aldosterone by potassium is less well studied and current diagnostic recommendations are imprecise. We describe a young man who presented with resistant hypertension and severe hypokalemia. The workup initially revealed undetectable aldosterone despite acute potassium repletion. Chronic potassium supplementation eventually uncovered hyperaldosteronism. In situ genetic studies revealed a gain-of-function KCNJ5 mutation within an aldosterone-producing adenoma that was clinically responsive to changes in extracellular potassium. We highlight a unique presentation of Conn’s syndrome and discuss the implications for the molecular mechanisms of potassium regulation of aldosterone.
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subjects Aldosterone
Corticosteroids
Exceptional Cases
Hydrochlorothiazide
Hyperaldosteronism
Hypertension
Hypokalemia
Potassium channels
title Masking by hypokalemia—primary aldosteronism with undetectable aldosterone
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