Promotion of nerve regeneration by biodegradable nanofibrous scaffold following sciatic nerve transection in rats
Peripheral nerve injuries (PNIs) are one of the common causes of morbidity and disability worldwide. Autograft is considered the gold standard treatment for PNIs. However, due to the complications associated with autografts, other sources are considered as alternatives. Recently, electrospun nanofib...
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description | Peripheral nerve injuries (PNIs) are one of the common causes of morbidity and disability worldwide. Autograft is considered the gold standard treatment for PNIs. However, due to the complications associated with autografts, other sources are considered as alternatives. Recently, electrospun nanofibrous scaffolds have received wide attention in the field of tissue engineering. Exogenous tubular constructs with uniaxially aligned topographical cues to enhance the axonal re-growth are needed to bridge large nerve gaps between proximal and distal ends. Although several studies have used PLGA/PCL, but few studies have been conducted on developing a two-layer scaffold with aligned fibers properly orientated along the axis direction of the sciatic nerve to meet the physical properties required for suturing, transplantation, and nerve regeneration. In this study, we sought to design and develop PLGA-PCL-aligned nanofibers. Following the conventional examinations, we implanted the scaffolds into 7-mm sciatic nerve gaps in a rat model of nerve injury. Our in vivo evaluations did not show any adverse effects, and after eight weeks, an acceptable improvement was noted in the electrophysiological, functional, and histological analyses. Thus, it can be concluded that nanofiber scaffolds can be used as a reliable approach for repairing PNIs. However, further research is warranted. |
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Autograft is considered the gold standard treatment for PNIs. However, due to the complications associated with autografts, other sources are considered as alternatives. Recently, electrospun nanofibrous scaffolds have received wide attention in the field of tissue engineering. Exogenous tubular constructs with uniaxially aligned topographical cues to enhance the axonal re-growth are needed to bridge large nerve gaps between proximal and distal ends. Although several studies have used PLGA/PCL, but few studies have been conducted on developing a two-layer scaffold with aligned fibers properly orientated along the axis direction of the sciatic nerve to meet the physical properties required for suturing, transplantation, and nerve regeneration. In this study, we sought to design and develop PLGA-PCL-aligned nanofibers. Following the conventional examinations, we implanted the scaffolds into 7-mm sciatic nerve gaps in a rat model of nerve injury. Our in vivo evaluations did not show any adverse effects, and after eight weeks, an acceptable improvement was noted in the electrophysiological, functional, and histological analyses. Thus, it can be concluded that nanofiber scaffolds can be used as a reliable approach for repairing PNIs. However, further research is warranted.</description><identifier>ISSN: 2194-0509</identifier><identifier>EISSN: 2194-0517</identifier><identifier>DOI: 10.1007/s40204-021-00151-w</identifier><identifier>PMID: 33683651</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autografts ; Biodegradability ; Biomaterials ; Chemistry and Materials Science ; Materials Science ; Morbidity ; Nanofibers ; Original Research ; Peripheral nerves ; Physical properties ; Polylactide-co-glycolide ; Regeneration ; Scaffolds ; Sciatic nerve ; Surgical implants ; Tissue engineering ; Transplantation</subject><ispartof>Progress in Biomaterials, 2021-03, Vol.10 (1), p.53-64</ispartof><rights>Islamic Azad University 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Islamic Azad University 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-6abd8e47e5e05ff9f9d4786fe7ed5a8d8f3e7b231bdab9361956d3f0822ee79f3</citedby><cites>FETCH-LOGICAL-c578t-6abd8e47e5e05ff9f9d4786fe7ed5a8d8f3e7b231bdab9361956d3f0822ee79f3</cites><orcidid>0000-0002-2388-481X ; 0000-0001-8166-0067 ; 0000-0003-4661-5054 ; 0000-0002-4021-9627</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021629/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021629/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33683651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moharrami Kasmaie, Farshad</creatorcontrib><creatorcontrib>Zamani, Fatemeh</creatorcontrib><creatorcontrib>Sayad-Fathi, Sara</creatorcontrib><creatorcontrib>Zaminy, Arash</creatorcontrib><title>Promotion of nerve regeneration by biodegradable nanofibrous scaffold following sciatic nerve transection in rats</title><title>Progress in Biomaterials</title><addtitle>Prog Biomater</addtitle><addtitle>Prog Biomater</addtitle><description>Peripheral nerve injuries (PNIs) are one of the common causes of morbidity and disability worldwide. Autograft is considered the gold standard treatment for PNIs. However, due to the complications associated with autografts, other sources are considered as alternatives. Recently, electrospun nanofibrous scaffolds have received wide attention in the field of tissue engineering. Exogenous tubular constructs with uniaxially aligned topographical cues to enhance the axonal re-growth are needed to bridge large nerve gaps between proximal and distal ends. Although several studies have used PLGA/PCL, but few studies have been conducted on developing a two-layer scaffold with aligned fibers properly orientated along the axis direction of the sciatic nerve to meet the physical properties required for suturing, transplantation, and nerve regeneration. In this study, we sought to design and develop PLGA-PCL-aligned nanofibers. Following the conventional examinations, we implanted the scaffolds into 7-mm sciatic nerve gaps in a rat model of nerve injury. Our in vivo evaluations did not show any adverse effects, and after eight weeks, an acceptable improvement was noted in the electrophysiological, functional, and histological analyses. Thus, it can be concluded that nanofiber scaffolds can be used as a reliable approach for repairing PNIs. However, further research is warranted.</description><subject>Autografts</subject><subject>Biodegradability</subject><subject>Biomaterials</subject><subject>Chemistry and Materials Science</subject><subject>Materials Science</subject><subject>Morbidity</subject><subject>Nanofibers</subject><subject>Original Research</subject><subject>Peripheral nerves</subject><subject>Physical properties</subject><subject>Polylactide-co-glycolide</subject><subject>Regeneration</subject><subject>Scaffolds</subject><subject>Sciatic nerve</subject><subject>Surgical implants</subject><subject>Tissue engineering</subject><subject>Transplantation</subject><issn>2194-0509</issn><issn>2194-0517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UsluFDEQbSEQiUJ-gANqiQuXDl7a2wUpitikSHCAs-VulxtH3XZiz2SUv6cyPQzLAVuyS-X3nl_Z1TQvKbmghKi3tSeM9B1htCOECtrtnjSnjBpMCaqeHmNiTprzWm8IDtUTTtXz5oRzqbkU9LS5-1rykjcxpzaHNkG5h7bABBi5fXZ4aIeYPUzFeTfM0CaXcohDydva1tGFkGff4jLnXUwTpiISx4PUprhUYdwrxdSiZn3RPAturnB-2M-a7x_ef7v61F1_-fj56vK6G4XSm066wWvoFQggIgQTjO-VlgEUeOG014GDGhinA9oyXFIjpOeBaMYAlAn8rHm36t5uhwX8CAnNzPa2xMWVB5tdtH-fpPjDTvneanxTyQwKvDkIlHy3hbqxS6wjzLNLgMVb1htDiJQ9Q-jrf6A3eVsSlmeZIFpR2RONqIsVNbkZbEwh470jTg9LHHOCEDF_KYUSnCjxKMtWwlhyrQXC0T0l9rEL7NoFFh3bfRfYHZJe_Vn3kfLrzxHAV0DFozRB-W32P7I_Ad65wOc</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Moharrami Kasmaie, Farshad</creator><creator>Zamani, Fatemeh</creator><creator>Sayad-Fathi, Sara</creator><creator>Zaminy, Arash</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2388-481X</orcidid><orcidid>https://orcid.org/0000-0001-8166-0067</orcidid><orcidid>https://orcid.org/0000-0003-4661-5054</orcidid><orcidid>https://orcid.org/0000-0002-4021-9627</orcidid></search><sort><creationdate>20210301</creationdate><title>Promotion of nerve regeneration by biodegradable nanofibrous scaffold following sciatic nerve transection in rats</title><author>Moharrami Kasmaie, Farshad ; Zamani, Fatemeh ; Sayad-Fathi, Sara ; Zaminy, Arash</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-6abd8e47e5e05ff9f9d4786fe7ed5a8d8f3e7b231bdab9361956d3f0822ee79f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autografts</topic><topic>Biodegradability</topic><topic>Biomaterials</topic><topic>Chemistry and Materials Science</topic><topic>Materials Science</topic><topic>Morbidity</topic><topic>Nanofibers</topic><topic>Original Research</topic><topic>Peripheral nerves</topic><topic>Physical properties</topic><topic>Polylactide-co-glycolide</topic><topic>Regeneration</topic><topic>Scaffolds</topic><topic>Sciatic nerve</topic><topic>Surgical implants</topic><topic>Tissue engineering</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moharrami Kasmaie, Farshad</creatorcontrib><creatorcontrib>Zamani, Fatemeh</creatorcontrib><creatorcontrib>Sayad-Fathi, Sara</creatorcontrib><creatorcontrib>Zaminy, Arash</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Progress in Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moharrami Kasmaie, Farshad</au><au>Zamani, Fatemeh</au><au>Sayad-Fathi, Sara</au><au>Zaminy, Arash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Promotion of nerve regeneration by biodegradable nanofibrous scaffold following sciatic nerve transection in rats</atitle><jtitle>Progress in Biomaterials</jtitle><stitle>Prog Biomater</stitle><addtitle>Prog Biomater</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>10</volume><issue>1</issue><spage>53</spage><epage>64</epage><pages>53-64</pages><issn>2194-0509</issn><eissn>2194-0517</eissn><abstract>Peripheral nerve injuries (PNIs) are one of the common causes of morbidity and disability worldwide. Autograft is considered the gold standard treatment for PNIs. However, due to the complications associated with autografts, other sources are considered as alternatives. Recently, electrospun nanofibrous scaffolds have received wide attention in the field of tissue engineering. Exogenous tubular constructs with uniaxially aligned topographical cues to enhance the axonal re-growth are needed to bridge large nerve gaps between proximal and distal ends. Although several studies have used PLGA/PCL, but few studies have been conducted on developing a two-layer scaffold with aligned fibers properly orientated along the axis direction of the sciatic nerve to meet the physical properties required for suturing, transplantation, and nerve regeneration. In this study, we sought to design and develop PLGA-PCL-aligned nanofibers. Following the conventional examinations, we implanted the scaffolds into 7-mm sciatic nerve gaps in a rat model of nerve injury. Our in vivo evaluations did not show any adverse effects, and after eight weeks, an acceptable improvement was noted in the electrophysiological, functional, and histological analyses. Thus, it can be concluded that nanofiber scaffolds can be used as a reliable approach for repairing PNIs. However, further research is warranted.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33683651</pmid><doi>10.1007/s40204-021-00151-w</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2388-481X</orcidid><orcidid>https://orcid.org/0000-0001-8166-0067</orcidid><orcidid>https://orcid.org/0000-0003-4661-5054</orcidid><orcidid>https://orcid.org/0000-0002-4021-9627</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Autografts Biodegradability Biomaterials Chemistry and Materials Science Materials Science Morbidity Nanofibers Original Research Peripheral nerves Physical properties Polylactide-co-glycolide Regeneration Scaffolds Sciatic nerve Surgical implants Tissue engineering Transplantation |
title | Promotion of nerve regeneration by biodegradable nanofibrous scaffold following sciatic nerve transection in rats |
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