Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway
Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small mo...
Gespeichert in:
| Veröffentlicht in: | Food Science & Nutrition 2021-04, Vol.9 (4), p.1833-1841 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1841 |
|---|---|
| container_issue | 4 |
| container_start_page | 1833 |
| container_title | Food Science & Nutrition |
| container_volume | 9 |
| creator | Wei, Lian‐Hui Dong, Yan Sun, Yu‐Feng Mei, Xue‐Song Ma, Xue‐Song Shi, Jie Yang, Qing‐li Ji, Yan‐Ru Zhang, Zheng‐Hai Sun, Hu‐Nan Sun, Xing‐Rong Song, Shu‐Min |
| description | Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells. We demonstrate that HP treatment increased apoptosis, reduced cell viability, and reduced cell migration in Hep3B human liver cancer cells without affecting the normal liver cell line L02. We correlate these phenotypes with increased cellular ROS levels, upregulation of cleaved caspase 3 and Bad, and downregulation of antiapoptotic Bcl‐2. HP treatment led to increased Akt and GSK‐3β phosphorylation, with subsequent downregulation of β‐catenin, suggesting β‐catenin signaling modulation as a critical mechanism by which HP exhibits anticancer properties. Our findings suggest HP are of potential therapeutic interest for liver cancer treatment.
Anti‐cancer property of new hemp protein hydrolysates on human liver cancers |
| doi_str_mv | 10.1002/fsn3.1976 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8020916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A708359207</galeid><sourcerecordid>A708359207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5106-ff5449361adc827e886cf82ce77d9bc2946c6cb35217ac3946ff4345bee72fe53</originalsourceid><addsrcrecordid>eNp1ks1u1DAQxyMEolXpgRdAlrjAYXf9EcfJBWlb0RZRAVLhbHmdcdYlsVM7abUSBx6BZ-mD9CF4Ehx2qQoS9sH2zG_-47Eny54TPCcY04WJjs1JJYpH2T7FeTkTRIjHD_Z72WGMlziNKicFpU-zPcbKnJSY7mfflm6wWjkNAfXB9xCGDfIGnUHXoyPrlR7sNaBP0A-2hoisS66eHaE2mQPaRWpo24iGdfBjs0bLr8Pi9OI9u7td3N3-_P5DqwFcCoy2caq1rkG9GtY3avMse2JUG-Fwtx5kX07efj4-m51_PH13vDyfaU5wMTOG53nFCqJqXVIBZVloU1INQtTVStMqL3ShV4xTIpRm6WhMznK-AhDUAGcH2Zutbj-uOqg1uCGoVvbBdipspFdW_u1xdi0bfy3TE-GKFEng1U4g-KsR4iA7G6eilQM_Rkk5IWXFRSES-vIf9NKPIdU9UbjkvGKcJWq-pRrVgrTO-JRXp1lDZ7V3YGyyLwUuGa8onmRfbwN08DEGMPe3J1hOfSCnPpBTHyT2xcNy78k_v56AxRa4SVk2_1eSJxcf2G_JX9QQv6w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2508559353</pqid></control><display><type>article</type><title>Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway</title><source>Wiley Online Library Open Access</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Wei, Lian‐Hui ; Dong, Yan ; Sun, Yu‐Feng ; Mei, Xue‐Song ; Ma, Xue‐Song ; Shi, Jie ; Yang, Qing‐li ; Ji, Yan‐Ru ; Zhang, Zheng‐Hai ; Sun, Hu‐Nan ; Sun, Xing‐Rong ; Song, Shu‐Min</creator><creatorcontrib>Wei, Lian‐Hui ; Dong, Yan ; Sun, Yu‐Feng ; Mei, Xue‐Song ; Ma, Xue‐Song ; Shi, Jie ; Yang, Qing‐li ; Ji, Yan‐Ru ; Zhang, Zheng‐Hai ; Sun, Hu‐Nan ; Sun, Xing‐Rong ; Song, Shu‐Min</creatorcontrib><description>Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells. We demonstrate that HP treatment increased apoptosis, reduced cell viability, and reduced cell migration in Hep3B human liver cancer cells without affecting the normal liver cell line L02. We correlate these phenotypes with increased cellular ROS levels, upregulation of cleaved caspase 3 and Bad, and downregulation of antiapoptotic Bcl‐2. HP treatment led to increased Akt and GSK‐3β phosphorylation, with subsequent downregulation of β‐catenin, suggesting β‐catenin signaling modulation as a critical mechanism by which HP exhibits anticancer properties. Our findings suggest HP are of potential therapeutic interest for liver cancer treatment.
Anti‐cancer property of new hemp protein hydrolysates on human liver cancers</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.1976</identifier><identifier>PMID: 33841802</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>AKT protein ; Amino acids ; anticancer ; Anticancer properties ; Apoptosis ; Biological activity ; Cancer ; Cancer cells ; Care and treatment ; Caspase-3 ; Catenin ; Cell culture ; Cell cycle ; Cell migration ; Cell viability ; GSK3β signaling ; Health aspects ; Health insurance ; Hemp ; hemp seed (Cannabis sativa L.) ; Hepatocytes ; Hydrolysates ; Hydrolysis ; Liver ; Liver cancer ; Membranes ; Microscopy ; Molecular weight ; Original Research ; Peptides ; Phenotypes ; Phosphorylation ; Protein hydrolysates ; Proteins ; ROS ; Seeds ; Signal transduction ; Signaling ; Variance analysis ; Wound healing</subject><ispartof>Food Science & Nutrition, 2021-04, Vol.9 (4), p.1833-1841</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC</rights><rights>2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5106-ff5449361adc827e886cf82ce77d9bc2946c6cb35217ac3946ff4345bee72fe53</citedby><cites>FETCH-LOGICAL-c5106-ff5449361adc827e886cf82ce77d9bc2946c6cb35217ac3946ff4345bee72fe53</cites><orcidid>0000-0002-7136-0172</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020916/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020916/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33841802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Lian‐Hui</creatorcontrib><creatorcontrib>Dong, Yan</creatorcontrib><creatorcontrib>Sun, Yu‐Feng</creatorcontrib><creatorcontrib>Mei, Xue‐Song</creatorcontrib><creatorcontrib>Ma, Xue‐Song</creatorcontrib><creatorcontrib>Shi, Jie</creatorcontrib><creatorcontrib>Yang, Qing‐li</creatorcontrib><creatorcontrib>Ji, Yan‐Ru</creatorcontrib><creatorcontrib>Zhang, Zheng‐Hai</creatorcontrib><creatorcontrib>Sun, Hu‐Nan</creatorcontrib><creatorcontrib>Sun, Xing‐Rong</creatorcontrib><creatorcontrib>Song, Shu‐Min</creatorcontrib><title>Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells. We demonstrate that HP treatment increased apoptosis, reduced cell viability, and reduced cell migration in Hep3B human liver cancer cells without affecting the normal liver cell line L02. We correlate these phenotypes with increased cellular ROS levels, upregulation of cleaved caspase 3 and Bad, and downregulation of antiapoptotic Bcl‐2. HP treatment led to increased Akt and GSK‐3β phosphorylation, with subsequent downregulation of β‐catenin, suggesting β‐catenin signaling modulation as a critical mechanism by which HP exhibits anticancer properties. Our findings suggest HP are of potential therapeutic interest for liver cancer treatment.
Anti‐cancer property of new hemp protein hydrolysates on human liver cancers</description><subject>AKT protein</subject><subject>Amino acids</subject><subject>anticancer</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Biological activity</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Care and treatment</subject><subject>Caspase-3</subject><subject>Catenin</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell migration</subject><subject>Cell viability</subject><subject>GSK3β signaling</subject><subject>Health aspects</subject><subject>Health insurance</subject><subject>Hemp</subject><subject>hemp seed (Cannabis sativa L.)</subject><subject>Hepatocytes</subject><subject>Hydrolysates</subject><subject>Hydrolysis</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Membranes</subject><subject>Microscopy</subject><subject>Molecular weight</subject><subject>Original Research</subject><subject>Peptides</subject><subject>Phenotypes</subject><subject>Phosphorylation</subject><subject>Protein hydrolysates</subject><subject>Proteins</subject><subject>ROS</subject><subject>Seeds</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Variance analysis</subject><subject>Wound healing</subject><issn>2048-7177</issn><issn>2048-7177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ks1u1DAQxyMEolXpgRdAlrjAYXf9EcfJBWlb0RZRAVLhbHmdcdYlsVM7abUSBx6BZ-mD9CF4Ehx2qQoS9sH2zG_-47Eny54TPCcY04WJjs1JJYpH2T7FeTkTRIjHD_Z72WGMlziNKicFpU-zPcbKnJSY7mfflm6wWjkNAfXB9xCGDfIGnUHXoyPrlR7sNaBP0A-2hoisS66eHaE2mQPaRWpo24iGdfBjs0bLr8Pi9OI9u7td3N3-_P5DqwFcCoy2caq1rkG9GtY3avMse2JUG-Fwtx5kX07efj4-m51_PH13vDyfaU5wMTOG53nFCqJqXVIBZVloU1INQtTVStMqL3ShV4xTIpRm6WhMznK-AhDUAGcH2Zutbj-uOqg1uCGoVvbBdipspFdW_u1xdi0bfy3TE-GKFEng1U4g-KsR4iA7G6eilQM_Rkk5IWXFRSES-vIf9NKPIdU9UbjkvGKcJWq-pRrVgrTO-JRXp1lDZ7V3YGyyLwUuGa8onmRfbwN08DEGMPe3J1hOfSCnPpBTHyT2xcNy78k_v56AxRa4SVk2_1eSJxcf2G_JX9QQv6w</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Wei, Lian‐Hui</creator><creator>Dong, Yan</creator><creator>Sun, Yu‐Feng</creator><creator>Mei, Xue‐Song</creator><creator>Ma, Xue‐Song</creator><creator>Shi, Jie</creator><creator>Yang, Qing‐li</creator><creator>Ji, Yan‐Ru</creator><creator>Zhang, Zheng‐Hai</creator><creator>Sun, Hu‐Nan</creator><creator>Sun, Xing‐Rong</creator><creator>Song, Shu‐Min</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7136-0172</orcidid></search><sort><creationdate>202104</creationdate><title>Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway</title><author>Wei, Lian‐Hui ; Dong, Yan ; Sun, Yu‐Feng ; Mei, Xue‐Song ; Ma, Xue‐Song ; Shi, Jie ; Yang, Qing‐li ; Ji, Yan‐Ru ; Zhang, Zheng‐Hai ; Sun, Hu‐Nan ; Sun, Xing‐Rong ; Song, Shu‐Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5106-ff5449361adc827e886cf82ce77d9bc2946c6cb35217ac3946ff4345bee72fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>AKT protein</topic><topic>Amino acids</topic><topic>anticancer</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Biological activity</topic><topic>Cancer</topic><topic>Cancer cells</topic><topic>Care and treatment</topic><topic>Caspase-3</topic><topic>Catenin</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Cell migration</topic><topic>Cell viability</topic><topic>GSK3β signaling</topic><topic>Health aspects</topic><topic>Health insurance</topic><topic>Hemp</topic><topic>hemp seed (Cannabis sativa L.)</topic><topic>Hepatocytes</topic><topic>Hydrolysates</topic><topic>Hydrolysis</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Membranes</topic><topic>Microscopy</topic><topic>Molecular weight</topic><topic>Original Research</topic><topic>Peptides</topic><topic>Phenotypes</topic><topic>Phosphorylation</topic><topic>Protein hydrolysates</topic><topic>Proteins</topic><topic>ROS</topic><topic>Seeds</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Variance analysis</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Lian‐Hui</creatorcontrib><creatorcontrib>Dong, Yan</creatorcontrib><creatorcontrib>Sun, Yu‐Feng</creatorcontrib><creatorcontrib>Mei, Xue‐Song</creatorcontrib><creatorcontrib>Ma, Xue‐Song</creatorcontrib><creatorcontrib>Shi, Jie</creatorcontrib><creatorcontrib>Yang, Qing‐li</creatorcontrib><creatorcontrib>Ji, Yan‐Ru</creatorcontrib><creatorcontrib>Zhang, Zheng‐Hai</creatorcontrib><creatorcontrib>Sun, Hu‐Nan</creatorcontrib><creatorcontrib>Sun, Xing‐Rong</creatorcontrib><creatorcontrib>Song, Shu‐Min</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Food Science & Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Lian‐Hui</au><au>Dong, Yan</au><au>Sun, Yu‐Feng</au><au>Mei, Xue‐Song</au><au>Ma, Xue‐Song</au><au>Shi, Jie</au><au>Yang, Qing‐li</au><au>Ji, Yan‐Ru</au><au>Zhang, Zheng‐Hai</au><au>Sun, Hu‐Nan</au><au>Sun, Xing‐Rong</au><au>Song, Shu‐Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2021-04</date><risdate>2021</risdate><volume>9</volume><issue>4</issue><spage>1833</spage><epage>1841</epage><pages>1833-1841</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells. We demonstrate that HP treatment increased apoptosis, reduced cell viability, and reduced cell migration in Hep3B human liver cancer cells without affecting the normal liver cell line L02. We correlate these phenotypes with increased cellular ROS levels, upregulation of cleaved caspase 3 and Bad, and downregulation of antiapoptotic Bcl‐2. HP treatment led to increased Akt and GSK‐3β phosphorylation, with subsequent downregulation of β‐catenin, suggesting β‐catenin signaling modulation as a critical mechanism by which HP exhibits anticancer properties. Our findings suggest HP are of potential therapeutic interest for liver cancer treatment.
Anti‐cancer property of new hemp protein hydrolysates on human liver cancers</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>33841802</pmid><doi>10.1002/fsn3.1976</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0002-7136-0172</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2048-7177 |
| ispartof | Food Science & Nutrition, 2021-04, Vol.9 (4), p.1833-1841 |
| issn | 2048-7177 2048-7177 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8020916 |
| source | Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | AKT protein Amino acids anticancer Anticancer properties Apoptosis Biological activity Cancer Cancer cells Care and treatment Caspase-3 Catenin Cell culture Cell cycle Cell migration Cell viability GSK3β signaling Health aspects Health insurance Hemp hemp seed (Cannabis sativa L.) Hepatocytes Hydrolysates Hydrolysis Liver Liver cancer Membranes Microscopy Molecular weight Original Research Peptides Phenotypes Phosphorylation Protein hydrolysates Proteins ROS Seeds Signal transduction Signaling Variance analysis Wound healing |
| title | Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T05%3A05%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anticancer%20property%20of%20Hemp%20Bioactive%20Peptides%20in%20Hep3B%20liver%20cancer%20cells%20through%20Akt/GSK3%CE%B2/%CE%B2%E2%80%90catenin%20signaling%20pathway&rft.jtitle=Food%20Science%20&%20Nutrition&rft.au=Wei,%20Lian%E2%80%90Hui&rft.date=2021-04&rft.volume=9&rft.issue=4&rft.spage=1833&rft.epage=1841&rft.pages=1833-1841&rft.issn=2048-7177&rft.eissn=2048-7177&rft_id=info:doi/10.1002/fsn3.1976&rft_dat=%3Cgale_pubme%3EA708359207%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2508559353&rft_id=info:pmid/33841802&rft_galeid=A708359207&rfr_iscdi=true |