Cingulo-opercular control network and disused motor circuits joined in standby mode
Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2021-03, Vol.118 (13), p.1-10 |
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| creator | Newbold, Dillan J. Gordon, Evan M. Laumann, Timothy O. Seider, Nicole A. Montez, David F. Gross, Sarah J. Zheng, Annie Nielsen, Ashley N. Hoyt, Catherine R. Hampton, Jacqueline M. Ortega, Mario Adeyemo, Babatunde Miller, Derek B. Van, Andrew N. Marek, Scott Schlaggar, Bradley L. Carter, Alexandre R. Kay, Benjamin P. Greene, Deanna J. Raichle, Marcus E. Petersen, Steven E. Snyder, Abraham Z. Dosenbach, Nico U. F. |
| description | Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions. |
| doi_str_mv | 10.1073/pnas.2019128118 |
| format | Article |
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F.</creatorcontrib><title>Cingulo-opercular control network and disused motor circuits joined in standby mode</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.</description><subject>Adult</subject><subject>Biological Sciences</subject><subject>Brain Mapping</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Gyrus Cinguli - cytology</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Gyrus Cinguli - physiology</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Nerve Net - physiology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Rest - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1PGzEQxS1U1KTQc0-t9tjLwviLtS9IVVRoJSQOwNlyvOPgsLGDvUvFf49RaFpOI8385s3TPEK-UDih0PHTbbTlhAHVlClK1QGZU9C0PRMaPpA5AOtaJZiYkU-lrAFASwUfyYzzTnKhxJzcLEJcTUNq0xazmwabG5fimNPQRBz_pPzQ2Ng3fShTwb7ZpDFVIlQ0jKVZpxBrN8SmjBVbPlegx2Ny6O1Q8PNbPSJ3Fz9vF7_aq-vL34sfV60TVI6t7JjzoIWjDq1yElD3rGMomEbBtRNL7bkTnllBvV5K7DUDhai875i3PT8i5zvd7bTcYO-w-raD2eawsfnZJBvM-0kM92aVnowCBp2mVeD7m0BOjxOW0WxCcTgMNmKaimESBJeUMlbR0x3qciolo9-foWBeozCvUZh_UdSNb_-72_N_f1-BrztgXepT93PWAdeKSv4Cf6aRxA</recordid><startdate>20210330</startdate><enddate>20210330</enddate><creator>Newbold, Dillan J.</creator><creator>Gordon, Evan M.</creator><creator>Laumann, Timothy O.</creator><creator>Seider, Nicole A.</creator><creator>Montez, David F.</creator><creator>Gross, Sarah J.</creator><creator>Zheng, Annie</creator><creator>Nielsen, Ashley N.</creator><creator>Hoyt, Catherine R.</creator><creator>Hampton, Jacqueline M.</creator><creator>Ortega, Mario</creator><creator>Adeyemo, Babatunde</creator><creator>Miller, Derek B.</creator><creator>Van, Andrew N.</creator><creator>Marek, Scott</creator><creator>Schlaggar, Bradley L.</creator><creator>Carter, Alexandre R.</creator><creator>Kay, Benjamin P.</creator><creator>Greene, Deanna J.</creator><creator>Raichle, Marcus E.</creator><creator>Petersen, Steven E.</creator><creator>Snyder, Abraham Z.</creator><creator>Dosenbach, Nico U. 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Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. 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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adult Biological Sciences Brain Mapping Executive Function - physiology Female Gyrus Cinguli - cytology Gyrus Cinguli - diagnostic imaging Gyrus Cinguli - physiology Healthy Volunteers Humans Magnetic Resonance Imaging Male Nerve Net - physiology Neuronal Plasticity - physiology Rest - physiology |
| title | Cingulo-opercular control network and disused motor circuits joined in standby mode |
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