Trained immunity, tolerance, priming and differentiation: distinct immunological processes
The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for ad...
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| Veröffentlicht in: | Nature immunology 2021-01, Vol.22 (1), p.2-6 |
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| creator | Divangahi, Maziar Aaby, Peter Khader, Shabaana Abdul Barreiro, Luis B. Bekkering, Siroon Chavakis, Triantafyllos van Crevel, Reinout Curtis, Nigel DiNardo, Andrew R. Dominguez-Andres, Jorge Duivenvoorden, Raphael Fanucchi, Stephanie Fayad, Zahi Fuchs, Elaine Hamon, Melanie Jeffrey, Kate L. Khan, Nargis Joosten, Leo A. B. Kaufmann, Eva Latz, Eicke Matarese, Giuseppe van der Meer, Jos W. M. Mhlanga, Musa Moorlag, Simone J. C. F. M. Mulder, Willem J. M. Naik, Shruti Novakovic, Boris O’Neill, Luke Ochando, Jordi Ozato, Keiko Riksen, Niels P. Sauerwein, Robert Sherwood, Edward R. Schlitzer, Andreas Schultze, Joachim L. Sieweke, Michael H. Benn, Christine Stabell Stunnenberg, Henk Sun, Joseph van de Veerdonk, Frank L. Weis, Sebastian Williams, David L. Xavier, Ramnik Netea, Mihai G. |
| description | The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity. |
| doi_str_mv | 10.1038/s41590-020-00845-6 |
| format | Article |
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M. ; Naik, Shruti ; Novakovic, Boris ; O’Neill, Luke ; Ochando, Jordi ; Ozato, Keiko ; Riksen, Niels P. ; Sauerwein, Robert ; Sherwood, Edward R. ; Schlitzer, Andreas ; Schultze, Joachim L. ; Sieweke, Michael H. ; Benn, Christine Stabell ; Stunnenberg, Henk ; Sun, Joseph ; van de Veerdonk, Frank L. ; Weis, Sebastian ; Williams, David L. ; Xavier, Ramnik ; Netea, Mihai G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c679t-8d312efd3b117b74eb3cddf91f073b643d0a4b9f015a5187b6f45965c2f5cb4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/250</topic><topic>692/420</topic><topic>Adaptive Immunity</topic><topic>Adaptive Immunity - immunology</topic><topic>Animals</topic><topic>BCG Vaccine</topic><topic>BCG Vaccine - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone marrow</topic><topic>Cell Differentiation</topic><topic>Comment</topic><topic>Cytokines</topic><topic>Epigenetics</topic><topic>Genes</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immune Tolerance</topic><topic>Immune Tolerance - immunology</topic><topic>Immunity</topic><topic>Immunity, Innate</topic><topic>Immunity, Innate - immunology</topic><topic>Immunologic Memory</topic><topic>Immunologic Memory - immunology</topic><topic>Immunological tolerance</topic><topic>Immunology</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Life Sciences</topic><topic>Observations</topic><topic>Pathogens</topic><topic>Physiological research</topic><topic>Sepsis</topic><topic>Tuberculosis</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Divangahi, Maziar</creatorcontrib><creatorcontrib>Aaby, Peter</creatorcontrib><creatorcontrib>Khader, Shabaana Abdul</creatorcontrib><creatorcontrib>Barreiro, Luis B.</creatorcontrib><creatorcontrib>Bekkering, Siroon</creatorcontrib><creatorcontrib>Chavakis, Triantafyllos</creatorcontrib><creatorcontrib>van Crevel, Reinout</creatorcontrib><creatorcontrib>Curtis, Nigel</creatorcontrib><creatorcontrib>DiNardo, Andrew R.</creatorcontrib><creatorcontrib>Dominguez-Andres, Jorge</creatorcontrib><creatorcontrib>Duivenvoorden, Raphael</creatorcontrib><creatorcontrib>Fanucchi, Stephanie</creatorcontrib><creatorcontrib>Fayad, Zahi</creatorcontrib><creatorcontrib>Fuchs, Elaine</creatorcontrib><creatorcontrib>Hamon, Melanie</creatorcontrib><creatorcontrib>Jeffrey, Kate L.</creatorcontrib><creatorcontrib>Khan, Nargis</creatorcontrib><creatorcontrib>Joosten, Leo A. B.</creatorcontrib><creatorcontrib>Kaufmann, Eva</creatorcontrib><creatorcontrib>Latz, Eicke</creatorcontrib><creatorcontrib>Matarese, Giuseppe</creatorcontrib><creatorcontrib>van der Meer, Jos W. M.</creatorcontrib><creatorcontrib>Mhlanga, Musa</creatorcontrib><creatorcontrib>Moorlag, Simone J. C. F. M.</creatorcontrib><creatorcontrib>Mulder, Willem J. M.</creatorcontrib><creatorcontrib>Naik, Shruti</creatorcontrib><creatorcontrib>Novakovic, Boris</creatorcontrib><creatorcontrib>O’Neill, Luke</creatorcontrib><creatorcontrib>Ochando, Jordi</creatorcontrib><creatorcontrib>Ozato, Keiko</creatorcontrib><creatorcontrib>Riksen, Niels P.</creatorcontrib><creatorcontrib>Sauerwein, Robert</creatorcontrib><creatorcontrib>Sherwood, Edward R.</creatorcontrib><creatorcontrib>Schlitzer, Andreas</creatorcontrib><creatorcontrib>Schultze, Joachim L.</creatorcontrib><creatorcontrib>Sieweke, Michael H.</creatorcontrib><creatorcontrib>Benn, Christine Stabell</creatorcontrib><creatorcontrib>Stunnenberg, Henk</creatorcontrib><creatorcontrib>Sun, Joseph</creatorcontrib><creatorcontrib>van de Veerdonk, Frank L.</creatorcontrib><creatorcontrib>Weis, Sebastian</creatorcontrib><creatorcontrib>Williams, David L.</creatorcontrib><creatorcontrib>Xavier, Ramnik</creatorcontrib><creatorcontrib>Netea, Mihai G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Divangahi, Maziar</au><au>Aaby, Peter</au><au>Khader, Shabaana Abdul</au><au>Barreiro, Luis B.</au><au>Bekkering, Siroon</au><au>Chavakis, Triantafyllos</au><au>van Crevel, Reinout</au><au>Curtis, Nigel</au><au>DiNardo, Andrew R.</au><au>Dominguez-Andres, Jorge</au><au>Duivenvoorden, Raphael</au><au>Fanucchi, Stephanie</au><au>Fayad, Zahi</au><au>Fuchs, Elaine</au><au>Hamon, Melanie</au><au>Jeffrey, Kate L.</au><au>Khan, Nargis</au><au>Joosten, Leo A. B.</au><au>Kaufmann, Eva</au><au>Latz, Eicke</au><au>Matarese, Giuseppe</au><au>van der Meer, Jos W. M.</au><au>Mhlanga, Musa</au><au>Moorlag, Simone J. C. F. M.</au><au>Mulder, Willem J. M.</au><au>Naik, Shruti</au><au>Novakovic, Boris</au><au>O’Neill, Luke</au><au>Ochando, Jordi</au><au>Ozato, Keiko</au><au>Riksen, Niels P.</au><au>Sauerwein, Robert</au><au>Sherwood, Edward R.</au><au>Schlitzer, Andreas</au><au>Schultze, Joachim L.</au><au>Sieweke, Michael H.</au><au>Benn, Christine Stabell</au><au>Stunnenberg, Henk</au><au>Sun, Joseph</au><au>van de Veerdonk, Frank L.</au><au>Weis, Sebastian</au><au>Williams, David L.</au><au>Xavier, Ramnik</au><au>Netea, Mihai G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trained immunity, tolerance, priming and differentiation: distinct immunological processes</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>22</volume><issue>1</issue><spage>2</spage><epage>6</epage><pages>2-6</pages><issn>1529-2908</issn><issn>1529-2916</issn><eissn>1529-2916</eissn><abstract>The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33293712</pmid><doi>10.1038/s41590-020-00845-6</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9197-8124</orcidid><orcidid>https://orcid.org/0000-0002-5630-5167</orcidid><orcidid>https://orcid.org/0000-0001-8062-9033</orcidid><orcidid>https://orcid.org/0000-0002-1254-6110</orcidid><orcidid>https://orcid.org/0000-0002-9091-1961</orcidid><orcidid>https://orcid.org/0000-0001-9429-0616</orcidid><orcidid>https://orcid.org/0000-0001-8665-3878</orcidid><orcidid>https://orcid.org/0000-0002-3439-7347</orcidid><orcidid>https://orcid.org/0000-0003-1488-5666</orcidid><orcidid>https://orcid.org/0000-0003-2421-6052</orcidid><orcidid>https://orcid.org/0000-0001-5078-4083</orcidid><orcidid>https://orcid.org/0000-0002-9545-4982</orcidid><orcidid>https://orcid.org/0000-0003-1381-3409</orcidid><orcidid>https://orcid.org/0000-0001-5746-0153</orcidid><orcidid>https://orcid.org/0000-0001-7037-1681</orcidid><orcidid>https://orcid.org/0000-0003-3201-2375</orcidid><orcidid>https://orcid.org/0000-0002-1869-5141</orcidid><orcidid>https://orcid.org/0000-0003-1149-466X</orcidid><orcidid>https://orcid.org/0000-0002-1121-4894</orcidid><orcidid>https://orcid.org/0000-0001-6166-9830</orcidid><orcidid>https://orcid.org/0000-0002-4333-2748</orcidid><orcidid>https://orcid.org/0000-0003-4033-0867</orcidid><orcidid>https://orcid.org/0000-0002-3228-9537</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2021-01, Vol.22 (1), p.2-6 |
| issn | 1529-2908 1529-2916 1529-2916 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8020292 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | 631/250 692/420 Adaptive Immunity Adaptive Immunity - immunology Animals BCG Vaccine BCG Vaccine - immunology Biomedical and Life Sciences Biomedicine Bone marrow Cell Differentiation Comment Cytokines Epigenetics Genes Humans Immune response Immune system Immune Tolerance Immune Tolerance - immunology Immunity Immunity, Innate Immunity, Innate - immunology Immunologic Memory Immunologic Memory - immunology Immunological tolerance Immunology Infections Infectious Diseases Life Sciences Observations Pathogens Physiological research Sepsis Tuberculosis Vaccination Vaccines |
| title | Trained immunity, tolerance, priming and differentiation: distinct immunological processes |
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