A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

Unchecked inflammation can result in severe diseases with high mortality, such as macrophage activation syndrome (MAS). MAS and associated cytokine storms have been observed in COVID-19 patients exhibiting systemic hyperinflammation. Interleukin-18 (IL-18), a proinflammatory cytokine belonging to th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100630-100630, Article 100630
Hauptverfasser:	Li, Suzhao, Jiang, Liqiong, Beckmann, Karsten, Højen, Jesper Falkesgaard, Pessara, Ulrich, Powers, Nicholas E., de Graaf, Dennis M., Azam, Tania, Lindenberger, Jared, Eisenmesser, Elan Z., Fischer, Stephan, Dinarello, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - pharmacology Antibodies, Neutralizing - biosynthesis Antibodies, Neutralizing - pharmacology blockade Candida albicans - growth & development Candida albicans - pathogenicity COVID-19 COVID-19 - drug therapy Gene Expression Regulation HEK293 Cells Humans IFNγ IL-1 receptor 7 (IL-1R7) Immunologic Factors - biosynthesis Immunologic Factors - pharmacology Inflammation Interferon-gamma - genetics Interferon-gamma - immunology interleukin-18 (IL-18) Interleukin-18 - genetics Interleukin-18 - immunology Interleukin-6 - genetics Interleukin-6 - immunology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - microbiology Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology macrophage activation syndrome (MAS) Macrophage Activation Syndrome - drug therapy NF-kappa B - genetics NF-kappa B - immunology Primary Cell Culture Receptors, Interleukin-18 - antagonists & inhibitors Receptors, Interleukin-18 - genetics Receptors, Interleukin-18 - immunology SARS-CoV-2 - immunology SARS-CoV-2 - pathogenicity Signal Transduction - drug effects therapeutic Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!