A novel PTPRZ1‐ETV1 fusion in gliomas

The aggressive nature of malignant gliomas and their genetic and clinical heterogeneity present a major challenge in their diagnosis and treatment. Development of targeted therapy brought attention on detecting novel gene fusions, since they represent promising therapeutic targets (eg, TRK inhibitor...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2020-03, Vol.30 (2), p.226-234
Hauptverfasser:	Matjašič, Alenka, Zupan, Andrej, Boštjančič, Emanuela, Pižem, Jože, Popović, Mara, Kolenc, Danijela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Astrocytoma Biomarkers Brain cancer Brain Neoplasms - genetics Brain tumors c-Met protein Child Deoxyribonucleic acid DNA DNA-Binding Proteins - genetics ETS protein ETV1 Ewing's sarcoma Female Gastrointestinal cancer Glioma Glioma - genetics gliomas Humans Inhibitors Kinases Male Middle Aged novel fusion Oligodendroglioma Oncogene Fusion - genetics Oncogene Proteins, Fusion - genetics oncogenes Prostate cancer PTPRZ1 Receptor-Like Protein Tyrosine Phosphatases, Class 5 - genetics RNA‐sequencing Therapeutic applications Therapy Transcription factors Transcription Factors - genetics Tumors
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