Cerebrovascular miRNAs correlate with the clearance of Aβ through perivascular route in younger 3xTg‐AD mice

The “two‐hit vascular hypothesis for Alzheimer's disease (AD)” and amyloid‐β (Aβ) oligomer hypothesis suggest that impaired soluble Aβ oligomers clearance through the cerebral vasculature may be an initial step of the AD process. Soluble Aβ oligomers are driven into perivascular spaces from the...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2020-01, Vol.30 (1), p.92-105
Hauptverfasser:	Fu, Lijuan, Jiang, Ge, Weng, Hope, Dick, Gregory M., Chang, Yanzhong, Kassab, Ghassan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3xTg‐AD mice Alzheimer's disease Alzheimer's disease (AD) Amyloid amyloid‐β (Aβ) Blood flow Blood vessels Brain Capillaries Endothelium Ghrelin Hypotheses Medical innovations MicroRNAs miRNA Modulators Neurodegenerative diseases Oligomers Parenchyma Peripheral blood perivascular drainage Phenotypes vascular miRNAs
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