Relevance of host tau in tau seeding and spreading in tauopathies

Human tau seeding and spreading occur following intracerebral inoculation of brain homogenates obtained from tauopathies in transgenic mice expressing natural or mutant tau, and in wild‐type (WT) mice. The present study was geared to learning about the patterns of tau seeding, the cells involved and...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2020-03, Vol.30 (2), p.298-318
Hauptverfasser:	Ferrer, Isidro, Zelaya, Maria Victoria, Aguiló García, Meritxell, Carmona, Margarita, López‐González, Irene, Andrés‐Benito, Pol, Lidón, Laia, Gavín, Rosalina, Garcia‐Esparcia, Paula, Rio, José Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging (natural) aging‐related tau astrogliopathy Animals Aspartic acid Astrocytes Brain Brain - pathology Conformation Corpus callosum Deposits Extracellular signal-regulated kinase Glial cells globular glial tauopathy Hippocampus Humans Hypothalamus Immunohistochemistry Inclusions Inoculation Kinases Mice Mice, Inbred C57BL Mice, Transgenic Mutants Neurodegenerative diseases Neuronal-glial interactions Neurons Nucleation Oligodendrocytes Paraffin Paraffins primary age‐related tauopathy Rodents seeding Spreading tau Tau protein tau Proteins - metabolism tauopathies Tauopathies - pathology Transgenic mice Ubiquitination
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