Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration

Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclusively in the nucleus at the genomic integration s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-02, Vol.118 (6), p.1-11
Hauptverfasser:	Fukuda, Shinichi, Varshney, Akhil, Fowler, Benjamin J., Wang, Shao-bin, Narendran, Siddharth, Ambati, Kameshwari, Yasuma, Tetsuhiro, Magagnoli, Joseph, Leung, Hannah, Hirahara, Shuichiro, Nagasaka, Yosuke, Yasuma, Reo, Apicella, Ivana, Pereira, Felipe, Makin, Ryan D., Magner, Eamonn, Liu, Xinan, Sun, Jian, Wang, Mo, Baker, Kirstie, Marion, Kenneth M., Huang, Xiwen, Baghdasaryan, Elmira, Ambati, Meenakshi, Ambati, Vidya L., Pandey, Akshat, Pandya, Lekha, Cummings, Tammy, Banerjee, Daipayan, Huang, Peirong, Yerramothu, Praveen, Tolstonog, Genrich V., Held, Ulrike, Erwin, Jennifer A., Paquola, Apua C. M., Herdy, Joseph R., Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Darwish, Shaban, Singh, Ramendra K., Mozaffari, Saghar, Bhattarai, Deepak, Kim, Kyung Bo, Hardin, James W., Bennett, Charles L., Hinton, David R., Hanson, Timothy E., Röver, Christian, Parang, Keykavous, Kerur, Nagaraj, Liu, Jinze, Werner, Brian C., Sutton, S.Scott, Sadda, Srinivas R., Schumann, Gerald G., Gelfand, Bradley D., Gage, Fred H., Ambati, Jayakrishna
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences
Online-Zugang:	Volltext
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