Aptamer Blocking Strategy Inhibits SARS‐CoV‐2 Virus Infection

The COVID‐19 pandemic caused by SARS‐CoV‐2 is threating global health. Inhibiting interaction of the receptor‐binding domain of SARS‐CoV‐2 S protein (SRBD) and human ACE2 receptor is a promising treatment strategy. However, SARS‐CoV‐2 neutralizing antibodies are compromised by their risk of antibody...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (18), p.10266-10272
Hauptverfasser:	Sun, Miao, Liu, Siwen, Wei, Xinyu, Wan, Shuang, Huang, Mengjiao, Song, Ting, Lu, Yao, Weng, Xiaonan, Lin, Zhu, Chen, Honglin, Song, Yanling, Yang, Chaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Affinity Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Antibodies Antiviral Agents - chemistry Antiviral Agents - pharmacology Aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - pharmacology Binding Blocking COVID-19 COVID-19 - drug therapy COVID-19 - metabolism Drug Discovery Global health Health risks HEK293 Cells Humans Infections Molecular docking Molecular Docking Simulation neutralization therapy Pandemics Protein Binding - drug effects Protein Interaction Domains and Motifs - drug effects Public health Receptors Room temperature SARS-CoV-2 SARS-CoV-2 - chemistry SARS-CoV-2 - drug effects SARS-CoV-2 - physiology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism Strategy Viral diseases viral infections Viruses
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