Monocyte CD169 expression in COVID‐19 patients upon intensive care unit admission
During the second surge of COVID‐19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec‐1, one of the numerous IFN‐stimulated genes) upon admission to intensive care units of 45 patients with RT‐PCR‐confirmed SARS‐CoV2 pulmonary infection. Overall, CD169 expression was...
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| Veröffentlicht in: | Cytometry. Part A 2021-05, Vol.99 (5), p.466-471 |
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| container_title | Cytometry. Part A |
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| creator | Ortillon, Marine Coudereau, Remy Cour, Martin Rimmelé, Thomas Godignon, Marine Gossez, Morgane Yonis, Hodane Argaud, Laurent Lukaszewicz, Anne‐Claire Venet, Fabienne Monneret, Guillaume |
| description | During the second surge of COVID‐19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec‐1, one of the numerous IFN‐stimulated genes) upon admission to intensive care units of 45 patients with RT‐PCR‐confirmed SARS‐CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID‐19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID‐19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis. |
| doi_str_mv | 10.1002/cyto.a.24315 |
| format | Article |
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Overall, CD169 expression was strongly induced on circulating monocytes of COVID‐19 patients compared with healthy donors and patients with bacterial sepsis. 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| ispartof | Cytometry. Part A, 2021-05, Vol.99 (5), p.466-471 |
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| source | Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Brief Report CD169 COVID-19 COVID‐19 Fast Track Emergency medical care Emergency medical services Etiology Hospitals Intensive care Intensive care units Interferon Life Sciences monocyte Monocytes Sepsis Severe acute respiratory syndrome coronavirus 2 |
| title | Monocyte CD169 expression in COVID‐19 patients upon intensive care unit admission |
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