Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action

Bacterial natural products have inspired the development of numerous antibiotics in use today. As resistance to existing antibiotics has become more prevalent, new antibiotic lead structures and activities are desperately needed. An increasing number of natural product biosynthetic gene clusters, to...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-08, Vol.142 (33), p.14158-14168
Hauptverfasser:	Chu, John, Koirala, Bimal, Forelli, Nicholas, Vila-Farres, Xavier, Ternei, Melinda A, Ali, Thahmina, Colosimo, Dominic A, Brady, Sean F
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology Computational Biology Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects
Online-Zugang:	Volltext
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