Water vapor therapy (Rezūm) for lower urinary tract symptoms related to benign prostatic hyperplasia: early results from the first Italian multicentric study

Purpose Rezūm is the latest developed minimally invasive treatment for benign prostatic hyperplasia (BPH). We aimed to carefully assess the functional outcomes of patients treated with Rezūm for BPH. Methods We prospectively followed 135 consecutive patients treated by Rezūm at 5 institutions from J...

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Veröffentlicht in:World journal of urology 2021-10, Vol.39 (10), p.3875-3880
Hauptverfasser: Siena, Giampaolo, Cindolo, L., Ferrari, G., Maruzzi, D., Fasolis, G., Condorelli, S. V., Varvello, F., Visalli, F., Rabito, S., Toso, S., Caroassai, S., Mari, A., Viola, L., Somani, B. K., Carini, M.
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container_end_page 3880
container_issue 10
container_start_page 3875
container_title World journal of urology
container_volume 39
creator Siena, Giampaolo
Cindolo, L.
Ferrari, G.
Maruzzi, D.
Fasolis, G.
Condorelli, S. V.
Varvello, F.
Visalli, F.
Rabito, S.
Toso, S.
Caroassai, S.
Mari, A.
Viola, L.
Somani, B. K.
Carini, M.
description Purpose Rezūm is the latest developed minimally invasive treatment for benign prostatic hyperplasia (BPH). We aimed to carefully assess the functional outcomes of patients treated with Rezūm for BPH. Methods We prospectively followed 135 consecutive patients treated by Rezūm at 5 institutions from June 2019 to August 2020. The International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI SF), the Overactive Bladder Questionnaire-Short Form (OAB-q SF) score, the International Index of Erectile Function (IIEF-5) and questions 9 and 10 to assess ejaculatory dysfunction were recorded. Election criteria were age > 18, no prior prostate interventions, IPSS ≥ 13, post-void residual ≤ 250 mL, prostate volume between 30 and 120 cc. Results The median operative time was 10.5 (IQR 8.7–15) min. All patients were dismissed few hours after surgery with indwelling urinary catheter that was removed after a median of 7 (IQR 7–10) days. A significantly decrease of IPSS from baseline at first ( p  = 0.001) and third ( p  
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V. ; Varvello, F. ; Visalli, F. ; Rabito, S. ; Toso, S. ; Caroassai, S. ; Mari, A. ; Viola, L. ; Somani, B. K. ; Carini, M.</creator><creatorcontrib>Siena, Giampaolo ; Cindolo, L. ; Ferrari, G. ; Maruzzi, D. ; Fasolis, G. ; Condorelli, S. V. ; Varvello, F. ; Visalli, F. ; Rabito, S. ; Toso, S. ; Caroassai, S. ; Mari, A. ; Viola, L. ; Somani, B. K. ; Carini, M.</creatorcontrib><description>Purpose Rezūm is the latest developed minimally invasive treatment for benign prostatic hyperplasia (BPH). We aimed to carefully assess the functional outcomes of patients treated with Rezūm for BPH. Methods We prospectively followed 135 consecutive patients treated by Rezūm at 5 institutions from June 2019 to August 2020. The International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI SF), the Overactive Bladder Questionnaire-Short Form (OAB-q SF) score, the International Index of Erectile Function (IIEF-5) and questions 9 and 10 to assess ejaculatory dysfunction were recorded. Election criteria were age &gt; 18, no prior prostate interventions, IPSS ≥ 13, post-void residual ≤ 250 mL, prostate volume between 30 and 120 cc. Results The median operative time was 10.5 (IQR 8.7–15) min. All patients were dismissed few hours after surgery with indwelling urinary catheter that was removed after a median of 7 (IQR 7–10) days. A significantly decrease of IPSS from baseline at first ( p  = 0.001) and third ( p  &lt; 0.0001) month after surgery was reported. No difference was reported in terms of ICIQ-UI SF score postoperatively. A mild reduction of the OAB-q SF score was reported at 1 month from surgery ( p  = 0.06) that turned significant at 3 months postoperatively ( p  &lt; 0.0001). A slight but statistically significant increase of the IIEF-5 score was reported from baseline at 6 months ( p  = 0.04). Postoperatively, patients reported a significantly decrease of ejaculatory dysfunction after alpha-blocker interruption. Conclusion Rezūm treatment is a feasible minimally invasive option for patients with BPH symptoms and showed optimal early functional outcomes.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-021-03642-4</identifier><identifier>PMID: 33787986</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Catheters ; Follow-Up Studies ; Genital diseases ; Humans ; Hyperplasia ; Hyperthermia, Induced - instrumentation ; Italy ; Lower Urinary Tract Symptoms - etiology ; Lower Urinary Tract Symptoms - therapy ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Nephrology ; Oncology ; Original ; Original Article ; Patients ; Prospective Studies ; Prostate ; Prostatic Hyperplasia - complications ; Questionnaires ; Recovery of Function ; Statistical analysis ; Steam ; Surgery ; Surveys and Questionnaires ; Treatment Outcome ; Urinary tract ; Urology ; Water vapor</subject><ispartof>World journal of urology, 2021-10, Vol.39 (10), p.3875-3880</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b9e1ab2cff326b543e5918e48aeb8b4105a1a32bd0a77b4d03591f7a0b79886f3</citedby><cites>FETCH-LOGICAL-c474t-b9e1ab2cff326b543e5918e48aeb8b4105a1a32bd0a77b4d03591f7a0b79886f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-021-03642-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-021-03642-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33787986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siena, Giampaolo</creatorcontrib><creatorcontrib>Cindolo, L.</creatorcontrib><creatorcontrib>Ferrari, G.</creatorcontrib><creatorcontrib>Maruzzi, D.</creatorcontrib><creatorcontrib>Fasolis, G.</creatorcontrib><creatorcontrib>Condorelli, S. V.</creatorcontrib><creatorcontrib>Varvello, F.</creatorcontrib><creatorcontrib>Visalli, F.</creatorcontrib><creatorcontrib>Rabito, S.</creatorcontrib><creatorcontrib>Toso, S.</creatorcontrib><creatorcontrib>Caroassai, S.</creatorcontrib><creatorcontrib>Mari, A.</creatorcontrib><creatorcontrib>Viola, L.</creatorcontrib><creatorcontrib>Somani, B. K.</creatorcontrib><creatorcontrib>Carini, M.</creatorcontrib><title>Water vapor therapy (Rezūm) for lower urinary tract symptoms related to benign prostatic hyperplasia: early results from the first Italian multicentric study</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose Rezūm is the latest developed minimally invasive treatment for benign prostatic hyperplasia (BPH). We aimed to carefully assess the functional outcomes of patients treated with Rezūm for BPH. Methods We prospectively followed 135 consecutive patients treated by Rezūm at 5 institutions from June 2019 to August 2020. The International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI SF), the Overactive Bladder Questionnaire-Short Form (OAB-q SF) score, the International Index of Erectile Function (IIEF-5) and questions 9 and 10 to assess ejaculatory dysfunction were recorded. Election criteria were age &gt; 18, no prior prostate interventions, IPSS ≥ 13, post-void residual ≤ 250 mL, prostate volume between 30 and 120 cc. Results The median operative time was 10.5 (IQR 8.7–15) min. All patients were dismissed few hours after surgery with indwelling urinary catheter that was removed after a median of 7 (IQR 7–10) days. A significantly decrease of IPSS from baseline at first ( p  = 0.001) and third ( p  &lt; 0.0001) month after surgery was reported. No difference was reported in terms of ICIQ-UI SF score postoperatively. A mild reduction of the OAB-q SF score was reported at 1 month from surgery ( p  = 0.06) that turned significant at 3 months postoperatively ( p  &lt; 0.0001). A slight but statistically significant increase of the IIEF-5 score was reported from baseline at 6 months ( p  = 0.04). Postoperatively, patients reported a significantly decrease of ejaculatory dysfunction after alpha-blocker interruption. 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V.</au><au>Varvello, F.</au><au>Visalli, F.</au><au>Rabito, S.</au><au>Toso, S.</au><au>Caroassai, S.</au><au>Mari, A.</au><au>Viola, L.</au><au>Somani, B. K.</au><au>Carini, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Water vapor therapy (Rezūm) for lower urinary tract symptoms related to benign prostatic hyperplasia: early results from the first Italian multicentric study</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>39</volume><issue>10</issue><spage>3875</spage><epage>3880</epage><pages>3875-3880</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose Rezūm is the latest developed minimally invasive treatment for benign prostatic hyperplasia (BPH). We aimed to carefully assess the functional outcomes of patients treated with Rezūm for BPH. Methods We prospectively followed 135 consecutive patients treated by Rezūm at 5 institutions from June 2019 to August 2020. The International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI SF), the Overactive Bladder Questionnaire-Short Form (OAB-q SF) score, the International Index of Erectile Function (IIEF-5) and questions 9 and 10 to assess ejaculatory dysfunction were recorded. Election criteria were age &gt; 18, no prior prostate interventions, IPSS ≥ 13, post-void residual ≤ 250 mL, prostate volume between 30 and 120 cc. Results The median operative time was 10.5 (IQR 8.7–15) min. All patients were dismissed few hours after surgery with indwelling urinary catheter that was removed after a median of 7 (IQR 7–10) days. A significantly decrease of IPSS from baseline at first ( p  = 0.001) and third ( p  &lt; 0.0001) month after surgery was reported. No difference was reported in terms of ICIQ-UI SF score postoperatively. A mild reduction of the OAB-q SF score was reported at 1 month from surgery ( p  = 0.06) that turned significant at 3 months postoperatively ( p  &lt; 0.0001). A slight but statistically significant increase of the IIEF-5 score was reported from baseline at 6 months ( p  = 0.04). Postoperatively, patients reported a significantly decrease of ejaculatory dysfunction after alpha-blocker interruption. Conclusion Rezūm treatment is a feasible minimally invasive option for patients with BPH symptoms and showed optimal early functional outcomes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33787986</pmid><doi>10.1007/s00345-021-03642-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; SpringerLink Journals
subjects Aged
Catheters
Follow-Up Studies
Genital diseases
Humans
Hyperplasia
Hyperthermia, Induced - instrumentation
Italy
Lower Urinary Tract Symptoms - etiology
Lower Urinary Tract Symptoms - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Oncology
Original
Original Article
Patients
Prospective Studies
Prostate
Prostatic Hyperplasia - complications
Questionnaires
Recovery of Function
Statistical analysis
Steam
Surgery
Surveys and Questionnaires
Treatment Outcome
Urinary tract
Urology
Water vapor
title Water vapor therapy (Rezūm) for lower urinary tract symptoms related to benign prostatic hyperplasia: early results from the first Italian multicentric study
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