Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging

Cardiac senescence is a typical chronic frailty condition in the elderly population, and cellular aging is often associated with oxidative stress. The mitochondrial-membrane flavoenzyme monoamine oxidase A (MAO A) catalyzes the oxidative deamination of neurotransmitters, and its expression increases...

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Veröffentlicht in:	ACS chemical biology 2020-07, Vol.15 (7), p.1795-1800
Hauptverfasser:	Iacovino, Luca Giacinto, Manzella, Nicola, Resta, Jessica, Vanoni, Maria Antonietta, Rotilio, Laura, Pisani, Leonardo, Edmondson, Dale Edward, Parini, Angelo, Mattevi, Andrea, Mialet-Perez, Jeanne, Binda, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biochemistry, Molecular Biology Cell Line Cellular Senescence - physiology Humans Hydrogen Peroxide - metabolism Letters Life Sciences Lysine - genetics Monoamine Oxidase - genetics Monoamine Oxidase - metabolism Mutation Myoblasts, Cardiac - metabolism Myocardium - metabolism Protein Engineering Rats Structural Biology
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