A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing

Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism of drug action. A chemical-induced gene expression profile provides a mechanistic signature of phenotypic response; however, the use of such data is limited by t...

Ausführliche Beschreibung