Protein kinase C fusion proteins are paradoxically loss of function in cancer

Within the AGC kinase superfamily, gene fusions resulting from chromosomal rearrangements have been most frequently described for protein kinase C (PKC), with gene fragments encoding either the C-terminal catalytic domain or the N-terminal regulatory moiety fused to other genes. Kinase fusions that...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100445-100445, Article 100445
Hauptverfasser:	Van, An-Angela N., Kunkel, Maya T., Baffi, Timothy R., Lordén, Gema, Antal, Corina E., Banerjee, Sourav, Newton, Alexandra C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoinhibition Binding Sites cancer Catalytic Domain Cell Line, Tumor Chlorocebus aethiops constitutively active COS Cells Diglycerides - metabolism dominant negative Fluorescence Resonance Energy Transfer - methods gene fusions Humans loss of function Loss of Function Mutation - genetics Neoplasms - metabolism Phosphorylation protein degradation Protein Domains protein kinase C (PKC) Protein Kinase C - genetics Protein Kinase C - metabolism Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism regulatory domain
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