Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology
Background. Xiaochaihu decoction (XD) has demonstrated the pharmacodynamics on acute pancreatitis. This study was aimed at investigating the material and molecular basis of Xiaochaihu decoction. Methods. Firstly, compounds of seven herbs containing XD were collected from the TCMSP, ETCM, and BATMAN-...
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| description | Background. Xiaochaihu decoction (XD) has demonstrated the pharmacodynamics on acute pancreatitis. This study was aimed at investigating the material and molecular basis of Xiaochaihu decoction. Methods. Firstly, compounds of seven herbs containing XD were collected from the TCMSP, ETCM, and BATMAN-TCM databases, and the putative targets of pancreatitis were obtained from the OMIM, TTD, and GeneCards databases. Then, the PPI network was constructed according to the matching results between XD potential targets and pancreatic neoplasm targets. Furthermore, enrichment analysis on GO and KEGG by DAVID utilized bioinformatics resources. Finally, molecular docking was performed to simulate the interaction between the active compound of XD and putative targets. In an in vitro experiment, AR42J cells were induced by LPS and then treated with Quercetin (25, 50, and 100 μM) or XCHD. The IL-6, TNF-α, and IL-1β levels were detected by ELISA kit, MAPK3 and TP53 mRNA expressions were measured by qRT-PCR, and the proteins of MAPK3 and TP53 expressions were measured by WB. Results. A total of 196 active ingredients and 91 putative targets were selected. The PPI network analysis demonstrated that Quercetin was the candidate agent and MAPK3, IL-6, and TP53 were the potential targets for the XD treatment of acute pancreatitis. The KEGG analysis revealed that pathways in cancers, TNF signaling way, and MAPK signaling way might play an important role in pancreatitis therapy. And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53. An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-α, and IL-1β levels and MAPK3 and TP53. Conclusion. This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis. |
| doi_str_mv | 10.1155/2021/6621682 |
| format | Article |
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Xiaochaihu decoction (XD) has demonstrated the pharmacodynamics on acute pancreatitis. This study was aimed at investigating the material and molecular basis of Xiaochaihu decoction. Methods. Firstly, compounds of seven herbs containing XD were collected from the TCMSP, ETCM, and BATMAN-TCM databases, and the putative targets of pancreatitis were obtained from the OMIM, TTD, and GeneCards databases. Then, the PPI network was constructed according to the matching results between XD potential targets and pancreatic neoplasm targets. Furthermore, enrichment analysis on GO and KEGG by DAVID utilized bioinformatics resources. Finally, molecular docking was performed to simulate the interaction between the active compound of XD and putative targets. In an in vitro experiment, AR42J cells were induced by LPS and then treated with Quercetin (25, 50, and 100 μM) or XCHD. The IL-6, TNF-α, and IL-1β levels were detected by ELISA kit, MAPK3 and TP53 mRNA expressions were measured by qRT-PCR, and the proteins of MAPK3 and TP53 expressions were measured by WB. Results. A total of 196 active ingredients and 91 putative targets were selected. The PPI network analysis demonstrated that Quercetin was the candidate agent and MAPK3, IL-6, and TP53 were the potential targets for the XD treatment of acute pancreatitis. The KEGG analysis revealed that pathways in cancers, TNF signaling way, and MAPK signaling way might play an important role in pancreatitis therapy. And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53. An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-α, and IL-1β levels and MAPK3 and TP53. Conclusion. This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/6621682</identifier><identifier>PMID: 33824873</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Analysis ; Anti-inflammatory drugs ; Apoptosis ; Bioinformatics ; Care and treatment ; Cell culture ; Chinese medicine ; Composition ; Computational Biology ; Cytokines ; Databases, Nucleic Acid ; Disease ; Dosage and administration ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; Experiments ; Humans ; Identification and classification ; IL-1β ; Inflammation ; Interleukin 6 ; Kinases ; Lipopolysaccharides ; MAP kinase ; Materia medica, Vegetable ; Medical research ; Medicine, Chinese ; Molecular docking ; Molecular Docking Simulation ; mRNA ; Multiple organ dysfunction syndrome ; Network analysis ; p53 Protein ; Pancreas ; Pancreatitis ; Pancreatitis - drug therapy ; Pancreatitis - metabolism ; Pancreatitis - pathology ; Pharmacodynamics ; Pharmacology ; Pharmacology, Experimental ; Plant extracts ; Properties ; Protein-protein interactions ; Proteins ; Quercetin ; Signal Transduction - drug effects ; Signaling ; Software ; Statistical analysis ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>BioMed research international, 2021, Vol.2021, p.6621682-11</ispartof><rights>Copyright © 2021 Lianghui Zhan et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Lianghui Zhan et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Lianghui Zhan et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-a38ffa33f1e2be140151177f8b6a5d8067e91f8c72b7de7442a05f6acc6d76583</citedby><cites>FETCH-LOGICAL-c504t-a38ffa33f1e2be140151177f8b6a5d8067e91f8c72b7de7442a05f6acc6d76583</cites><orcidid>0000-0002-8076-9922 ; 0000-0002-7938-8444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007340/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007340/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33824873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Imran, Ali</contributor><contributor>Ali Imran</contributor><creatorcontrib>Zhan, Lianghui</creatorcontrib><creatorcontrib>Pu, Jinbao</creatorcontrib><creatorcontrib>Hu, Yijuan</creatorcontrib><creatorcontrib>Xu, Pan</creatorcontrib><creatorcontrib>Liang, Weiqing</creatorcontrib><creatorcontrib>Ji, Chunlian</creatorcontrib><title>Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Xiaochaihu decoction (XD) has demonstrated the pharmacodynamics on acute pancreatitis. This study was aimed at investigating the material and molecular basis of Xiaochaihu decoction. Methods. Firstly, compounds of seven herbs containing XD were collected from the TCMSP, ETCM, and BATMAN-TCM databases, and the putative targets of pancreatitis were obtained from the OMIM, TTD, and GeneCards databases. Then, the PPI network was constructed according to the matching results between XD potential targets and pancreatic neoplasm targets. Furthermore, enrichment analysis on GO and KEGG by DAVID utilized bioinformatics resources. Finally, molecular docking was performed to simulate the interaction between the active compound of XD and putative targets. In an in vitro experiment, AR42J cells were induced by LPS and then treated with Quercetin (25, 50, and 100 μM) or XCHD. The IL-6, TNF-α, and IL-1β levels were detected by ELISA kit, MAPK3 and TP53 mRNA expressions were measured by qRT-PCR, and the proteins of MAPK3 and TP53 expressions were measured by WB. Results. A total of 196 active ingredients and 91 putative targets were selected. The PPI network analysis demonstrated that Quercetin was the candidate agent and MAPK3, IL-6, and TP53 were the potential targets for the XD treatment of acute pancreatitis. The KEGG analysis revealed that pathways in cancers, TNF signaling way, and MAPK signaling way might play an important role in pancreatitis therapy. And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53. An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-α, and IL-1β levels and MAPK3 and TP53. Conclusion. This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.</description><subject>Analysis</subject><subject>Anti-inflammatory drugs</subject><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Care and treatment</subject><subject>Cell culture</subject><subject>Chinese medicine</subject><subject>Composition</subject><subject>Computational Biology</subject><subject>Cytokines</subject><subject>Databases, Nucleic Acid</subject><subject>Disease</subject><subject>Dosage and administration</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Experiments</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Kinases</subject><subject>Lipopolysaccharides</subject><subject>MAP kinase</subject><subject>Materia medica, Vegetable</subject><subject>Medical research</subject><subject>Medicine, Chinese</subject><subject>Molecular docking</subject><subject>Molecular Docking Simulation</subject><subject>mRNA</subject><subject>Multiple organ dysfunction syndrome</subject><subject>Network analysis</subject><subject>p53 Protein</subject><subject>Pancreas</subject><subject>Pancreatitis</subject><subject>Pancreatitis - drug therapy</subject><subject>Pancreatitis - metabolism</subject><subject>Pancreatitis - pathology</subject><subject>Pharmacodynamics</subject><subject>Pharmacology</subject><subject>Pharmacology, Experimental</subject><subject>Plant extracts</subject><subject>Properties</subject><subject>Protein-protein interactions</subject><subject>Proteins</subject><subject>Quercetin</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1rFDEYhwdRbKm9eZYBL4KuzXcyF2Gt9QOKemjBW3g3k-ykziRtMtNS6B9vxl1X66G5JCRPnjdv-FXVc4zeYsz5EUEEHwlBsFDkUbVPKGYLgRl-vFtTulcd5nyBylBYoEY8rfYoVYQpSferu_Ng4rVNPqzrsbP19w7SACb2cX1bR1f_8BBNB76b6g_WRDP6GGoffrNnycI42DDO4NJMY7kOwcy7fvS5fg_ZtnXcwF_teBPTz3sFnlVPHPTZHm7ng-r848nZ8efF6bdPX46XpwvDERsXQJVzQKnDlqwsZghzjKV0aiWAtwoJaRvslJFkJVsrGSOAuBNgjGil4IoeVO823stpNdjWlCcn6PVl8gOkWx3B6_snwXd6Ha-1QkhShorg1VaQ4tVk86gHn43tewg2TlkTXv4VCSVn9OV_6EWcUijtzZQighOp_lJr6K32wcVS18xSvRSNaDgjRDxMKUZ4U1SFerOhTIo5J-t2jWGk55ToOSV6m5KCv_j3M3bwn0wU4PUG6Hxo4cY_rPsFXBPDNg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Zhan, Lianghui</creator><creator>Pu, Jinbao</creator><creator>Hu, Yijuan</creator><creator>Xu, Pan</creator><creator>Liang, Weiqing</creator><creator>Ji, Chunlian</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8076-9922</orcidid><orcidid>https://orcid.org/0000-0002-7938-8444</orcidid></search><sort><creationdate>2021</creationdate><title>Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology</title><author>Zhan, Lianghui ; Pu, Jinbao ; Hu, Yijuan ; Xu, Pan ; Liang, Weiqing ; Ji, Chunlian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-a38ffa33f1e2be140151177f8b6a5d8067e91f8c72b7de7442a05f6acc6d76583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Anti-inflammatory drugs</topic><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Care and treatment</topic><topic>Cell culture</topic><topic>Chinese medicine</topic><topic>Composition</topic><topic>Computational Biology</topic><topic>Cytokines</topic><topic>Databases, Nucleic Acid</topic><topic>Disease</topic><topic>Dosage and administration</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Experiments</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Kinases</topic><topic>Lipopolysaccharides</topic><topic>MAP kinase</topic><topic>Materia medica, Vegetable</topic><topic>Medical research</topic><topic>Medicine, Chinese</topic><topic>Molecular docking</topic><topic>Molecular Docking Simulation</topic><topic>mRNA</topic><topic>Multiple organ dysfunction syndrome</topic><topic>Network analysis</topic><topic>p53 Protein</topic><topic>Pancreas</topic><topic>Pancreatitis</topic><topic>Pancreatitis - drug therapy</topic><topic>Pancreatitis - metabolism</topic><topic>Pancreatitis - pathology</topic><topic>Pharmacodynamics</topic><topic>Pharmacology</topic><topic>Pharmacology, Experimental</topic><topic>Plant extracts</topic><topic>Properties</topic><topic>Protein-protein interactions</topic><topic>Proteins</topic><topic>Quercetin</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhan, Lianghui</creatorcontrib><creatorcontrib>Pu, Jinbao</creatorcontrib><creatorcontrib>Hu, Yijuan</creatorcontrib><creatorcontrib>Xu, Pan</creatorcontrib><creatorcontrib>Liang, Weiqing</creatorcontrib><creatorcontrib>Ji, Chunlian</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhan, Lianghui</au><au>Pu, Jinbao</au><au>Hu, Yijuan</au><au>Xu, Pan</au><au>Liang, Weiqing</au><au>Ji, Chunlian</au><au>Imran, Ali</au><au>Ali Imran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>6621682</spage><epage>11</epage><pages>6621682-11</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Xiaochaihu decoction (XD) has demonstrated the pharmacodynamics on acute pancreatitis. This study was aimed at investigating the material and molecular basis of Xiaochaihu decoction. Methods. Firstly, compounds of seven herbs containing XD were collected from the TCMSP, ETCM, and BATMAN-TCM databases, and the putative targets of pancreatitis were obtained from the OMIM, TTD, and GeneCards databases. Then, the PPI network was constructed according to the matching results between XD potential targets and pancreatic neoplasm targets. Furthermore, enrichment analysis on GO and KEGG by DAVID utilized bioinformatics resources. Finally, molecular docking was performed to simulate the interaction between the active compound of XD and putative targets. In an in vitro experiment, AR42J cells were induced by LPS and then treated with Quercetin (25, 50, and 100 μM) or XCHD. The IL-6, TNF-α, and IL-1β levels were detected by ELISA kit, MAPK3 and TP53 mRNA expressions were measured by qRT-PCR, and the proteins of MAPK3 and TP53 expressions were measured by WB. Results. A total of 196 active ingredients and 91 putative targets were selected. The PPI network analysis demonstrated that Quercetin was the candidate agent and MAPK3, IL-6, and TP53 were the potential targets for the XD treatment of acute pancreatitis. The KEGG analysis revealed that pathways in cancers, TNF signaling way, and MAPK signaling way might play an important role in pancreatitis therapy. And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53. An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-α, and IL-1β levels and MAPK3 and TP53. Conclusion. This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>33824873</pmid><doi>10.1155/2021/6621682</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8076-9922</orcidid><orcidid>https://orcid.org/0000-0002-7938-8444</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Anti-inflammatory drugs Apoptosis Bioinformatics Care and treatment Cell culture Chinese medicine Composition Computational Biology Cytokines Databases, Nucleic Acid Disease Dosage and administration Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Experiments Humans Identification and classification IL-1β Inflammation Interleukin 6 Kinases Lipopolysaccharides MAP kinase Materia medica, Vegetable Medical research Medicine, Chinese Molecular docking Molecular Docking Simulation mRNA Multiple organ dysfunction syndrome Network analysis p53 Protein Pancreas Pancreatitis Pancreatitis - drug therapy Pancreatitis - metabolism Pancreatitis - pathology Pharmacodynamics Pharmacology Pharmacology, Experimental Plant extracts Properties Protein-protein interactions Proteins Quercetin Signal Transduction - drug effects Signaling Software Statistical analysis Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T04%3A51%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Uncovering%20the%20Pharmacology%20of%20Xiaochaihu%20Decoction%20in%20the%20Treatment%20of%20Acute%20Pancreatitis%20Based%20on%20the%20Network%20Pharmacology&rft.jtitle=BioMed%20research%20international&rft.au=Zhan,%20Lianghui&rft.date=2021&rft.volume=2021&rft.spage=6621682&rft.epage=11&rft.pages=6621682-11&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2021/6621682&rft_dat=%3Cgale_pubme%3EA696954226%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2508265278&rft_id=info:pmid/33824873&rft_galeid=A696954226&rfr_iscdi=true |