COVID-19 in Adults With Congenital Heart Disease
Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. Adu...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2021-04, Vol.77 (13), p.1644-1655 |
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| creator | Broberg, Craig S Kovacs, Adrienne H Sadeghi, Soraya Rosenbaum, Marlon S Lewis, Matthew J Carazo, Matthew R Rodriguez, 3rd, Fred H Halpern, Dan G Feinberg, Jodi Galilea, Francisca Arancibia Baraona, Fernando Cedars, Ari M Ko, Jong M Porayette, Prashob Maldonado, Jennifer Sarubbi, Berardo Fusco, Flavia Frogoudaki, Alexandra A Nir, Amiram Chaudhry, Anisa John, Anitha S Karbassi, Arsha Hoskoppal, Arvind K Frischhertz, Benjamin P Hendrickson, Benjamin Bouma, Berto J Rodriguez-Monserrate, Carla P Broda, Christopher R Tobler, Daniel Gregg, David Martinez-Quintana, Efren Yeung, Elizabeth Krieger, Eric V Ruperti-Repilado, Francisco J Giannakoulas, George Lui, George K Ephrem, Georges Singh, Harsimran S Almeneisi, Hassan Mk Bartlett, Heather L Lindsay, Ian Grewal, Jasmine Nicolarsen, Jeremy Araujo, John J Cramer, Jonathan W Bouchardy, Judith Al Najashi, Khalid Ryan, Kristi Alshawabkeh, Laith Andrade, Lauren Ladouceur, Magalie Schwerzmann, Markus Greutmann, Matthias Meras, Pablo Ferrero, Paolo Dehghani, Payam Tung, Poyee P Garcia-Orta, Rocio Tompkins, Rose O Gendi, Salwa M Cohen, Scott Klewer, Scott Hascoet, Sebastien Mohammadzadeh, Shabnam Upadhyay, Shailendra Fisher, Stacy D Cook, Stephen Cotts, Timothy B Aboulhosn, Jamil A |
| description | Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications.
This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes.
Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined.
From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not.
COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity. |
| doi_str_mv | 10.1016/j.jacc.2021.02.023 |
| format | Article |
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This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes.
Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined.
From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not.
COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2021.02.023</identifier><identifier>PMID: 33795039</identifier><language>eng</language><publisher>United States: by the American College of Cardiology Foundation. Published by Elsevier</publisher><subject>Adult ; Cardiac Surgical Procedures - methods ; Cardiac Surgical Procedures - statistics & numerical data ; Causality ; Comorbidity ; COVID-19 - mortality ; COVID-19 - therapy ; COVID-19 Testing - methods ; Cyanosis - diagnosis ; Cyanosis - etiology ; Cyanosis - mortality ; Female ; Global Health - statistics & numerical data ; Heart Defects, Congenital - classification ; Heart Defects, Congenital - epidemiology ; Heart Defects, Congenital - physiopathology ; Heart Defects, Congenital - therapy ; Hospitalization - statistics & numerical data ; Humans ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - mortality ; Male ; Mortality ; Original Investigation ; Patient Acuity ; Risk Factors ; SARS-CoV-2 - isolation & purification ; Symptom Assessment</subject><ispartof>Journal of the American College of Cardiology, 2021-04, Vol.77 (13), p.1644-1655</ispartof><rights>Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>2021 by the American College of Cardiology Foundation. Published by Elsevier. 2021 American College of Cardiology Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-183674855e64b81bc867e13fc5657beacc77f2e96d615f62e9d3f5587be469573</citedby><cites>FETCH-LOGICAL-c402t-183674855e64b81bc867e13fc5657beacc77f2e96d615f62e9d3f5587be469573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33795039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broberg, Craig S</creatorcontrib><creatorcontrib>Kovacs, Adrienne H</creatorcontrib><creatorcontrib>Sadeghi, Soraya</creatorcontrib><creatorcontrib>Rosenbaum, Marlon S</creatorcontrib><creatorcontrib>Lewis, Matthew J</creatorcontrib><creatorcontrib>Carazo, Matthew R</creatorcontrib><creatorcontrib>Rodriguez, 3rd, Fred H</creatorcontrib><creatorcontrib>Halpern, Dan G</creatorcontrib><creatorcontrib>Feinberg, Jodi</creatorcontrib><creatorcontrib>Galilea, Francisca Arancibia</creatorcontrib><creatorcontrib>Baraona, Fernando</creatorcontrib><creatorcontrib>Cedars, Ari M</creatorcontrib><creatorcontrib>Ko, Jong M</creatorcontrib><creatorcontrib>Porayette, Prashob</creatorcontrib><creatorcontrib>Maldonado, Jennifer</creatorcontrib><creatorcontrib>Sarubbi, Berardo</creatorcontrib><creatorcontrib>Fusco, Flavia</creatorcontrib><creatorcontrib>Frogoudaki, Alexandra A</creatorcontrib><creatorcontrib>Nir, Amiram</creatorcontrib><creatorcontrib>Chaudhry, Anisa</creatorcontrib><creatorcontrib>John, Anitha S</creatorcontrib><creatorcontrib>Karbassi, Arsha</creatorcontrib><creatorcontrib>Hoskoppal, Arvind K</creatorcontrib><creatorcontrib>Frischhertz, Benjamin P</creatorcontrib><creatorcontrib>Hendrickson, Benjamin</creatorcontrib><creatorcontrib>Bouma, Berto J</creatorcontrib><creatorcontrib>Rodriguez-Monserrate, Carla P</creatorcontrib><creatorcontrib>Broda, Christopher R</creatorcontrib><creatorcontrib>Tobler, Daniel</creatorcontrib><creatorcontrib>Gregg, David</creatorcontrib><creatorcontrib>Martinez-Quintana, Efren</creatorcontrib><creatorcontrib>Yeung, Elizabeth</creatorcontrib><creatorcontrib>Krieger, Eric V</creatorcontrib><creatorcontrib>Ruperti-Repilado, Francisco J</creatorcontrib><creatorcontrib>Giannakoulas, George</creatorcontrib><creatorcontrib>Lui, George K</creatorcontrib><creatorcontrib>Ephrem, Georges</creatorcontrib><creatorcontrib>Singh, Harsimran S</creatorcontrib><creatorcontrib>Almeneisi, Hassan Mk</creatorcontrib><creatorcontrib>Bartlett, Heather L</creatorcontrib><creatorcontrib>Lindsay, Ian</creatorcontrib><creatorcontrib>Grewal, Jasmine</creatorcontrib><creatorcontrib>Nicolarsen, Jeremy</creatorcontrib><creatorcontrib>Araujo, John J</creatorcontrib><creatorcontrib>Cramer, Jonathan W</creatorcontrib><creatorcontrib>Bouchardy, Judith</creatorcontrib><creatorcontrib>Al Najashi, Khalid</creatorcontrib><creatorcontrib>Ryan, Kristi</creatorcontrib><creatorcontrib>Alshawabkeh, Laith</creatorcontrib><creatorcontrib>Andrade, Lauren</creatorcontrib><creatorcontrib>Ladouceur, Magalie</creatorcontrib><creatorcontrib>Schwerzmann, Markus</creatorcontrib><creatorcontrib>Greutmann, Matthias</creatorcontrib><creatorcontrib>Meras, Pablo</creatorcontrib><creatorcontrib>Ferrero, Paolo</creatorcontrib><creatorcontrib>Dehghani, Payam</creatorcontrib><creatorcontrib>Tung, Poyee P</creatorcontrib><creatorcontrib>Garcia-Orta, Rocio</creatorcontrib><creatorcontrib>Tompkins, Rose O</creatorcontrib><creatorcontrib>Gendi, Salwa M</creatorcontrib><creatorcontrib>Cohen, Scott</creatorcontrib><creatorcontrib>Klewer, Scott</creatorcontrib><creatorcontrib>Hascoet, Sebastien</creatorcontrib><creatorcontrib>Mohammadzadeh, Shabnam</creatorcontrib><creatorcontrib>Upadhyay, Shailendra</creatorcontrib><creatorcontrib>Fisher, Stacy D</creatorcontrib><creatorcontrib>Cook, Stephen</creatorcontrib><creatorcontrib>Cotts, Timothy B</creatorcontrib><creatorcontrib>Aboulhosn, Jamil A</creatorcontrib><title>COVID-19 in Adults With Congenital Heart Disease</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications.
This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes.
Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined.
From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not.
COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity.</description><subject>Adult</subject><subject>Cardiac Surgical Procedures - methods</subject><subject>Cardiac Surgical Procedures - statistics & numerical data</subject><subject>Causality</subject><subject>Comorbidity</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - therapy</subject><subject>COVID-19 Testing - methods</subject><subject>Cyanosis - diagnosis</subject><subject>Cyanosis - etiology</subject><subject>Cyanosis - mortality</subject><subject>Female</subject><subject>Global Health - statistics & numerical data</subject><subject>Heart Defects, Congenital - classification</subject><subject>Heart Defects, Congenital - epidemiology</subject><subject>Heart Defects, Congenital - physiopathology</subject><subject>Heart Defects, Congenital - therapy</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - mortality</subject><subject>Male</subject><subject>Mortality</subject><subject>Original Investigation</subject><subject>Patient Acuity</subject><subject>Risk Factors</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Symptom Assessment</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUNtKw0AQXUSxtfoDPkgefUmczWZvL0JJ1RYKffHyuGySTZuQJjWbCP6N3-KXuaG1KByYgZlz5sxB6BpDgAGzuzIodZoGIYQ4gNCBnKAxplT4hEp-isbACfUxSD5CF9aWAMAEludoRAiXFIgcIxyvXhczH0uvqL1p1led9d6KbuPFTb02ddHp6vtrbnTbebPCGm3NJTrLdWXN1aFO0Mvjw3M895erp0U8XfppBGHnY0EYjwSlhkWJwEkqGDeY5ClllCfGGec8D41kGcM0Z67LSO68u1nEJOVkgu73urs-2ZosNXXX6krt2mKr20_V6EL9n9TFRq2bDyWGNwGcwO1BoG3ee2M7tS1saqpK16bprQopCMoBC-FWw_1q2jbWtiY_nsGghqxVqYas1ZC1gtCBONLNX4NHym-45Adwz3qk</recordid><startdate>20210406</startdate><enddate>20210406</enddate><creator>Broberg, Craig S</creator><creator>Kovacs, Adrienne H</creator><creator>Sadeghi, Soraya</creator><creator>Rosenbaum, Marlon S</creator><creator>Lewis, Matthew J</creator><creator>Carazo, Matthew R</creator><creator>Rodriguez, 3rd, Fred H</creator><creator>Halpern, Dan G</creator><creator>Feinberg, Jodi</creator><creator>Galilea, Francisca Arancibia</creator><creator>Baraona, Fernando</creator><creator>Cedars, Ari M</creator><creator>Ko, Jong M</creator><creator>Porayette, Prashob</creator><creator>Maldonado, Jennifer</creator><creator>Sarubbi, Berardo</creator><creator>Fusco, Flavia</creator><creator>Frogoudaki, Alexandra A</creator><creator>Nir, Amiram</creator><creator>Chaudhry, Anisa</creator><creator>John, Anitha S</creator><creator>Karbassi, Arsha</creator><creator>Hoskoppal, Arvind K</creator><creator>Frischhertz, Benjamin P</creator><creator>Hendrickson, Benjamin</creator><creator>Bouma, Berto J</creator><creator>Rodriguez-Monserrate, Carla P</creator><creator>Broda, Christopher R</creator><creator>Tobler, Daniel</creator><creator>Gregg, David</creator><creator>Martinez-Quintana, Efren</creator><creator>Yeung, Elizabeth</creator><creator>Krieger, Eric V</creator><creator>Ruperti-Repilado, Francisco J</creator><creator>Giannakoulas, George</creator><creator>Lui, George K</creator><creator>Ephrem, Georges</creator><creator>Singh, Harsimran S</creator><creator>Almeneisi, Hassan Mk</creator><creator>Bartlett, Heather L</creator><creator>Lindsay, Ian</creator><creator>Grewal, Jasmine</creator><creator>Nicolarsen, Jeremy</creator><creator>Araujo, John J</creator><creator>Cramer, Jonathan W</creator><creator>Bouchardy, Judith</creator><creator>Al Najashi, Khalid</creator><creator>Ryan, Kristi</creator><creator>Alshawabkeh, Laith</creator><creator>Andrade, Lauren</creator><creator>Ladouceur, Magalie</creator><creator>Schwerzmann, Markus</creator><creator>Greutmann, Matthias</creator><creator>Meras, Pablo</creator><creator>Ferrero, Paolo</creator><creator>Dehghani, Payam</creator><creator>Tung, Poyee P</creator><creator>Garcia-Orta, Rocio</creator><creator>Tompkins, Rose O</creator><creator>Gendi, Salwa M</creator><creator>Cohen, Scott</creator><creator>Klewer, Scott</creator><creator>Hascoet, Sebastien</creator><creator>Mohammadzadeh, Shabnam</creator><creator>Upadhyay, Shailendra</creator><creator>Fisher, Stacy D</creator><creator>Cook, Stephen</creator><creator>Cotts, Timothy B</creator><creator>Aboulhosn, Jamil A</creator><general>by the American College of Cardiology Foundation. Published by Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210406</creationdate><title>COVID-19 in Adults With Congenital Heart Disease</title><author>Broberg, Craig S ; Kovacs, Adrienne H ; Sadeghi, Soraya ; Rosenbaum, Marlon S ; Lewis, Matthew J ; Carazo, Matthew R ; Rodriguez, 3rd, Fred H ; Halpern, Dan G ; Feinberg, Jodi ; Galilea, Francisca Arancibia ; Baraona, Fernando ; Cedars, Ari M ; Ko, Jong M ; Porayette, Prashob ; Maldonado, Jennifer ; Sarubbi, Berardo ; Fusco, Flavia ; Frogoudaki, Alexandra A ; Nir, Amiram ; Chaudhry, Anisa ; John, Anitha S ; Karbassi, Arsha ; Hoskoppal, Arvind K ; Frischhertz, Benjamin P ; Hendrickson, Benjamin ; Bouma, Berto J ; Rodriguez-Monserrate, Carla P ; Broda, Christopher R ; Tobler, Daniel ; Gregg, David ; Martinez-Quintana, Efren ; Yeung, Elizabeth ; Krieger, Eric V ; Ruperti-Repilado, Francisco J ; Giannakoulas, George ; Lui, George K ; Ephrem, Georges ; Singh, Harsimran S ; Almeneisi, Hassan Mk ; Bartlett, Heather L ; Lindsay, Ian ; Grewal, Jasmine ; Nicolarsen, Jeremy ; Araujo, John J ; Cramer, Jonathan W ; Bouchardy, Judith ; Al Najashi, Khalid ; Ryan, Kristi ; Alshawabkeh, Laith ; Andrade, Lauren ; Ladouceur, Magalie ; Schwerzmann, Markus ; Greutmann, Matthias ; Meras, Pablo ; Ferrero, Paolo ; Dehghani, Payam ; Tung, Poyee P ; Garcia-Orta, Rocio ; Tompkins, Rose O ; Gendi, Salwa M ; Cohen, Scott ; Klewer, Scott ; Hascoet, Sebastien ; Mohammadzadeh, Shabnam ; Upadhyay, Shailendra ; Fisher, Stacy D ; Cook, Stephen ; Cotts, Timothy B ; Aboulhosn, Jamil A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-183674855e64b81bc867e13fc5657beacc77f2e96d615f62e9d3f5587be469573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Cardiac Surgical Procedures - methods</topic><topic>Cardiac Surgical Procedures - statistics & numerical data</topic><topic>Causality</topic><topic>Comorbidity</topic><topic>COVID-19 - mortality</topic><topic>COVID-19 - therapy</topic><topic>COVID-19 Testing - methods</topic><topic>Cyanosis - diagnosis</topic><topic>Cyanosis - etiology</topic><topic>Cyanosis - mortality</topic><topic>Female</topic><topic>Global Health - statistics & numerical data</topic><topic>Heart Defects, Congenital - classification</topic><topic>Heart Defects, Congenital - epidemiology</topic><topic>Heart Defects, Congenital - physiopathology</topic><topic>Heart Defects, Congenital - therapy</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Hypertension, Pulmonary - mortality</topic><topic>Male</topic><topic>Mortality</topic><topic>Original Investigation</topic><topic>Patient Acuity</topic><topic>Risk Factors</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>Symptom Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broberg, Craig S</creatorcontrib><creatorcontrib>Kovacs, Adrienne H</creatorcontrib><creatorcontrib>Sadeghi, Soraya</creatorcontrib><creatorcontrib>Rosenbaum, Marlon S</creatorcontrib><creatorcontrib>Lewis, Matthew J</creatorcontrib><creatorcontrib>Carazo, Matthew R</creatorcontrib><creatorcontrib>Rodriguez, 3rd, Fred H</creatorcontrib><creatorcontrib>Halpern, Dan G</creatorcontrib><creatorcontrib>Feinberg, Jodi</creatorcontrib><creatorcontrib>Galilea, Francisca Arancibia</creatorcontrib><creatorcontrib>Baraona, Fernando</creatorcontrib><creatorcontrib>Cedars, Ari M</creatorcontrib><creatorcontrib>Ko, Jong M</creatorcontrib><creatorcontrib>Porayette, Prashob</creatorcontrib><creatorcontrib>Maldonado, Jennifer</creatorcontrib><creatorcontrib>Sarubbi, Berardo</creatorcontrib><creatorcontrib>Fusco, Flavia</creatorcontrib><creatorcontrib>Frogoudaki, Alexandra A</creatorcontrib><creatorcontrib>Nir, Amiram</creatorcontrib><creatorcontrib>Chaudhry, Anisa</creatorcontrib><creatorcontrib>John, Anitha S</creatorcontrib><creatorcontrib>Karbassi, Arsha</creatorcontrib><creatorcontrib>Hoskoppal, Arvind K</creatorcontrib><creatorcontrib>Frischhertz, Benjamin P</creatorcontrib><creatorcontrib>Hendrickson, Benjamin</creatorcontrib><creatorcontrib>Bouma, Berto J</creatorcontrib><creatorcontrib>Rodriguez-Monserrate, Carla P</creatorcontrib><creatorcontrib>Broda, Christopher R</creatorcontrib><creatorcontrib>Tobler, Daniel</creatorcontrib><creatorcontrib>Gregg, David</creatorcontrib><creatorcontrib>Martinez-Quintana, Efren</creatorcontrib><creatorcontrib>Yeung, Elizabeth</creatorcontrib><creatorcontrib>Krieger, Eric V</creatorcontrib><creatorcontrib>Ruperti-Repilado, Francisco J</creatorcontrib><creatorcontrib>Giannakoulas, George</creatorcontrib><creatorcontrib>Lui, George K</creatorcontrib><creatorcontrib>Ephrem, Georges</creatorcontrib><creatorcontrib>Singh, Harsimran S</creatorcontrib><creatorcontrib>Almeneisi, Hassan Mk</creatorcontrib><creatorcontrib>Bartlett, Heather L</creatorcontrib><creatorcontrib>Lindsay, Ian</creatorcontrib><creatorcontrib>Grewal, Jasmine</creatorcontrib><creatorcontrib>Nicolarsen, Jeremy</creatorcontrib><creatorcontrib>Araujo, John J</creatorcontrib><creatorcontrib>Cramer, Jonathan W</creatorcontrib><creatorcontrib>Bouchardy, Judith</creatorcontrib><creatorcontrib>Al Najashi, Khalid</creatorcontrib><creatorcontrib>Ryan, Kristi</creatorcontrib><creatorcontrib>Alshawabkeh, Laith</creatorcontrib><creatorcontrib>Andrade, Lauren</creatorcontrib><creatorcontrib>Ladouceur, Magalie</creatorcontrib><creatorcontrib>Schwerzmann, Markus</creatorcontrib><creatorcontrib>Greutmann, Matthias</creatorcontrib><creatorcontrib>Meras, Pablo</creatorcontrib><creatorcontrib>Ferrero, Paolo</creatorcontrib><creatorcontrib>Dehghani, Payam</creatorcontrib><creatorcontrib>Tung, Poyee P</creatorcontrib><creatorcontrib>Garcia-Orta, Rocio</creatorcontrib><creatorcontrib>Tompkins, Rose O</creatorcontrib><creatorcontrib>Gendi, Salwa M</creatorcontrib><creatorcontrib>Cohen, Scott</creatorcontrib><creatorcontrib>Klewer, Scott</creatorcontrib><creatorcontrib>Hascoet, Sebastien</creatorcontrib><creatorcontrib>Mohammadzadeh, Shabnam</creatorcontrib><creatorcontrib>Upadhyay, Shailendra</creatorcontrib><creatorcontrib>Fisher, Stacy D</creatorcontrib><creatorcontrib>Cook, Stephen</creatorcontrib><creatorcontrib>Cotts, Timothy B</creatorcontrib><creatorcontrib>Aboulhosn, Jamil A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broberg, Craig S</au><au>Kovacs, Adrienne H</au><au>Sadeghi, Soraya</au><au>Rosenbaum, Marlon S</au><au>Lewis, Matthew J</au><au>Carazo, Matthew R</au><au>Rodriguez, 3rd, Fred H</au><au>Halpern, Dan G</au><au>Feinberg, Jodi</au><au>Galilea, Francisca Arancibia</au><au>Baraona, Fernando</au><au>Cedars, Ari M</au><au>Ko, Jong M</au><au>Porayette, Prashob</au><au>Maldonado, Jennifer</au><au>Sarubbi, Berardo</au><au>Fusco, Flavia</au><au>Frogoudaki, Alexandra A</au><au>Nir, Amiram</au><au>Chaudhry, Anisa</au><au>John, Anitha S</au><au>Karbassi, Arsha</au><au>Hoskoppal, Arvind K</au><au>Frischhertz, Benjamin P</au><au>Hendrickson, Benjamin</au><au>Bouma, Berto J</au><au>Rodriguez-Monserrate, Carla P</au><au>Broda, Christopher R</au><au>Tobler, Daniel</au><au>Gregg, David</au><au>Martinez-Quintana, Efren</au><au>Yeung, Elizabeth</au><au>Krieger, Eric V</au><au>Ruperti-Repilado, Francisco J</au><au>Giannakoulas, George</au><au>Lui, George K</au><au>Ephrem, Georges</au><au>Singh, Harsimran S</au><au>Almeneisi, Hassan Mk</au><au>Bartlett, Heather L</au><au>Lindsay, Ian</au><au>Grewal, Jasmine</au><au>Nicolarsen, Jeremy</au><au>Araujo, John J</au><au>Cramer, Jonathan W</au><au>Bouchardy, Judith</au><au>Al Najashi, Khalid</au><au>Ryan, Kristi</au><au>Alshawabkeh, Laith</au><au>Andrade, Lauren</au><au>Ladouceur, Magalie</au><au>Schwerzmann, Markus</au><au>Greutmann, Matthias</au><au>Meras, Pablo</au><au>Ferrero, Paolo</au><au>Dehghani, Payam</au><au>Tung, Poyee P</au><au>Garcia-Orta, Rocio</au><au>Tompkins, Rose O</au><au>Gendi, Salwa M</au><au>Cohen, Scott</au><au>Klewer, Scott</au><au>Hascoet, Sebastien</au><au>Mohammadzadeh, Shabnam</au><au>Upadhyay, Shailendra</au><au>Fisher, Stacy D</au><au>Cook, Stephen</au><au>Cotts, Timothy B</au><au>Aboulhosn, Jamil A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19 in Adults With Congenital Heart Disease</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2021-04-06</date><risdate>2021</risdate><volume>77</volume><issue>13</issue><spage>1644</spage><epage>1655</epage><pages>1644-1655</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications.
This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes.
Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined.
From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not.
COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity.</abstract><cop>United States</cop><pub>by the American College of Cardiology Foundation. Published by Elsevier</pub><pmid>33795039</pmid><doi>10.1016/j.jacc.2021.02.023</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2021-04, Vol.77 (13), p.1644-1655 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8006800 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Cardiac Surgical Procedures - methods Cardiac Surgical Procedures - statistics & numerical data Causality Comorbidity COVID-19 - mortality COVID-19 - therapy COVID-19 Testing - methods Cyanosis - diagnosis Cyanosis - etiology Cyanosis - mortality Female Global Health - statistics & numerical data Heart Defects, Congenital - classification Heart Defects, Congenital - epidemiology Heart Defects, Congenital - physiopathology Heart Defects, Congenital - therapy Hospitalization - statistics & numerical data Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - etiology Hypertension, Pulmonary - mortality Male Mortality Original Investigation Patient Acuity Risk Factors SARS-CoV-2 - isolation & purification Symptom Assessment |
| title | COVID-19 in Adults With Congenital Heart Disease |
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