The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices

The invasion of glioblastoma is a complex process based on the interactions of tumor cells and the extracellular matrix. Tumors that are engineered using biomaterials are more physiologically relevant than a two‐dimensional (2D) cell culture system. Matrix metalloproteinases and the plasminogen acti...

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Veröffentlicht in:	Journal of cellular physiology 2019-04, Vol.234 (4), p.3948-3960
Hauptverfasser:	Kaphle, Pranita, Li, Yongchao, Yao, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Biomaterials Biomedical materials Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cell adhesion & migration Cell culture Cell Culture Techniques Cell Line, Tumor Cell migration Cell Movement - drug effects Collagen Collagen (type I) Collagen - metabolism Crosslinking Extracellular matrix Gene expression Gene Expression Regulation, Neoplastic Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioma Glioma cells Humans hydrogel Hydrogels inhibition Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism migration Neoplasm Invasiveness Pharmacology Protease Inhibitors - pharmacology Signal Transduction Stress, Mechanical t-Plasminogen activator Time Factors Tissue Plasminogen Activator - antagonists & inhibitors Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism Tumor cells Tumors U-Plasminogen activator Urokinase Viscosity
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