Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system

Targeting the thioredoxin/thioredoxin reductase (Trx/TrxR) system is a promising strategy to overcome cancer resistance to conventional therapy. The present study investigated the effect of curcumin on the Trx/TrxR system either alone or in combination with chemotherapy, or radiotherapy in human MCF...

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Veröffentlicht in:	Experimental and therapeutic medicine 2021-05, Vol.21 (5), p.506-506, Article 506
Hauptverfasser:	El Feky, Shaymaa Essam, Ghany Megahed, Magda Abdel, Abd El Moneim, Nadia Ahmed, Zaher, Ebtsam Rizq, Khamis, Shadwa Ahmed, Ali, Lamiaa Mohamed Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Antioxidants Apoptosis Breast cancer Cancer Cancer therapies Care and treatment Cell culture Chemotherapy Cytotoxicity Drug sensitization Gene expression Health aspects Methods Pharmacology, Experimental Proteins Radiation therapy Radiotherapy Spheroids Thioredoxin Turmeric
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