FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma

The PAX3-FOXO1 fusion protein is the key oncogenic driver in fusion positive rhabdomyosarcoma (FP-RMS), an aggressive soft tissue malignancy with a particularly poor prognosis. Identifying key downstream targets of PAX3-FOXO1 will provide new therapeutic opportunities for treatment of FP-RMS. Herein...

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Veröffentlicht in:	Oncogene 2021-03, Vol.40 (12), p.2182-2199
Hauptverfasser:	Milewski, David, Shukla, Samriddhi, Gryder, Berkley E., Pradhan, Arun, Donovan, Johnny, Sudha, Parvathi, Vallabh, Sushmitha, Pyros, Athena, Xu, Yan, Barski, Artem, Szabo, Sara, Turpin, Brian, Pressey, Joseph G., Millay, Douglas P., Khan, Javed, Kalinichenko, Vladimir V., Kalin, Tanya V.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/44 13/51 14/19 38/109 38/91 42/41 631/337/572 631/67/1798 64/60 Apoptosis Carcinogenesis - genetics Cell Biology Cell Line, Tumor Chromatin CRISPR Development and progression Enhancers Forkhead Box Protein O1 - genetics Forkhead protein Forkhead Transcription Factors - genetics Foxf1 gene FOXO1 protein Fusion protein Gene expression Gene Expression Regulation, Neoplastic - genetics Genetic aspects Human Genetics Humans Internal Medicine Malignancy Medicine Medicine & Public Health Muscle Development - genetics Myoblasts MyoD Protein - genetics Myogenin - genetics Oncology Overexpression Pax3 protein PAX3 Transcription Factor - genetics Rhabdomyosarcoma Rhabdomyosarcoma - genetics Rhabdomyosarcoma - pathology Transcription factors Tumor cells Tumorigenesis
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