Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms

Glioblastoma (GBM) is a lethal form of primary brain tumor in human adults. The impact of tumor-intrinsic alterations is not exclusively confined to cancer cells but can also be extended to the tumor microenvironment (TME). Glioblastoma-associated macrophages/microglia (GAMs) are a prominent type of...

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Veröffentlicht in:	Trends in immunology 2021-04, Vol.42 (4), p.280-292
Hauptverfasser:	Xuan, Wenjing, Lesniak, Maciej S., James, Charles David, Heimberger, Amy B., Chen, Peiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Biology Brain cancer Brain Neoplasms - genetics Brain tumors Cell growth Chemokines Context crosstalk Genes Genomics Glioblastoma Glioblastoma - genetics heterogeneity Humans Immune system Kinases Ligands Macrophages Microglia Mutation Patients Symbiosis Tumor Microenvironment Tumorigenesis Tumors
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