The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders
•We examined conduct disorder and ADHD genotypes in relation to marijuana disorders.•We examined genotypes with parental monitoring and community disadvantage.•An interaction between the conduct disorder genotype and disadvantage was observed.•Implications of the study findings are discussed. Extern...
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| Veröffentlicht in: | Drug and alcohol dependence 2018-10, Vol.191, p.365-373 |
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| creator | Rabinowitz, Jill A. Musci, Rashelle J. Milam, Adam J. Benke, Kelly Uhl, George R. Sisto, Danielle Y. Ialongo, Nicholas S. Maher, Brion S. |
| description | •We examined conduct disorder and ADHD genotypes in relation to marijuana disorders.•We examined genotypes with parental monitoring and community disadvantage.•An interaction between the conduct disorder genotype and disadvantage was observed.•Implications of the study findings are discussed.
Externalizing disorders have been extensively linked to substance use problems. However, less is known about whether genetic factors underpinning externalizing disorders and environmental features interact to predict substance use disorders (i.e., marijuana abuse and dependence) among urban African Americans. We examined whether polygenic risk scores (PRS) for conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD) interacted with contextual factors (i.e., parental monitoring, community disadvantage) to influence risk for marijuana use disorders in a sample of African American youth. Participants (N=1,050; 44.2% male) were initially recruited for an elementary school-based universal prevention trial in a Mid-Atlantic city and followed through age 20. Participants reported on their parental monitoring in sixth grade and whether they were diagnosed with marijuana abuse or dependence at age 20. Blood or saliva samples were genotyped using the Affymetrix 6.0 microarrays. The CD and ADHD PRS were created based on genome-wide association studies conducted by Dick et al. (2010) and Demontis et al. (2017), respectively. Community disadvantage was calculated based on census data when participants were in sixth grade. There was an interaction between the CD PRS and community disadvantage such that a higher CD PRS was associated with greater risk for a marijuana use disorder at higher levels of neighborhood disadvantage. This finding should be interpreted with caution owing to the number of significance tests performed. Implications for etiological models and future research directions are presented. |
| doi_str_mv | 10.1016/j.drugalcdep.2018.07.016 |
| format | Article |
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Externalizing disorders have been extensively linked to substance use problems. However, less is known about whether genetic factors underpinning externalizing disorders and environmental features interact to predict substance use disorders (i.e., marijuana abuse and dependence) among urban African Americans. We examined whether polygenic risk scores (PRS) for conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD) interacted with contextual factors (i.e., parental monitoring, community disadvantage) to influence risk for marijuana use disorders in a sample of African American youth. Participants (N=1,050; 44.2% male) were initially recruited for an elementary school-based universal prevention trial in a Mid-Atlantic city and followed through age 20. Participants reported on their parental monitoring in sixth grade and whether they were diagnosed with marijuana abuse or dependence at age 20. Blood or saliva samples were genotyped using the Affymetrix 6.0 microarrays. The CD and ADHD PRS were created based on genome-wide association studies conducted by Dick et al. (2010) and Demontis et al. (2017), respectively. Community disadvantage was calculated based on census data when participants were in sixth grade. There was an interaction between the CD PRS and community disadvantage such that a higher CD PRS was associated with greater risk for a marijuana use disorder at higher levels of neighborhood disadvantage. This finding should be interpreted with caution owing to the number of significance tests performed. Implications for etiological models and future research directions are presented.</description><identifier>ISSN: 0376-8716</identifier><identifier>ISSN: 1879-0046</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2018.07.016</identifier><identifier>PMID: 30195949</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adolescent ; African Americans ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention Deficit Disorder with Hyperactivity - psychology ; Attention deficit hyperactivity disorder ; Attention-deficit hyperactivity disorder polygenic risk score ; Blood ; Cannabis ; Censuses ; Child ; Communities ; Community ; Community disadvantage ; Comorbidity ; Conduct disorder ; Conduct Disorder - epidemiology ; Conduct Disorder - genetics ; Conduct Disorder - psychology ; Conduct disorder polygenic risk score ; Dependence ; Disease Susceptibility - epidemiology ; Disease Susceptibility - psychology ; Disorders ; Drug abuse ; Drug addiction ; Etiology ; Externalizing problems ; Female ; Genetic factors ; Genome-wide association studies ; Genome-Wide Association Study - methods ; Genomes ; Genomics ; Humans ; Hyperactivity ; Male ; Marijuana ; Marijuana Abuse - epidemiology ; Marijuana Abuse - genetics ; Marijuana Abuse - psychology ; Marijuana abuse and dependence ; Marijuana Use - epidemiology ; Marijuana Use - genetics ; Marijuana Use - psychology ; Medical disorders ; Minority & ethnic groups ; Monitoring ; Multifactorial Inheritance - genetics ; Neighborhoods ; Parental monitoring ; Parents & parenting ; Risk factors ; Saliva ; Statistical significance ; Substance use ; Substance use disorder ; Young Adult ; Youth</subject><ispartof>Drug and alcohol dependence, 2018-10, Vol.191, p.365-373</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Oct 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-c3ad15c23c7804708c2dfe8953d42629d164fbe9448d381244485d6d3deb64fc3</citedby><cites>FETCH-LOGICAL-c507t-c3ad15c23c7804708c2dfe8953d42629d164fbe9448d381244485d6d3deb64fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drugalcdep.2018.07.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,30999,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30195949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabinowitz, Jill A.</creatorcontrib><creatorcontrib>Musci, Rashelle J.</creatorcontrib><creatorcontrib>Milam, Adam J.</creatorcontrib><creatorcontrib>Benke, Kelly</creatorcontrib><creatorcontrib>Uhl, George R.</creatorcontrib><creatorcontrib>Sisto, Danielle Y.</creatorcontrib><creatorcontrib>Ialongo, Nicholas S.</creatorcontrib><creatorcontrib>Maher, Brion S.</creatorcontrib><title>The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>•We examined conduct disorder and ADHD genotypes in relation to marijuana disorders.•We examined genotypes with parental monitoring and community disadvantage.•An interaction between the conduct disorder genotype and disadvantage was observed.•Implications of the study findings are discussed.
Externalizing disorders have been extensively linked to substance use problems. However, less is known about whether genetic factors underpinning externalizing disorders and environmental features interact to predict substance use disorders (i.e., marijuana abuse and dependence) among urban African Americans. We examined whether polygenic risk scores (PRS) for conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD) interacted with contextual factors (i.e., parental monitoring, community disadvantage) to influence risk for marijuana use disorders in a sample of African American youth. Participants (N=1,050; 44.2% male) were initially recruited for an elementary school-based universal prevention trial in a Mid-Atlantic city and followed through age 20. Participants reported on their parental monitoring in sixth grade and whether they were diagnosed with marijuana abuse or dependence at age 20. Blood or saliva samples were genotyped using the Affymetrix 6.0 microarrays. The CD and ADHD PRS were created based on genome-wide association studies conducted by Dick et al. (2010) and Demontis et al. (2017), respectively. Community disadvantage was calculated based on census data when participants were in sixth grade. There was an interaction between the CD PRS and community disadvantage such that a higher CD PRS was associated with greater risk for a marijuana use disorder at higher levels of neighborhood disadvantage. This finding should be interpreted with caution owing to the number of significance tests performed. Implications for etiological models and future research directions are presented.</description><subject>Adolescent</subject><subject>African Americans</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention Deficit Disorder with Hyperactivity - psychology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Attention-deficit hyperactivity disorder polygenic risk score</subject><subject>Blood</subject><subject>Cannabis</subject><subject>Censuses</subject><subject>Child</subject><subject>Communities</subject><subject>Community</subject><subject>Community disadvantage</subject><subject>Comorbidity</subject><subject>Conduct disorder</subject><subject>Conduct Disorder - epidemiology</subject><subject>Conduct Disorder - genetics</subject><subject>Conduct Disorder - psychology</subject><subject>Conduct disorder polygenic risk score</subject><subject>Dependence</subject><subject>Disease Susceptibility - epidemiology</subject><subject>Disease Susceptibility - psychology</subject><subject>Disorders</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Etiology</subject><subject>Externalizing problems</subject><subject>Female</subject><subject>Genetic factors</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Male</subject><subject>Marijuana</subject><subject>Marijuana Abuse - epidemiology</subject><subject>Marijuana Abuse - genetics</subject><subject>Marijuana Abuse - psychology</subject><subject>Marijuana abuse and dependence</subject><subject>Marijuana Use - epidemiology</subject><subject>Marijuana Use - genetics</subject><subject>Marijuana Use - psychology</subject><subject>Medical disorders</subject><subject>Minority & ethnic groups</subject><subject>Monitoring</subject><subject>Multifactorial Inheritance - genetics</subject><subject>Neighborhoods</subject><subject>Parental monitoring</subject><subject>Parents & parenting</subject><subject>Risk factors</subject><subject>Saliva</subject><subject>Statistical significance</subject><subject>Substance use</subject><subject>Substance use disorder</subject><subject>Young Adult</subject><subject>Youth</subject><issn>0376-8716</issn><issn>1879-0046</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkcuOFCEUhonROO3oKxgSN26qhLpw2ZjoxFsyiZtxTWg41UNJQwlV7bRP4GNLpccZdSMJgfB_5-fAjxCmpKaEsldjbdOy095YmOqGUFETXhfhAdpQwWVFSMceog1pOasEp-wMPcl5JGUwSR6js5ZQ2ctObtDPq2vALsyQJq-PeAvzd4CA4aacBO3dDxd22Lock4WU8RT9cQfBGZxc_oqziQky1sFiE4vJzbxojwdt5ljgGPBc3C0cwMdpD2HGccB7ndy46KDxkuHe-il6NGif4dnteo6-vH93dfGxuvz84dPFm8vK9ITPlWm1pb1pWsMF6TgRprEDCNm3tmtYIy1l3bAF2XXCtoI2Xdn0ltnWwrYopj1Hr0--07LdgzWlq6S9mpIrjR1V1E79rQR3rXbxoAQhfcP6YvDy1iDFbwvkWe1dNuC9DhCXrJqSkGxayXlBX_yDjnFZv3WlSmuszJUSJ8qkmHOC4a4ZStQatxrVfdxqjVsRropQSp__-Zi7wt_5FuDtCYDypQcHSWXjIBiwLoGZlY3u_7f8AhFSxVY</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Rabinowitz, Jill A.</creator><creator>Musci, Rashelle J.</creator><creator>Milam, Adam J.</creator><creator>Benke, Kelly</creator><creator>Uhl, George R.</creator><creator>Sisto, Danielle Y.</creator><creator>Ialongo, Nicholas S.</creator><creator>Maher, Brion S.</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders</title><author>Rabinowitz, Jill A. ; 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Externalizing disorders have been extensively linked to substance use problems. However, less is known about whether genetic factors underpinning externalizing disorders and environmental features interact to predict substance use disorders (i.e., marijuana abuse and dependence) among urban African Americans. We examined whether polygenic risk scores (PRS) for conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD) interacted with contextual factors (i.e., parental monitoring, community disadvantage) to influence risk for marijuana use disorders in a sample of African American youth. Participants (N=1,050; 44.2% male) were initially recruited for an elementary school-based universal prevention trial in a Mid-Atlantic city and followed through age 20. Participants reported on their parental monitoring in sixth grade and whether they were diagnosed with marijuana abuse or dependence at age 20. Blood or saliva samples were genotyped using the Affymetrix 6.0 microarrays. The CD and ADHD PRS were created based on genome-wide association studies conducted by Dick et al. (2010) and Demontis et al. (2017), respectively. Community disadvantage was calculated based on census data when participants were in sixth grade. There was an interaction between the CD PRS and community disadvantage such that a higher CD PRS was associated with greater risk for a marijuana use disorder at higher levels of neighborhood disadvantage. This finding should be interpreted with caution owing to the number of significance tests performed. Implications for etiological models and future research directions are presented.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30195949</pmid><doi>10.1016/j.drugalcdep.2018.07.016</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent African Americans Attention Deficit Disorder with Hyperactivity - epidemiology Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - psychology Attention deficit hyperactivity disorder Attention-deficit hyperactivity disorder polygenic risk score Blood Cannabis Censuses Child Communities Community Community disadvantage Comorbidity Conduct disorder Conduct Disorder - epidemiology Conduct Disorder - genetics Conduct Disorder - psychology Conduct disorder polygenic risk score Dependence Disease Susceptibility - epidemiology Disease Susceptibility - psychology Disorders Drug abuse Drug addiction Etiology Externalizing problems Female Genetic factors Genome-wide association studies Genome-Wide Association Study - methods Genomes Genomics Humans Hyperactivity Male Marijuana Marijuana Abuse - epidemiology Marijuana Abuse - genetics Marijuana Abuse - psychology Marijuana abuse and dependence Marijuana Use - epidemiology Marijuana Use - genetics Marijuana Use - psychology Medical disorders Minority & ethnic groups Monitoring Multifactorial Inheritance - genetics Neighborhoods Parental monitoring Parents & parenting Risk factors Saliva Statistical significance Substance use Substance use disorder Young Adult Youth |
| title | The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders |
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