AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal

Previously, we have shown that Tfap2b, the gene encoding transcription factor AP-2β, is needed for normal mouse eye development. Specifically, targeted loss of Tfap2b in neural crest cells (NCCs)1 and their derivatives, particularly the periocular mesenchyme (POM), resulted in anterior segment defec...

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Veröffentlicht in:	Experimental eye research 2020-06, Vol.195, p.108042-108042, Article 108042
Hauptverfasser:	Akula, Monica, Taiyab, Aftab, Deschamps, Paula, Yee, Shannin, Ball, Alexander K., Williams, Trevor, West-Mays, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Development Gene Expression Regulation, Developmental Immunohistochemistry Intraocular Pressure - physiology Knockout mouse Mice Mice, Knockout Models, Animal Neural crest Periocular mesenchyme Reporter mouse RNA - genetics RNA - metabolism Schlemm's canal Trabecular meshwork Trabecular Meshwork - growth & development Trabecular Meshwork - metabolism Transcription Factor AP-2 - genetics Transcription Factor AP-2 - metabolism
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