Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects

Cell therapies for autoimmune diseases using tolerogenic dendritic cells (tolDC) have been promisingly explored. A major stumbling block has been generating stable tolDC, with low risk of converting to mature immunogenic DC (mDC), exacerbating disease. mDC induction involves a metabolic shift to lac...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-03, Vol.78 (6), p.2857-2876
Hauptverfasser:	Christofi, M., Le Sommer, S., Mölzer, C., Klaska, I. P., Kuffova, L., Forrester, J. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antigens Antigens, Bacterial - immunology Autografts Autoimmune diseases Autoimmune Diseases - drug therapy B7-2 Antigen - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - cytology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - metabolism CD40 antigen CD86 antigen Cell Biology Cell proliferation Cell Proliferation - drug effects Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Deoxyglucose - pharmacology Deoxyglucose - therapeutic use Dosage Energy sources Experimental autoimmune uveoretinitis Glucose Glycolysis Glycolysis - drug effects Histocompatibility Antigens Class II - metabolism Immune checkpoint Immunogenicity Immunosuppressive agents Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Interleukin 10 Interleukin 12 Interleukin-10 - metabolism Kinases Lactic acid Lactic Acid - metabolism Life Sciences Lymphocytes Lymphocytes T Major histocompatibility complex Mice Mice, Inbred C57BL Original Original Article Oxidation Oxidative phosphorylation Oxidative Phosphorylation - drug effects Phenotypes Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Signal transduction Signal Transduction - drug effects
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