(Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability
Sperm fertility ability may be modulated by different molecular systems, such as the renin-angiotensin system (RAS). Although renin is one of its most relevant peptides, the presence and role of the (pro)renin receptor (PRR) is completely unknown. We have proved for the first time the existence of P...
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| Veröffentlicht in: | International journal of molecular sciences 2021-03, Vol.22 (6), p.3215 |
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| creator | Gianzo, Marta Urizar-Arenaza, Itziar Muñoa-Hoyos, Iraia Larreategui, Zaloa Garrido, Nicolás Irazusta, Jon Subirán, Nerea |
| description | Sperm fertility ability may be modulated by different molecular systems, such as the renin-angiotensin system (RAS). Although renin is one of its most relevant peptides, the presence and role of the (pro)renin receptor (PRR) is completely unknown. We have proved for the first time the existence of PRR and its transcript in human sperm by western blot and RT-PCR. Immunofluorescence studies showed that this receptor is mainly located in the apical region over the acrosome and in the postacrosomal region of the sperm head and along the sperm tail. In addition, this prospective cohort study also proves that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility, worse blastocyst development and no-viable blastocysts. Our results provide insight into how PRR play a negative role in sperm physiology that it may condition human embryo quality and development. An in-depth understanding of the role of PRR in sperm fertility can help elucidate its role in male infertility, as well as establish biomarkers for the diagnosis or selection of sperm to use during assisted reproductive techniques. |
| doi_str_mv | 10.3390/ijms22063215 |
| format | Article |
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Although renin is one of its most relevant peptides, the presence and role of the (pro)renin receptor (PRR) is completely unknown. We have proved for the first time the existence of PRR and its transcript in human sperm by western blot and RT-PCR. Immunofluorescence studies showed that this receptor is mainly located in the apical region over the acrosome and in the postacrosomal region of the sperm head and along the sperm tail. In addition, this prospective cohort study also proves that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility, worse blastocyst development and no-viable blastocysts. Our results provide insight into how PRR play a negative role in sperm physiology that it may condition human embryo quality and development. An in-depth understanding of the role of PRR in sperm fertility can help elucidate its role in male infertility, as well as establish biomarkers for the diagnosis or selection of sperm to use during assisted reproductive techniques.</description><identifier>ISSN: 1422-0067</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22063215</identifier><identifier>PMID: 33809946</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Embryo Transfer ; Embryonic Development - genetics ; Female ; Fertilization in Vitro ; Gene Expression ; Humans ; Infertility, Male - genetics ; Live Birth ; Male ; Pregnancy ; Pregnancy Outcome ; Protein Transport ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Semen Analysis ; Spermatozoa - metabolism ; Vacuolar Proton-Translocating ATPases - genetics ; Vacuolar Proton-Translocating ATPases - metabolism</subject><ispartof>International journal of molecular sciences, 2021-03, Vol.22 (6), p.3215</ispartof><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-1bfb26b4925ada1023f4257b207eaa9bcafabe758dad1aee9c9500052576e94d3</citedby><cites>FETCH-LOGICAL-c384t-1bfb26b4925ada1023f4257b207eaa9bcafabe758dad1aee9c9500052576e94d3</cites><orcidid>0000-0003-2351-4955 ; 0000-0002-6763-8602</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33809946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gianzo, Marta</creatorcontrib><creatorcontrib>Urizar-Arenaza, Itziar</creatorcontrib><creatorcontrib>Muñoa-Hoyos, Iraia</creatorcontrib><creatorcontrib>Larreategui, Zaloa</creatorcontrib><creatorcontrib>Garrido, Nicolás</creatorcontrib><creatorcontrib>Irazusta, Jon</creatorcontrib><creatorcontrib>Subirán, Nerea</creatorcontrib><title>(Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Sperm fertility ability may be modulated by different molecular systems, such as the renin-angiotensin system (RAS). Although renin is one of its most relevant peptides, the presence and role of the (pro)renin receptor (PRR) is completely unknown. We have proved for the first time the existence of PRR and its transcript in human sperm by western blot and RT-PCR. Immunofluorescence studies showed that this receptor is mainly located in the apical region over the acrosome and in the postacrosomal region of the sperm head and along the sperm tail. In addition, this prospective cohort study also proves that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility, worse blastocyst development and no-viable blastocysts. Our results provide insight into how PRR play a negative role in sperm physiology that it may condition human embryo quality and development. An in-depth understanding of the role of PRR in sperm fertility can help elucidate its role in male infertility, as well as establish biomarkers for the diagnosis or selection of sperm to use during assisted reproductive techniques.</description><subject>Embryo Transfer</subject><subject>Embryonic Development - genetics</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Infertility, Male - genetics</subject><subject>Live Birth</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Protein Transport</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Semen Analysis</subject><subject>Spermatozoa - metabolism</subject><subject>Vacuolar Proton-Translocating ATPases - genetics</subject><subject>Vacuolar Proton-Translocating ATPases - metabolism</subject><issn>1422-0067</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLw0AUhQdRbK3uXMssKxidzCPJbIRSrC0ULD62DpPJjabkUWcmhf57o62lru7lno9zDxyELkNyy5gkd8WycpSSiNFQHKF-yCkNCIni44O9h86cWxJCGRXyFPUYS4iUPOqj9-HCNtcW6qLGz2Bg5RuLZw4vLDioPe7O07bSNX5Zga2wrjM883iUrcE6KDd4lOdgvNvJE7C-KAvf3dPfeY5Ocl06uNjNAXqbPLyOp8H86XE2Hs0DwxLugzDNUxqlXFKhMx12OXNORZxSEoPWMjU61ynEIsl0FmoAaaQghIiOiUDyjA3Q_dZ31aYVZKaLbnWpVraotN2oRhfqv1IXn-qjWauEEB5K1hkMdwa2-WrBeVUVzkBZ6hqa1ikqSCJiGnPRoTdb1NjGOQv5_k1I1E8l6rCSDr86jLaH_zpg3yePiPI</recordid><startdate>20210322</startdate><enddate>20210322</enddate><creator>Gianzo, Marta</creator><creator>Urizar-Arenaza, Itziar</creator><creator>Muñoa-Hoyos, Iraia</creator><creator>Larreategui, Zaloa</creator><creator>Garrido, Nicolás</creator><creator>Irazusta, Jon</creator><creator>Subirán, Nerea</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2351-4955</orcidid><orcidid>https://orcid.org/0000-0002-6763-8602</orcidid></search><sort><creationdate>20210322</creationdate><title>(Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability</title><author>Gianzo, Marta ; 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Embryo Transfer Embryonic Development - genetics Female Fertilization in Vitro Gene Expression Humans Infertility, Male - genetics Live Birth Male Pregnancy Pregnancy Outcome Protein Transport Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Semen Analysis Spermatozoa - metabolism Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism |
| title | (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability |
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