The PARP Way to Epigenetic Changes
ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from "nicotinamide adenine dinucleotide-donor molecules" to their target sub...
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| Veröffentlicht in: | Genes 2021-03, Vol.12 (3), p.446 |
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| creator | Ummarino, Simone Hausman, Clinton Di Ruscio, Annalisa |
| description | ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from "nicotinamide adenine dinucleotide-donor molecules" to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond. |
| doi_str_mv | 10.3390/genes12030446 |
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Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from "nicotinamide adenine dinucleotide-donor molecules" to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes12030446</identifier><identifier>PMID: 33804735</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Chromatin Assembly and Disassembly ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Neoplasms - drug therapy ; Neoplasms - genetics ; Neoplasms - metabolism ; Poly (ADP-Ribose) Polymerase-1 - drug effects ; Poly (ADP-Ribose) Polymerase-1 - metabolism ; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use ; Poly(ADP-ribose) Polymerases - metabolism ; Protein Processing, Post-Translational ; Review</subject><ispartof>Genes, 2021-03, Vol.12 (3), p.446</ispartof><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-2b953248b34d7be3eb8af5d377f8e6ec9b0431437e62743c7ba012f0ce7f71133</citedby><cites>FETCH-LOGICAL-c387t-2b953248b34d7be3eb8af5d377f8e6ec9b0431437e62743c7ba012f0ce7f71133</cites><orcidid>0000-0001-6009-3892 ; 0000-0002-9705-4245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003872/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003872/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33804735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ummarino, Simone</creatorcontrib><creatorcontrib>Hausman, Clinton</creatorcontrib><creatorcontrib>Di Ruscio, Annalisa</creatorcontrib><title>The PARP Way to Epigenetic Changes</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from "nicotinamide adenine dinucleotide-donor molecules" to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond.</description><subject>Chromatin Assembly and Disassembly</subject><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Poly (ADP-Ribose) Polymerase-1 - drug effects</subject><subject>Poly (ADP-Ribose) Polymerase-1 - metabolism</subject><subject>Poly(ADP-ribose) Polymerase Inhibitors - pharmacology</subject><subject>Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Protein Processing, Post-Translational</subject><subject>Review</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbKk9epXgyUt0dmc3m16EUuoHFCxS8bjsbidtJE1qNhX6701pLXYuMzAPzwwvY9cc7hEH8LCgkgIXgCBlcsa6AjTGUgp1_m_usH4IX9CWBAGgLlkHMQWpUXXZ7WxJ0XT4Po0-7TZqqmi8znfWJvfRaGnLBYUrdpHZIlD_0Hvs42k8G73Ek7fn19FwEntMdRMLN1AoZOpQzrUjJJfaTM1R6yylhPzAgUQuUVMitESvnQUuMvCkM805Yo897r3rjVvR3FPZ1LYw6zpf2XprKpub002ZL82i-jEpQPuBaAV3B0FdfW8oNGaVB09FYUuqNsEIBalKpELeovEe9XUVQk3Z8QwHs4vWnETb8jf_fzvSf0HiLzYIcvg</recordid><startdate>20210320</startdate><enddate>20210320</enddate><creator>Ummarino, Simone</creator><creator>Hausman, Clinton</creator><creator>Di Ruscio, Annalisa</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6009-3892</orcidid><orcidid>https://orcid.org/0000-0002-9705-4245</orcidid></search><sort><creationdate>20210320</creationdate><title>The PARP Way to Epigenetic Changes</title><author>Ummarino, Simone ; Hausman, Clinton ; Di Ruscio, Annalisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-2b953248b34d7be3eb8af5d377f8e6ec9b0431437e62743c7ba012f0ce7f71133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chromatin Assembly and Disassembly</topic><topic>DNA Methylation</topic><topic>Epigenesis, Genetic</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Poly (ADP-Ribose) Polymerase-1 - drug effects</topic><topic>Poly (ADP-Ribose) Polymerase-1 - metabolism</topic><topic>Poly(ADP-ribose) Polymerase Inhibitors - pharmacology</topic><topic>Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Protein Processing, Post-Translational</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ummarino, Simone</creatorcontrib><creatorcontrib>Hausman, Clinton</creatorcontrib><creatorcontrib>Di Ruscio, Annalisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ummarino, Simone</au><au>Hausman, Clinton</au><au>Di Ruscio, Annalisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The PARP Way to Epigenetic Changes</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2021-03-20</date><risdate>2021</risdate><volume>12</volume><issue>3</issue><spage>446</spage><pages>446-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from "nicotinamide adenine dinucleotide-donor molecules" to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>33804735</pmid><doi>10.3390/genes12030446</doi><orcidid>https://orcid.org/0000-0001-6009-3892</orcidid><orcidid>https://orcid.org/0000-0002-9705-4245</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Chromatin Assembly and Disassembly DNA Methylation Epigenesis, Genetic Humans Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Poly (ADP-Ribose) Polymerase-1 - drug effects Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use Poly(ADP-ribose) Polymerases - metabolism Protein Processing, Post-Translational Review |
| title | The PARP Way to Epigenetic Changes |
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