Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee

Osteoarthritis (OA) is a multifactorial disease which is characterized by a change in the homeostasis of the extracellular matrix (ECM). The ECM is essential for the function of the articular cartilage and plays an important role in cartilage mechanotransduction. To provide a better understanding of...

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Veröffentlicht in:	International journal of molecular sciences 2021-03, Vol.22 (6), p.3073
Hauptverfasser:	Mählich, Daniela, Glasmacher, Anne, Müller, Ilka, Oppermann, Johannes, Grevenstein, David, Eysel, Peer, Heilig, Juliane, Wirth, Brunhilde, Zaucke, Frank, Niehoff, Anja
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Aged Aged, 80 and over Arthritis Biomedical materials Calcium Calcium ions Cartilage Cartilage (articular) Cartilage diseases Cartilage oligomeric matrix protein Cartilage Oligomeric Matrix Protein - metabolism Cartilage, Articular - metabolism Cell adhesion & migration Chondrocytes - metabolism Cytoskeleton Degeneration Disease Extracellular matrix Female Glycoproteins Homeostasis Humans Immunoblotting Knee Knee Joint - metabolism Knee Joint - pathology Localization Male Matrix protein Mechanotransduction Membrane Glycoproteins - metabolism Metabolism Microfilament Proteins - metabolism Middle Aged Mutation Osteoarthritis Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Osteoporosis Protein Transport Proteins Signal transduction Staining STIM1 protein Stromal Interaction Molecule 1 - metabolism Thrombospondin Thrombospondins - metabolism
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