Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction

Medically important flaviviruses cause diverse disease pathologies and collectively are responsible for a major global disease burden. A contributing factor to pathogenesis is secreted flavivirus nonstructural protein 1 (NS1). Despite demonstrated protection by NS1-specific antibodies against lethal...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-01, Vol.371 (6525), p.194-200
Hauptverfasser:	Biering, Scott B, Akey, David L, Wong, Marcus P, Brown, W Clay, Lo, Nicholas T N, Puerta-Guardo, Henry, Tramontini Gomes de Sousa, Francielle, Wang, Chunling, Konwerski, Jamie R, Espinosa, Diego A, Bockhaus, Nicholas J, Glasner, Dustin R, Li, Jeffrey, Blanc, Sophie F, Juan, Evan Y, Elledge, Stephen J, Mina, Michael J, Beatty, P Robert, Smith, Janet L, Harris, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - immunology Cross Reactions Crystal structure Crystallography, X-Ray Dengue - prevention & control Dengue - therapy Dengue fever Dengue Virus - immunology Domains Endothelium - immunology Epithelial cells Flaviviridae Glycocalyx - immunology Humans Infections Mice Monoclonal antibodies NS1 protein Pathogenesis Protective structures Protein Conformation, beta-Strand Protein Domains Proteins Public health RNA viruses Vaccine development Vaccines Vector-borne diseases Viral envelope proteins Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - immunology Viremia Viruses West Nile Fever - prevention & control West Nile Fever - therapy West Nile virus West Nile virus - immunology Zika virus Zika Virus - immunology Zika Virus Infection - prevention & control Zika Virus Infection - therapy
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