The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease
Hashimoto's disease is listed among the most common endocrine causes of obesity. As treatment of obesity in women with Hashimoto's disease is frequently unsuccessful, the aim of this study was to evaluate the effectiveness of two different reducing diets and their influence on changes in t...
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| Veröffentlicht in: | Nutrients 2021-03, Vol.13 (3), p.862 |
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| description | Hashimoto's disease is listed among the most common endocrine causes of obesity. As treatment of obesity in women with Hashimoto's disease is frequently unsuccessful, the aim of this study was to evaluate the effectiveness of two different reducing diets and their influence on changes in thyroid parameters in female patients. A six-month observational/interventional study was performed on 100 women aged 18-65 years, previously diagnosed with Hashimoto's disease and obesity and receiving L-thyroxine. The women were randomly assigned to the test group (group A,
= 50) following elimination/reducing diets, and the control group (group B,
= 50) following reducing diets with the same caloric content (without elimination). Anthropometric and thyroid parameters were evaluated at the beginning, after 3 months and after 6 months of treatment. In both groups a significant decrease in BMI and body fat percentage was achieved, but in test group A the decrease in BMI and body fat percentage was significantly greater than in control group B (
< 0.002 and
= 0.026, respectively). Serum TSH (thyroid stimulating hormon) levels decreased significantly more in group A than in group B (
< 0.001). Group A exhibited significantly greater increases in fT4 and fT3 levels than the control group (
< 0.001) as well as significantly greater decreases in the levels anti-TPO (thyroid peroxidase) (
< 0.001) and anti-TG (thyreoglobulin) antibodies (
= 0.048). The application of reducing diets with product elimination was found to be a more beneficial tool for changing anthropometric and thyroid parameters in women suffering from obesity and Hashimoto's disease than classic reducing diets with the same energy values and macronutrient content. |
| doi_str_mv | 10.3390/nu13030862 |
| format | Article |
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= 50) following elimination/reducing diets, and the control group (group B,
= 50) following reducing diets with the same caloric content (without elimination). Anthropometric and thyroid parameters were evaluated at the beginning, after 3 months and after 6 months of treatment. In both groups a significant decrease in BMI and body fat percentage was achieved, but in test group A the decrease in BMI and body fat percentage was significantly greater than in control group B (
< 0.002 and
= 0.026, respectively). Serum TSH (thyroid stimulating hormon) levels decreased significantly more in group A than in group B (
< 0.001). Group A exhibited significantly greater increases in fT4 and fT3 levels than the control group (
< 0.001) as well as significantly greater decreases in the levels anti-TPO (thyroid peroxidase) (
< 0.001) and anti-TG (thyreoglobulin) antibodies (
= 0.048). The application of reducing diets with product elimination was found to be a more beneficial tool for changing anthropometric and thyroid parameters in women suffering from obesity and Hashimoto's disease than classic reducing diets with the same energy values and macronutrient content.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13030862</identifier><identifier>PMID: 33808030</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipose Tissue ; Adolescent ; Adult ; Aged ; Anthropometry ; Antibodies ; Autoantibodies - blood ; Autoantigens - immunology ; Body composition ; Body fat ; Body Mass Index ; Diet ; Diet, Reducing - methods ; Dietitians ; Disease ; Energy value ; Female ; Food ; Hashimoto Disease - blood ; Hashimoto Disease - diet therapy ; Hashimoto Disease - immunology ; Humans ; Hypothyroidism ; Inflammation ; Iodide peroxidase ; Iodide Peroxidase - immunology ; Iron-Binding Proteins - immunology ; Medical laboratories ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - diet therapy ; Obesity - immunology ; Overweight ; Peroxidase ; Thyroglobulin - immunology ; Thyroid ; Thyroid Function Tests ; Thyroid gland ; Thyroid Gland - immunology ; Thyroid-stimulating hormone ; Thyrotropin - blood ; Thyroxine ; Thyroxine - therapeutic use ; Treatment Outcome ; Variables ; Womens health ; Young Adult</subject><ispartof>Nutrients, 2021-03, Vol.13 (3), p.862</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-ecded8536efd7931f17860869fbeebbb0408a6cb7cb1aca82f1b0929f40a47553</citedby><cites>FETCH-LOGICAL-c406t-ecded8536efd7931f17860869fbeebbb0408a6cb7cb1aca82f1b0929f40a47553</cites><orcidid>0000-0002-9821-9347 ; 0000-0002-0543-1817</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000220/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000220/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33808030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ostrowska, Lucyna</creatorcontrib><creatorcontrib>Gier, Dominika</creatorcontrib><creatorcontrib>Zyśk, Beata</creatorcontrib><title>The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Hashimoto's disease is listed among the most common endocrine causes of obesity. As treatment of obesity in women with Hashimoto's disease is frequently unsuccessful, the aim of this study was to evaluate the effectiveness of two different reducing diets and their influence on changes in thyroid parameters in female patients. A six-month observational/interventional study was performed on 100 women aged 18-65 years, previously diagnosed with Hashimoto's disease and obesity and receiving L-thyroxine. The women were randomly assigned to the test group (group A,
= 50) following elimination/reducing diets, and the control group (group B,
= 50) following reducing diets with the same caloric content (without elimination). Anthropometric and thyroid parameters were evaluated at the beginning, after 3 months and after 6 months of treatment. In both groups a significant decrease in BMI and body fat percentage was achieved, but in test group A the decrease in BMI and body fat percentage was significantly greater than in control group B (
< 0.002 and
= 0.026, respectively). Serum TSH (thyroid stimulating hormon) levels decreased significantly more in group A than in group B (
< 0.001). Group A exhibited significantly greater increases in fT4 and fT3 levels than the control group (
< 0.001) as well as significantly greater decreases in the levels anti-TPO (thyroid peroxidase) (
< 0.001) and anti-TG (thyreoglobulin) antibodies (
= 0.048). The application of reducing diets with product elimination was found to be a more beneficial tool for changing anthropometric and thyroid parameters in women suffering from obesity and Hashimoto's disease than classic reducing diets with the same energy values and macronutrient content.</description><subject>Adipose Tissue</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anthropometry</subject><subject>Antibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoantigens - immunology</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Diet</subject><subject>Diet, Reducing - methods</subject><subject>Dietitians</subject><subject>Disease</subject><subject>Energy value</subject><subject>Female</subject><subject>Food</subject><subject>Hashimoto Disease - blood</subject><subject>Hashimoto Disease - diet therapy</subject><subject>Hashimoto Disease - immunology</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Inflammation</subject><subject>Iodide peroxidase</subject><subject>Iodide Peroxidase - immunology</subject><subject>Iron-Binding Proteins - immunology</subject><subject>Medical laboratories</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - diet therapy</subject><subject>Obesity - immunology</subject><subject>Overweight</subject><subject>Peroxidase</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroid</subject><subject>Thyroid Function Tests</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - immunology</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine</subject><subject>Thyroxine - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Variables</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkV9LHDEUxYO0qFhf-gEk4EOlsG3-zGQyL4JsbRUES7uljyHJ3OxEZhJNZor77Zut1mrzknDzu4dz70HoLSUfOG_JxzBTTjiRgu2gfUYathCi4q-evffQYc43ZHsa0gi-i_Y4l0SWrn10v-oBXwY3zBAs4OjwN-hm68Maf_IwZRwDXvY6rCFjH_Cq36ToO_xVJz3CBOlP9WccIeDvs3OQtp0uxRFfG8h-2mAdOnyhc-_HOMV3uchm0BneoNdODxkOH-8D9OPz-Wp5sbi6_nK5PLta2IqIaQG2g07WXIDrmpZTRxspyrStMwDGGFIRqYU1jTVUWy2Zo4a0rHUV0VVT1_wAnT7o3s5mhM5CmJIe1G3yo04bFbVXL3-C79U6_lKy7IsxUgROHgVSvJshT2r02cIw6ABxzorVRNYtEa0s6PF_6E2cUyjjFUowWgtatYV6_0DZFHNO4J7MUKK2map_mRb46Ln9J_Rvgvw33kWdWw</recordid><startdate>20210305</startdate><enddate>20210305</enddate><creator>Ostrowska, Lucyna</creator><creator>Gier, Dominika</creator><creator>Zyśk, Beata</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9821-9347</orcidid><orcidid>https://orcid.org/0000-0002-0543-1817</orcidid></search><sort><creationdate>20210305</creationdate><title>The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease</title><author>Ostrowska, Lucyna ; Gier, Dominika ; Zyśk, Beata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-ecded8536efd7931f17860869fbeebbb0408a6cb7cb1aca82f1b0929f40a47553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose Tissue</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anthropometry</topic><topic>Antibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoantigens - immunology</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Diet</topic><topic>Diet, Reducing - methods</topic><topic>Dietitians</topic><topic>Disease</topic><topic>Energy value</topic><topic>Female</topic><topic>Food</topic><topic>Hashimoto Disease - blood</topic><topic>Hashimoto Disease - diet therapy</topic><topic>Hashimoto Disease - immunology</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Inflammation</topic><topic>Iodide peroxidase</topic><topic>Iodide Peroxidase - immunology</topic><topic>Iron-Binding Proteins - immunology</topic><topic>Medical laboratories</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - diet therapy</topic><topic>Obesity - immunology</topic><topic>Overweight</topic><topic>Peroxidase</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroid</topic><topic>Thyroid Function Tests</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - immunology</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine</topic><topic>Thyroxine - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Variables</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ostrowska, Lucyna</creatorcontrib><creatorcontrib>Gier, Dominika</creatorcontrib><creatorcontrib>Zyśk, Beata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ostrowska, Lucyna</au><au>Gier, Dominika</au><au>Zyśk, Beata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2021-03-05</date><risdate>2021</risdate><volume>13</volume><issue>3</issue><spage>862</spage><pages>862-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Hashimoto's disease is listed among the most common endocrine causes of obesity. As treatment of obesity in women with Hashimoto's disease is frequently unsuccessful, the aim of this study was to evaluate the effectiveness of two different reducing diets and their influence on changes in thyroid parameters in female patients. A six-month observational/interventional study was performed on 100 women aged 18-65 years, previously diagnosed with Hashimoto's disease and obesity and receiving L-thyroxine. The women were randomly assigned to the test group (group A,
= 50) following elimination/reducing diets, and the control group (group B,
= 50) following reducing diets with the same caloric content (without elimination). Anthropometric and thyroid parameters were evaluated at the beginning, after 3 months and after 6 months of treatment. In both groups a significant decrease in BMI and body fat percentage was achieved, but in test group A the decrease in BMI and body fat percentage was significantly greater than in control group B (
< 0.002 and
= 0.026, respectively). Serum TSH (thyroid stimulating hormon) levels decreased significantly more in group A than in group B (
< 0.001). Group A exhibited significantly greater increases in fT4 and fT3 levels than the control group (
< 0.001) as well as significantly greater decreases in the levels anti-TPO (thyroid peroxidase) (
< 0.001) and anti-TG (thyreoglobulin) antibodies (
= 0.048). The application of reducing diets with product elimination was found to be a more beneficial tool for changing anthropometric and thyroid parameters in women suffering from obesity and Hashimoto's disease than classic reducing diets with the same energy values and macronutrient content.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33808030</pmid><doi>10.3390/nu13030862</doi><orcidid>https://orcid.org/0000-0002-9821-9347</orcidid><orcidid>https://orcid.org/0000-0002-0543-1817</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adipose Tissue Adolescent Adult Aged Anthropometry Antibodies Autoantibodies - blood Autoantigens - immunology Body composition Body fat Body Mass Index Diet Diet, Reducing - methods Dietitians Disease Energy value Female Food Hashimoto Disease - blood Hashimoto Disease - diet therapy Hashimoto Disease - immunology Humans Hypothyroidism Inflammation Iodide peroxidase Iodide Peroxidase - immunology Iron-Binding Proteins - immunology Medical laboratories Middle Aged Obesity Obesity - blood Obesity - diet therapy Obesity - immunology Overweight Peroxidase Thyroglobulin - immunology Thyroid Thyroid Function Tests Thyroid gland Thyroid Gland - immunology Thyroid-stimulating hormone Thyrotropin - blood Thyroxine Thyroxine - therapeutic use Treatment Outcome Variables Womens health Young Adult |
| title | The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease |
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