Patient-Specific Modelling of Blood Coagulation
Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and...
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| Veröffentlicht in: | Bulletin of mathematical biology 2021-03, Vol.83 (5), p.50-50, Article 50 |
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| container_title | Bulletin of mathematical biology |
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| creator | Ratto, N. Bouchnita, A. Chelle, P. Marion, M. Panteleev, M. Nechipurenko, D. Tardy-Poncet, B. Volpert, V. |
| description | Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. Next, this model is used to study spatial distributions of blood factors and blood coagulation in flow, and to evaluate the results of medical treatment of blood coagulation disorders. |
| doi_str_mv | 10.1007/s11538-021-00890-8 |
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However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. 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However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. 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| ispartof | Bulletin of mathematical biology, 2021-03, Vol.83 (5), p.50-50, Article 50 |
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| subjects | Analysis of PDEs Biomedical materials Blood Coagulation Blood Coagulation Disorders - diagnosis Blood Coagulation Disorders - pathology Cell Biology Humans Life Sciences Mathematical and Computational Biology Mathematical models Mathematics Mathematics and Statistics Medical treatment Modelling Models, Biological Original Original Article Parameters Patient-Specific Modeling Patients Physiological effects Spatial distribution Thrombin |
| title | Patient-Specific Modelling of Blood Coagulation |
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