Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis
The bacterium Staphylococcus aureus , which colonizes healthy human skin, may cause diseases, such as atopic dermatitis (AD). Treatment for such AD cases involves antibiotic use; however, alternate treatments are preferred owing to the development of antimicrobial resistance. This study aimed to cha...
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| Veröffentlicht in: | Current microbiology 2021-04, Vol.78 (4), p.1267-1276 |
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| creator | Shimamori, Yuzuki Pramono, Ajeng K. Kitao, Tomoe Suzuki, Tohru Aizawa, Shin-ichi Kubori, Tomoko Nagai, Hiroki Takeda, Shigeki Ando, Hiroki |
| description | The bacterium
Staphylococcus aureus
, which colonizes healthy human skin, may cause diseases, such as atopic dermatitis (AD). Treatment for such AD cases involves antibiotic use; however, alternate treatments are preferred owing to the development of antimicrobial resistance. This study aimed to characterize the novel bacteriophage SaGU1 as a potential agent for phage therapy to treat
S. aureus
infections. SaGU1 that infects
S. aureus
strains previously isolated from the skin of patients with AD was screened from sewage samples in Gifu, Japan. Its genome was sequenced and analyzed using bioinformatics tools, and the morphology, lytic activity, stability, and host range of the phage were determined. The SaGU1 genome was 140,909 bp with an average GC content of 30.2%. The viral chromosome contained 225 putative protein-coding genes and four tRNA genes, carrying neither toxic nor antibiotic resistance genes. Electron microscopy analysis revealed that SaGU1 belongs to the
Myoviridae
family. Stability tests showed that SaGU1 was heat-stable under physiological and acidic conditions. Host range testing revealed that SaGU1 can infect a broad range of
S. aureus
clinical isolates present on the skin of AD patients, whereas it did not kill strains of
Staphylococcus epidermidis
, which are symbiotic resident bacteria on human skin. Hence, our data suggest that SaGU1 is a potential candidate for developing a phage therapy to treat AD caused by pathogenic
S. aureus
. |
| doi_str_mv | 10.1007/s00284-021-02395-y |
| format | Article |
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Staphylococcus aureus
, which colonizes healthy human skin, may cause diseases, such as atopic dermatitis (AD). Treatment for such AD cases involves antibiotic use; however, alternate treatments are preferred owing to the development of antimicrobial resistance. This study aimed to characterize the novel bacteriophage SaGU1 as a potential agent for phage therapy to treat
S. aureus
infections. SaGU1 that infects
S. aureus
strains previously isolated from the skin of patients with AD was screened from sewage samples in Gifu, Japan. Its genome was sequenced and analyzed using bioinformatics tools, and the morphology, lytic activity, stability, and host range of the phage were determined. The SaGU1 genome was 140,909 bp with an average GC content of 30.2%. The viral chromosome contained 225 putative protein-coding genes and four tRNA genes, carrying neither toxic nor antibiotic resistance genes. Electron microscopy analysis revealed that SaGU1 belongs to the
Myoviridae
family. Stability tests showed that SaGU1 was heat-stable under physiological and acidic conditions. Host range testing revealed that SaGU1 can infect a broad range of
S. aureus
clinical isolates present on the skin of AD patients, whereas it did not kill strains of
Staphylococcus epidermidis
, which are symbiotic resident bacteria on human skin. Hence, our data suggest that SaGU1 is a potential candidate for developing a phage therapy to treat AD caused by pathogenic
S. aureus
.</description><identifier>ISSN: 0343-8651</identifier><identifier>EISSN: 1432-0991</identifier><identifier>DOI: 10.1007/s00284-021-02395-y</identifier><identifier>PMID: 33638001</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antibiotic resistance ; Antibiotics ; Antimicrobial resistance ; Atopic dermatitis ; Bacteria ; Bioinformatics ; Biomedical and Life Sciences ; Biotechnology ; Chromosomes ; Clinical isolates ; Dermatitis ; Dermatitis, Atopic ; Eczema ; Electron microscopy ; Genes ; Genome, Viral ; Genomes ; Host range ; Humans ; Japan ; Life Sciences ; Microbiology ; Morphology ; Patients ; Phages ; Sewage ; Skin diseases ; Stability analysis ; Stability tests ; Staphylococcus aureus ; Staphylococcus aureus - genetics ; Staphylococcus Phages - genetics ; Strains (organisms) ; Thermal stability ; tRNA</subject><ispartof>Current microbiology, 2021-04, Vol.78 (4), p.1267-1276</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-675192d0cc2148032fae476f0afc71ae9847ef703d9006534fdf7bb5bd1275883</citedby><cites>FETCH-LOGICAL-c474t-675192d0cc2148032fae476f0afc71ae9847ef703d9006534fdf7bb5bd1275883</cites><orcidid>0000-0002-1660-7849</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00284-021-02395-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00284-021-02395-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33638001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimamori, Yuzuki</creatorcontrib><creatorcontrib>Pramono, Ajeng K.</creatorcontrib><creatorcontrib>Kitao, Tomoe</creatorcontrib><creatorcontrib>Suzuki, Tohru</creatorcontrib><creatorcontrib>Aizawa, Shin-ichi</creatorcontrib><creatorcontrib>Kubori, Tomoko</creatorcontrib><creatorcontrib>Nagai, Hiroki</creatorcontrib><creatorcontrib>Takeda, Shigeki</creatorcontrib><creatorcontrib>Ando, Hiroki</creatorcontrib><title>Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis</title><title>Current microbiology</title><addtitle>Curr Microbiol</addtitle><addtitle>Curr Microbiol</addtitle><description>The bacterium
Staphylococcus aureus
, which colonizes healthy human skin, may cause diseases, such as atopic dermatitis (AD). Treatment for such AD cases involves antibiotic use; however, alternate treatments are preferred owing to the development of antimicrobial resistance. This study aimed to characterize the novel bacteriophage SaGU1 as a potential agent for phage therapy to treat
S. aureus
infections. SaGU1 that infects
S. aureus
strains previously isolated from the skin of patients with AD was screened from sewage samples in Gifu, Japan. Its genome was sequenced and analyzed using bioinformatics tools, and the morphology, lytic activity, stability, and host range of the phage were determined. The SaGU1 genome was 140,909 bp with an average GC content of 30.2%. The viral chromosome contained 225 putative protein-coding genes and four tRNA genes, carrying neither toxic nor antibiotic resistance genes. Electron microscopy analysis revealed that SaGU1 belongs to the
Myoviridae
family. Stability tests showed that SaGU1 was heat-stable under physiological and acidic conditions. Host range testing revealed that SaGU1 can infect a broad range of
S. aureus
clinical isolates present on the skin of AD patients, whereas it did not kill strains of
Staphylococcus epidermidis
, which are symbiotic resident bacteria on human skin. Hence, our data suggest that SaGU1 is a potential candidate for developing a phage therapy to treat AD caused by pathogenic
S. aureus
.</description><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial resistance</subject><subject>Atopic dermatitis</subject><subject>Bacteria</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Chromosomes</subject><subject>Clinical isolates</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic</subject><subject>Eczema</subject><subject>Electron microscopy</subject><subject>Genes</subject><subject>Genome, Viral</subject><subject>Genomes</subject><subject>Host range</subject><subject>Humans</subject><subject>Japan</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Morphology</subject><subject>Patients</subject><subject>Phages</subject><subject>Sewage</subject><subject>Skin diseases</subject><subject>Stability analysis</subject><subject>Stability tests</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - 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Staphylococcus aureus
, which colonizes healthy human skin, may cause diseases, such as atopic dermatitis (AD). Treatment for such AD cases involves antibiotic use; however, alternate treatments are preferred owing to the development of antimicrobial resistance. This study aimed to characterize the novel bacteriophage SaGU1 as a potential agent for phage therapy to treat
S. aureus
infections. SaGU1 that infects
S. aureus
strains previously isolated from the skin of patients with AD was screened from sewage samples in Gifu, Japan. Its genome was sequenced and analyzed using bioinformatics tools, and the morphology, lytic activity, stability, and host range of the phage were determined. The SaGU1 genome was 140,909 bp with an average GC content of 30.2%. The viral chromosome contained 225 putative protein-coding genes and four tRNA genes, carrying neither toxic nor antibiotic resistance genes. Electron microscopy analysis revealed that SaGU1 belongs to the
Myoviridae
family. Stability tests showed that SaGU1 was heat-stable under physiological and acidic conditions. Host range testing revealed that SaGU1 can infect a broad range of
S. aureus
clinical isolates present on the skin of AD patients, whereas it did not kill strains of
Staphylococcus epidermidis
, which are symbiotic resident bacteria on human skin. Hence, our data suggest that SaGU1 is a potential candidate for developing a phage therapy to treat AD caused by pathogenic
S. aureus
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33638001</pmid><doi>10.1007/s00284-021-02395-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1660-7849</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Current microbiology, 2021-04, Vol.78 (4), p.1267-1276 |
| issn | 0343-8651 1432-0991 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antibiotic resistance Antibiotics Antimicrobial resistance Atopic dermatitis Bacteria Bioinformatics Biomedical and Life Sciences Biotechnology Chromosomes Clinical isolates Dermatitis Dermatitis, Atopic Eczema Electron microscopy Genes Genome, Viral Genomes Host range Humans Japan Life Sciences Microbiology Morphology Patients Phages Sewage Skin diseases Stability analysis Stability tests Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus Phages - genetics Strains (organisms) Thermal stability tRNA |
| title | Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis |
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