Effect of Musk Tongxin Dropping Pill on Myocardial Remodeling and Microcirculation Dysfunction in Diabetic Cardiomyopathy
Objective. To explore the effect of Musk Tongxin Dropping Pill (MTDP) on myocardial remodeling and microcirculation dysfunction in diabetic cardiomyopathy (DCM). Methods. Forty male SD rats were randomly divided into control group (control group, n = 10), DCM model group (DCM group, n = 10), DCM mod...
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| creator | Zhao, Jingjing Zhou, Yan Liu, Huahua Zheng, Zhaohai Liu, Shuqing Peng, Jiahao Guo, Hangyuan Tang, Weiliang Peng, Fang |
| description | Objective. To explore the effect of Musk Tongxin Dropping Pill (MTDP) on myocardial remodeling and microcirculation dysfunction in diabetic cardiomyopathy (DCM). Methods. Forty male SD rats were randomly divided into control group (control group, n = 10), DCM model group (DCM group, n = 10), DCM model + pioglitazone group (DCM + PLZ group, n = 10), and DCM model + MTDP group (DCM + MTDP group, n = 10). An intraperitoneal single injection of 65 mg/kg streptozotocin (STZ) was used to establish rat model of DCM and the rats in control group were treated with the same dose of sodium citrate buffer solution. DCM + PLZ group was treated with 3 mg/kg/d PLZ by ig after modeling, DCM + MTDP group was treated with 22 mg/kg/d MTDP by ig, and DCM group was treated with 2 ml/kg/d sodium carboxymethyl cellulose (CMC-Na) by ig. The general condition of rats was continuously observed. After intervening for 3 weeks, the random blood glucose of rats was detected by tail vein, and the echocardiography examination was performed. Blood specimens were collected from the abdominal aorta, serum nitric oxide (NO) and endothelin-1 (ET-1) were detected to estimate endothelial function, and tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1β, malondialdehyde (MDA), and superoxide dismutase (SOD) were detected to observe the changes of inflammation and oxidative stress indexes. The heart mass index (HMI) was calculated through the ratio of heart mass (HM) to the corresponding body mass (BM). Myocardial pathological tissue staining was performed. Results. Compared with control group, blood glucose in other three groups was higher. Left ventricular end systolic diameter (LVSD) and left ventricular end diastolic diameter (LVDD) in DCM group showed a significant increase, while left ventricular ejection fraction (LVEF) and heart rate (HR) in this group displayed an obvious decrease P |
| doi_str_mv | 10.1155/2021/6620564 |
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To explore the effect of Musk Tongxin Dropping Pill (MTDP) on myocardial remodeling and microcirculation dysfunction in diabetic cardiomyopathy (DCM). Methods. Forty male SD rats were randomly divided into control group (control group, n = 10), DCM model group (DCM group, n = 10), DCM model + pioglitazone group (DCM + PLZ group, n = 10), and DCM model + MTDP group (DCM + MTDP group, n = 10). An intraperitoneal single injection of 65 mg/kg streptozotocin (STZ) was used to establish rat model of DCM and the rats in control group were treated with the same dose of sodium citrate buffer solution. DCM + PLZ group was treated with 3 mg/kg/d PLZ by ig after modeling, DCM + MTDP group was treated with 22 mg/kg/d MTDP by ig, and DCM group was treated with 2 ml/kg/d sodium carboxymethyl cellulose (CMC-Na) by ig. The general condition of rats was continuously observed. After intervening for 3 weeks, the random blood glucose of rats was detected by tail vein, and the echocardiography examination was performed. Blood specimens were collected from the abdominal aorta, serum nitric oxide (NO) and endothelin-1 (ET-1) were detected to estimate endothelial function, and tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1β, malondialdehyde (MDA), and superoxide dismutase (SOD) were detected to observe the changes of inflammation and oxidative stress indexes. The heart mass index (HMI) was calculated through the ratio of heart mass (HM) to the corresponding body mass (BM). Myocardial pathological tissue staining was performed. Results. Compared with control group, blood glucose in other three groups was higher. Left ventricular end systolic diameter (LVSD) and left ventricular end diastolic diameter (LVDD) in DCM group showed a significant increase, while left ventricular ejection fraction (LVEF) and heart rate (HR) in this group displayed an obvious decrease P<0.01. BM and HM in DCM group exhibited a reduction, and HM/BM × 103 revealed an apparent increase P<0.01. The levels of serum NO and SOD were distinctly downregulated P<0.01, and the levels of ET-1, MDA, TNF-α, IL-1β, and IL-6 were remarkably upregulated P<0.01. Compared with DCM group, a significant decrease was observed in LVSD and LVDD in DCM + MTDP group, while LVEF and HR obviously increased P<0.05. BM and HM indicated an apparent increase, but HM/BM ×103 reduced distinctly P<0.01. The levels of serum NO and SOD were markedly upregulated P<0.05, and the levels of ET-1, MDA, TNF-α, IL-1β, and IL-6 were significantly downregulated P<0.05. HE staining showed that myocardial cells arranged neatly in the control group but not in the DCM group. The intercellular space between myocardial cells in DCM group increased, accompanied by damage of myocardial fibers and infiltration of inflammatory cells. Masson staining displayed an increase in interstitial collagen fibers in DCM group. Carstairs staining showed that microembolization occurred in the myocardium in DCM group, while in DCM + MTDP and DCM + PLZ groups the corresponding myocardial pathological changes were significantly improved. Conclusions. MTDP might show a positive effect on myocardial remodeling and microcirculation dysfunction in DCM rats.]]></description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/6620564</identifier><identifier>PMID: 33790977</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Aorta ; Blood ; Body mass ; Carboxymethylcellulose ; Cardiomyopathy ; Cardiovascular disease ; Cellulose ; Citric acid ; Collagen ; Diabetes ; Diabetes mellitus ; Drug dosages ; Echocardiography ; Ejection fraction ; Endothelin 1 ; Fibers ; Glucose ; Heart failure ; Heart rate ; Hospitals ; Immunoglobulins ; Inflammation ; Interleukin 6 ; Intervention ; Laboratory animals ; Malondialdehyde ; Metastases ; Myocardium ; Nitric oxide ; Oxidative stress ; Pioglitazone ; Solvents ; Superoxide dismutase ; Tumor necrosis factor-TNF ; Veins & arteries ; Ventricle</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021 (NA), p.6620564-10</ispartof><rights>Copyright © 2021 Jingjing Zhao et al.</rights><rights>Copyright © 2021 Jingjing Zhao et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Jingjing Zhao et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-8693b6c024ea434eb1e968a155f228c85dd3331b7ae3a5aa6c83615118ede2903</citedby><cites>FETCH-LOGICAL-c514t-8693b6c024ea434eb1e968a155f228c85dd3331b7ae3a5aa6c83615118ede2903</cites><orcidid>0000-0002-6809-5056 ; 0000-0002-3826-5632</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997770/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997770/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33790977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Xing, Guoqiang</contributor><creatorcontrib>Zhao, Jingjing</creatorcontrib><creatorcontrib>Zhou, Yan</creatorcontrib><creatorcontrib>Liu, Huahua</creatorcontrib><creatorcontrib>Zheng, Zhaohai</creatorcontrib><creatorcontrib>Liu, Shuqing</creatorcontrib><creatorcontrib>Peng, Jiahao</creatorcontrib><creatorcontrib>Guo, Hangyuan</creatorcontrib><creatorcontrib>Tang, Weiliang</creatorcontrib><creatorcontrib>Peng, Fang</creatorcontrib><title>Effect of Musk Tongxin Dropping Pill on Myocardial Remodeling and Microcirculation Dysfunction in Diabetic Cardiomyopathy</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description><![CDATA[Objective. To explore the effect of Musk Tongxin Dropping Pill (MTDP) on myocardial remodeling and microcirculation dysfunction in diabetic cardiomyopathy (DCM). Methods. Forty male SD rats were randomly divided into control group (control group, n = 10), DCM model group (DCM group, n = 10), DCM model + pioglitazone group (DCM + PLZ group, n = 10), and DCM model + MTDP group (DCM + MTDP group, n = 10). An intraperitoneal single injection of 65 mg/kg streptozotocin (STZ) was used to establish rat model of DCM and the rats in control group were treated with the same dose of sodium citrate buffer solution. DCM + PLZ group was treated with 3 mg/kg/d PLZ by ig after modeling, DCM + MTDP group was treated with 22 mg/kg/d MTDP by ig, and DCM group was treated with 2 ml/kg/d sodium carboxymethyl cellulose (CMC-Na) by ig. The general condition of rats was continuously observed. After intervening for 3 weeks, the random blood glucose of rats was detected by tail vein, and the echocardiography examination was performed. Blood specimens were collected from the abdominal aorta, serum nitric oxide (NO) and endothelin-1 (ET-1) were detected to estimate endothelial function, and tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1β, malondialdehyde (MDA), and superoxide dismutase (SOD) were detected to observe the changes of inflammation and oxidative stress indexes. The heart mass index (HMI) was calculated through the ratio of heart mass (HM) to the corresponding body mass (BM). Myocardial pathological tissue staining was performed. Results. Compared with control group, blood glucose in other three groups was higher. Left ventricular end systolic diameter (LVSD) and left ventricular end diastolic diameter (LVDD) in DCM group showed a significant increase, while left ventricular ejection fraction (LVEF) and heart rate (HR) in this group displayed an obvious decrease P<0.01. BM and HM in DCM group exhibited a reduction, and HM/BM × 103 revealed an apparent increase P<0.01. The levels of serum NO and SOD were distinctly downregulated P<0.01, and the levels of ET-1, MDA, TNF-α, IL-1β, and IL-6 were remarkably upregulated P<0.01. Compared with DCM group, a significant decrease was observed in LVSD and LVDD in DCM + MTDP group, while LVEF and HR obviously increased P<0.05. BM and HM indicated an apparent increase, but HM/BM ×103 reduced distinctly P<0.01. The levels of serum NO and SOD were markedly upregulated P<0.05, and the levels of ET-1, MDA, TNF-α, IL-1β, and IL-6 were significantly downregulated P<0.05. HE staining showed that myocardial cells arranged neatly in the control group but not in the DCM group. The intercellular space between myocardial cells in DCM group increased, accompanied by damage of myocardial fibers and infiltration of inflammatory cells. Masson staining displayed an increase in interstitial collagen fibers in DCM group. Carstairs staining showed that microembolization occurred in the myocardium in DCM group, while in DCM + MTDP and DCM + PLZ groups the corresponding myocardial pathological changes were significantly improved. Conclusions. MTDP might show a positive effect on myocardial remodeling and microcirculation dysfunction in DCM rats.]]></description><subject>Aorta</subject><subject>Blood</subject><subject>Body mass</subject><subject>Carboxymethylcellulose</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Cellulose</subject><subject>Citric acid</subject><subject>Collagen</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Drug dosages</subject><subject>Echocardiography</subject><subject>Ejection fraction</subject><subject>Endothelin 1</subject><subject>Fibers</subject><subject>Glucose</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Hospitals</subject><subject>Immunoglobulins</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Intervention</subject><subject>Laboratory animals</subject><subject>Malondialdehyde</subject><subject>Metastases</subject><subject>Myocardium</subject><subject>Nitric oxide</subject><subject>Oxidative stress</subject><subject>Pioglitazone</subject><subject>Solvents</subject><subject>Superoxide dismutase</subject><subject>Tumor necrosis factor-TNF</subject><subject>Veins & 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of Musk Tongxin Dropping Pill on Myocardial Remodeling and Microcirculation Dysfunction in Diabetic Cardiomyopathy</title><author>Zhao, Jingjing ; Zhou, Yan ; Liu, Huahua ; Zheng, Zhaohai ; Liu, Shuqing ; Peng, Jiahao ; Guo, Hangyuan ; Tang, Weiliang ; Peng, Fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-8693b6c024ea434eb1e968a155f228c85dd3331b7ae3a5aa6c83615118ede2903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aorta</topic><topic>Blood</topic><topic>Body mass</topic><topic>Carboxymethylcellulose</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Cellulose</topic><topic>Citric acid</topic><topic>Collagen</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Drug dosages</topic><topic>Echocardiography</topic><topic>Ejection fraction</topic><topic>Endothelin 1</topic><topic>Fibers</topic><topic>Glucose</topic><topic>Heart failure</topic><topic>Heart rate</topic><topic>Hospitals</topic><topic>Immunoglobulins</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Intervention</topic><topic>Laboratory animals</topic><topic>Malondialdehyde</topic><topic>Metastases</topic><topic>Myocardium</topic><topic>Nitric oxide</topic><topic>Oxidative stress</topic><topic>Pioglitazone</topic><topic>Solvents</topic><topic>Superoxide dismutase</topic><topic>Tumor necrosis factor-TNF</topic><topic>Veins & arteries</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jingjing</creatorcontrib><creatorcontrib>Zhou, Yan</creatorcontrib><creatorcontrib>Liu, Huahua</creatorcontrib><creatorcontrib>Zheng, Zhaohai</creatorcontrib><creatorcontrib>Liu, Shuqing</creatorcontrib><creatorcontrib>Peng, Jiahao</creatorcontrib><creatorcontrib>Guo, Hangyuan</creatorcontrib><creatorcontrib>Tang, 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Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jingjing</au><au>Zhou, Yan</au><au>Liu, Huahua</au><au>Zheng, Zhaohai</au><au>Liu, Shuqing</au><au>Peng, Jiahao</au><au>Guo, Hangyuan</au><au>Tang, Weiliang</au><au>Peng, Fang</au><au>Xing, Guoqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Musk Tongxin Dropping Pill on Myocardial Remodeling and Microcirculation Dysfunction in Diabetic Cardiomyopathy</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>NA</issue><spage>6620564</spage><epage>10</epage><pages>6620564-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract><![CDATA[Objective. To explore the effect of Musk Tongxin Dropping Pill (MTDP) on myocardial remodeling and microcirculation dysfunction in diabetic cardiomyopathy (DCM). Methods. Forty male SD rats were randomly divided into control group (control group, n = 10), DCM model group (DCM group, n = 10), DCM model + pioglitazone group (DCM + PLZ group, n = 10), and DCM model + MTDP group (DCM + MTDP group, n = 10). An intraperitoneal single injection of 65 mg/kg streptozotocin (STZ) was used to establish rat model of DCM and the rats in control group were treated with the same dose of sodium citrate buffer solution. DCM + PLZ group was treated with 3 mg/kg/d PLZ by ig after modeling, DCM + MTDP group was treated with 22 mg/kg/d MTDP by ig, and DCM group was treated with 2 ml/kg/d sodium carboxymethyl cellulose (CMC-Na) by ig. The general condition of rats was continuously observed. After intervening for 3 weeks, the random blood glucose of rats was detected by tail vein, and the echocardiography examination was performed. Blood specimens were collected from the abdominal aorta, serum nitric oxide (NO) and endothelin-1 (ET-1) were detected to estimate endothelial function, and tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1β, malondialdehyde (MDA), and superoxide dismutase (SOD) were detected to observe the changes of inflammation and oxidative stress indexes. The heart mass index (HMI) was calculated through the ratio of heart mass (HM) to the corresponding body mass (BM). Myocardial pathological tissue staining was performed. Results. Compared with control group, blood glucose in other three groups was higher. Left ventricular end systolic diameter (LVSD) and left ventricular end diastolic diameter (LVDD) in DCM group showed a significant increase, while left ventricular ejection fraction (LVEF) and heart rate (HR) in this group displayed an obvious decrease P<0.01. BM and HM in DCM group exhibited a reduction, and HM/BM × 103 revealed an apparent increase P<0.01. The levels of serum NO and SOD were distinctly downregulated P<0.01, and the levels of ET-1, MDA, TNF-α, IL-1β, and IL-6 were remarkably upregulated P<0.01. Compared with DCM group, a significant decrease was observed in LVSD and LVDD in DCM + MTDP group, while LVEF and HR obviously increased P<0.05. BM and HM indicated an apparent increase, but HM/BM ×103 reduced distinctly P<0.01. The levels of serum NO and SOD were markedly upregulated P<0.05, and the levels of ET-1, MDA, TNF-α, IL-1β, and IL-6 were significantly downregulated P<0.05. HE staining showed that myocardial cells arranged neatly in the control group but not in the DCM group. The intercellular space between myocardial cells in DCM group increased, accompanied by damage of myocardial fibers and infiltration of inflammatory cells. Masson staining displayed an increase in interstitial collagen fibers in DCM group. Carstairs staining showed that microembolization occurred in the myocardium in DCM group, while in DCM + MTDP and DCM + PLZ groups the corresponding myocardial pathological changes were significantly improved. Conclusions. MTDP might show a positive effect on myocardial remodeling and microcirculation dysfunction in DCM rats.]]></abstract><cop>United States</cop><pub>Hindawi</pub><pmid>33790977</pmid><doi>10.1155/2021/6620564</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6809-5056</orcidid><orcidid>https://orcid.org/0000-0002-3826-5632</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2021, Vol.2021 (NA), p.6620564-10 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7997770 |
| source | Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Aorta Blood Body mass Carboxymethylcellulose Cardiomyopathy Cardiovascular disease Cellulose Citric acid Collagen Diabetes Diabetes mellitus Drug dosages Echocardiography Ejection fraction Endothelin 1 Fibers Glucose Heart failure Heart rate Hospitals Immunoglobulins Inflammation Interleukin 6 Intervention Laboratory animals Malondialdehyde Metastases Myocardium Nitric oxide Oxidative stress Pioglitazone Solvents Superoxide dismutase Tumor necrosis factor-TNF Veins & arteries Ventricle |
| title | Effect of Musk Tongxin Dropping Pill on Myocardial Remodeling and Microcirculation Dysfunction in Diabetic Cardiomyopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A26%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Musk%20Tongxin%20Dropping%20Pill%20on%20Myocardial%20Remodeling%20and%20Microcirculation%20Dysfunction%20in%20Diabetic%20Cardiomyopathy&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Zhao,%20Jingjing&rft.date=2021&rft.volume=2021&rft.issue=NA&rft.spage=6620564&rft.epage=10&rft.pages=6620564-10&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2021/6620564&rft_dat=%3Cproquest_pubme%3E2546962525%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2506103340&rft_id=info:pmid/33790977&rfr_iscdi=true |